Andreas Schenzle
DuPont
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Featured researches published by Andreas Schenzle.
Applied and Environmental Microbiology | 2005
Luan Tao; Andreas Schenzle; J. Martin Odom; Qiong Cheng
ABSTRACT Biosynthesis of C30 carotenoids is relatively restricted in nature but has been described in Staphylococcus and in methylotrophic bacteria. We report here identification of a novel gene (crtNb) involved in conversion of 4,4′-diapolycopene to 4,4′-diapolycopene aldehyde. An aldehyde dehydrogenase gene (ald) responsible for the subsequent oxidation of 4,4′-diapolycopene aldehyde to 4,4′-diapolycopene acid was also identified in Methylomonas. CrtNb has significant sequence homology with diapophytoene desaturases (CrtN). However, data from knockout of crtNb and expression of crtNb in Escherichia coli indicated that CrtNb is not a desaturase but rather a novel carotenoid oxidase catalyzing oxidation of the terminal methyl group(s) of 4,4′-diaponeurosporene and 4,4′-diapolycopene to the corresponding terminal aldehyde. It has moderate to low activity on neurosporene and lycopene and no activity on β-carotene or ζ-carotene. Using a combination of C30 carotenoid synthesis genes from Staphylococcus and Methylomonas, 4,4′-diapolycopene dialdehyde was produced in E. coli as the predominant carotenoid. This C30 dialdehyde is a dark-reddish purple pigment that may have potential uses in foods and cosmetics.
Applied and Environmental Microbiology | 1997
Andreas Schenzle; Hiltrud Lenke; Peter Fischer; P. A. Williams; H.-J. Knackmuss
Applied and Environmental Microbiology | 1999
Andreas Schenzle; Hiltrud Lenke; Jim C. Spain; Hans-Joachim Knackmuss
Archive | 2001
J. Martin Odom; Kelley Christine Norton; Andreas Schenzle; Rick W. Ye
Archive | 2002
Qiong Cheng; Mattheos Koffas; Kelley Christine Norton; James M. Odom; Stephen K. Picataggio; Andreas Schenzle; Jean-Francois Tomb; Pierre E. Rouviere
Journal of Bacteriology | 1999
Andreas Schenzle; Hiltrud Lenke; Jim C. Spain; Hans-Joachim Knackmuss
Archive | 2001
Mattheos Koffas; James M. Odom; Andreas Schenzle
Archive | 2001
Mattheos Koffas; James M. Odom; Andreas Schenzle
Archive | 2001
Mattheos Koffas; James M. Odom; Andreas Schenzle
Archive | 2001
Mattheos Koffas; James M. Odom; Andreas Schenzle