Andrea Klock
University of Freiburg
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Zentralblatt Fur Chirurgie | 2009
Hannes P. Neeff; Frank Makowiec; J. Harder; V. Gumpp; Andrea Klock; Robert Thimme; Oliver Drognitz; Ulrich T. Hopt
BACKGROUND Hepatocellular carcinoma (HCC) is the fifth-leading cause of cancer death world-wide. Although less frequent in Western Europe, its incidence is increasing in this region. Causes involved in the pathogenesis of HCC are, besides viral hepatitis, metabolic and nutritional factors (alcohol, diabetes, obesity). The therapeutic management depends strongly on the initial extent of disease and includes hepatic resection, liver transplantation and local ablation. In this context, we present our results on liver resection for HCC and a discussion of the current literature about (potentially curative) treatment for HCC. PATIENTS From 1999 until 2008 93 patients [83 % male, median age 64 (range: 39-94) years] underwent hepatic resection for HCC. Postoperative follow-up was available in 85 patients [median follow-up: 1.2 (0.25-8) years]. RESULTS In contrast to data, especially from Asia, a viral hepatitis as the origin of HCC was found in only 28 % of the patients in our series. Half of the patients had proven liver cirrhosis. The median number of intrahepatic tumours was one (1-11), median size of the largest tumour was 55 mm (5-250 mm). 58 % of the HCC were removed by atypical or segmental resection, 42 % of the patients underwent hemihepatectomy or extended -hemihepatectomy. Tumor-free resection margins were -achieved in 95 %. Total postoperative morbidity was 61 %. A reoperation for complications was -necessary in 10 %. Hospital mortality was 8.6 % in the entire study period but decreased from 14.9 % in 1999-2004 to 2.2 % in 2005 to 2008 (p = 0.03). Actuarial survival was 81 % after 1 year, 58 % after 3 years and 26 % after 5 years. The T-stage could be identified tendentially as a prognostic factor influencing survival. CONCLUSION With the proper selection of patients, liver resection for HCC may be performed with a curative intention (i. e., free resection margins) in over 90 %. Although it decreased during the study period peri-operative mortality was higher than after resection of other hepatic tumours. Long-term survival in our series was comparable to reports from other European centres.
Digestive and Liver Disease | 2018
Frank Makowiec; Magdalena Menzel; Peter Bronsert; P Holzner; Andrea Klock; Sven A. Lang; Stefan Fichtner-Feigl; Hannes P. Neeff
INTRODUCTION In unresectable patients with metastatic colorectal cancer (CRC), the site of the primary is a strong prognostic factor warranting major adjustments in palliative medical treatment. Initial results suggested that the site of CRC influences prognosis after curative resection of colorectal liver metastases (CLM). In this study, we evaluated outcome after resection of isolated CLM with regard to the location of the primary. METHODS 221 patients with macroscopically complete resection of CLM and no known extrahepatic disease were identified. 63 patients had right-sided and 158 had left-sided CRC. Tumors of the transverse colon and rectum were excluded. Survival was evaluated using the Kaplan-Meier method. RESULTS Characteristics of CLM, primary tumor stage and chemotherapeutic regimens were not significantly different between the two groups. Kaplan-Meier five-year survival was comparable (41%) in patients with right- or left-sided CRC (p = 0.64). Microscopic resection margin, number of liver metastases, age and nodal status but not the site of the primary tumor significantly influenced survival. CONCLUSION The site of the colorectal primary in this well-defined group of patients after resection of isolated CLM did not prove to be of significant prognostic value. Whether the primary tumor in CLM is located on the left side or the right should not preclude patients from surgery.
International Journal of Colorectal Disease | 2012
Hannes P. Neeff; Oliver Drognitz; Andrea Klock; Gerald Illerhaus; Oliver G. Opitz; Ulrich T. Hopt; Frank Makowiec
International Journal of Colorectal Disease | 2013
Hannes P. Neeff; Oliver Drognitz; P Holzner; Andrea Klock; Peter Bronsert; Ulrich T. Hopt; Frank Makowiec
International Journal of Colorectal Disease | 2018
Frank Makowiec; Peter Bronsert; Andrea Klock; Ulrich T. Hopt; Hannes P. Neeff
Chirurg | 2018
Hannes P. Neeff; P Holzner; M. Menzel; Peter Bronsert; Andrea Klock; S. A. Lang; Stefan Fichtner-Feigl; Ulrich T. Hopt; Frank Makowiec
Gastroenterology | 2016
Hannes P. Neeff; P Holzner; Andrea Klock; Peter Bronsert; Ulrich T. Hopt; Frank Makowiec
Gastroenterology | 2013
Hannes P. Neeff; Oliver Drognitz; Andrea Klock; Peter Bronsert; Ulrich T. Hopt; Frank Makowiec
Gastroenterology | 2011
Frank Makowiec; Hannes P. Neeff; Andrea Klock; Oliver Drognitz; Ulrich T. Hopt
Gastroenterology | 2011
Frank Makowiec; Hannes P. Neeff; Oliver Drognitz; Andrea Klock; Ulrich T. Hopt