Andreas Nandy

Update of the WHO/IUIS Allergen Nomenclature Database based on analysis of allergen sequences

The IUIS Allergen Nomenclature Sub‐Committee, under the auspices of the World Health Organization and the International Union of Immunological Societies, maintains the systematic nomenclature of allergenic proteins and publishes a database of approved allergen names on its Web site, www.allergen.org. In this paper, we summarize updates of allergen names approved at the meetings of the committee in 2011 through 2013. These changes reflect recent progress in identification, cloning, and sequencing of allergens. The goals of this update were to increase consistency in the classification of allergens, isoallergens, and variants and in the incorporation of the evolutionary classification of proteins into allergen nomenclature, while keeping changes of established names to a minimum in the interest of continuity. Allergens for which names have been updated include respiratory allergens from birch and ragweed pollen, midge larvae, and horse dander; food allergens from peanut, cows milk, and tomato; and cereal grain allergens. The IUIS Allergen Nomenclature Sub‐Committee encourages researchers to use these updated allergen names in future publications.

Rapid method for arrayed investigation of IgE‐reactivity profiles using natural and recombinant allergens

Background: The availability of increasing numbers of purified natural and recombinant allergens offer the possibility for component‐resolved characterization of IgE binding. To make use of this potential, fast and simple methods with high capacity have to be developed.

Standardization of allergen products: 2. Detailed characterization of GMP‐produced recombinant Phl p 5.0109 as European Pharmacopoeia reference standard

The Biological Standardization Programme of the European Directorate for Quality of Medicines and Healthcare (EDQM) aims at the establishment of well‐characterized reference standards based on recombinant allergens and validated assays for the quantification of major allergen content. The objective of this study was to examine the detailed physicochemical and immunological characterization of recombinant Phl p 5.0109, the second available allergen reference standard.

Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.