Larry Fang
Upjohn
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Publication
Featured researches published by Larry Fang.
Bioorganic & Medicinal Chemistry Letters | 2010
Roy K. Hom; Simeon Bowers; Jennifer Sealy; Anh P. Truong; Gary D. Probst; Martin L. Neitzel; R. Jeffrey Neitz; Larry Fang; Louis Brogley; Jing Wu; Andrei W. Konradi; Hing L. Sham; Gergely Toth; Hu Pan; Nanhua Yao; Dean R. Artis; Kevin P. Quinn; John-Michael Sauer; Kyle Powell; Zhao Ren; Frederique Bard; Ted Yednock; Irene Griswold-Prenner
From high throughput screening, we discovered compound 1, the prototype for a series of disubstituted thiophene inhibitors of JNK which is selective towards closely related MAP kinases p38 and Erk2. Herein we describe the evolution of these compounds to a novel class of thiophene and thiazole JNK inhibitors that retain favorable solubility, permeability, and P-gp properties for development as CNS agents for treatment of neurodegeneration. Compound 61 demonstrated JNK3 IC(50)=77 nM and retained the excellent broad kinase selectivity observed for the series.
Journal of Medicinal Chemistry | 2004
Roy K. Hom; Andrea Gailunas; Shumeye S. Mamo; Larry Fang; Jay S. Tung; Donald E. Walker; David P. Davis; Eugene D. Thorsett; Nancy Jewett; Joseph B. Moon; Varghese John
Journal of Medicinal Chemistry | 2003
Roy K. Hom; Larry Fang; Shumeye S. Mamo; Jay S. Tung; Ashley C. Guinn; Don Walker; David L. Davis; Andrea Gailunas; Eugene D. Thorsett; Sukanto Sinha; Jeroen Knops; Nancy Jewett; John P. Anderson; Varghese John
Archive | 2001
Roy K. Hom; Shumeye S. Mamo; Jay Tung; Andrea Gailunas; Varghese John; Larry Fang
Bioorganic & Medicinal Chemistry Letters | 2010
Anh P. Truong; Gary D. Probst; Jose Aquino; Larry Fang; Louis Brogley; Jennifer Sealy; Roy K. Hom; John A. Tucker; Varghese John; Jay S. Tung; Michael A. Pleiss; Andrei W. Konradi; Hing L. Sham; Michael S. Dappen; Gergley Tóth; Nanhua Yao; Eric Brecht; Hu Pan; Dean R. Artis; Lany Ruslim; Michael P. Bova; Sukanto Sinha; Ted Yednock; Wes Zmolek; Kevin P. Quinn; John-Michael Sauer
Archive | 2002
John Freskos; David L. Brown; Larry Fang; Yvette M. Fobian; John Varghese; Arthur Glenn Romero
Archive | 2005
Varghese John; Jennifer Sealy; Jose Aquino; Gary D. Probst; Jay Tung; Larry Fang; Barbara Jagodzinska
Archive | 2002
John Freskos; David L. Brown; Yvette M. Fobian; Larry Fang; Arthur Glenn Romero; Varghese John
Archive | 2002
John N. Freskos; David L. Brown; Larry Fang; Yvette M. Fobian; John Varghese; Arthur Glenn Romero
Archive | 2002
James P. Beck; Larry Fang; John N. Freskos; Andrea Gailunas; Barbara Jagodzinska; Varghese John; Michel Maillard; John Mickelson; Lakshman Samala; Jennifer Sealy; Ruth E. Tenbrink
Collaboration
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