Andreas Wysluch

Intraoperative evaluation of bony margins with frozen-section analysis and trephine drill extraction technique: A preliminary study.

The aim of this study was to examine the use of trephine drill specimens from mandible bony margins subjected to standard histologic fresh‐frozen processing for intraoperative documentation of malignant bony infiltration in oral cancer.

Orbital complications due to an acute odontogenic focus in a child. A case report

The full clinical manifestations of complications due to odontogenic foci are rarely seen in daily dental practice and can take a clinically foudroyant course of development in young people owing to anatomic conditions, as demonstrated in this clinical case in a 12-year-old girl. Endodontic treatment of the first right upper molar was started owing to increasing toothache and swelling of fossa canina and the periorbital region. During the course of treatment, the patient exhibited an acute increase in orbital inflammation, which required immediate surgical intervention with postsurgical intravenous antibiotic administration. This case should serve to emphasize the crucial requirement for intensive attention to orbital symptoms after dental procedures.

Decreased cognitive functioning in patients with advanced oral squamous cell carcinoma

Cognitive impairment causes a delay in diagnosis and treatment of the various cancer entities, resulting in reduced surgical outcomes and patient survival. However, no investigations have been carried out as to whether an association exists between cognitive functioning and tumour size in patients with oral squamous cell carcinoma (OSCC). In this study, 46 patients with OSCC were evaluated by using a screening test for dementia, consisting of a combination of the mini-mental state examination and the clock test (81% sensitivity and 90% specificity). Test scores were correlated with tumour size according to the TNM staging system, which was categorized as being either limited (T1, T2; n=24) or advanced (T3, T4; n=22). No difference in age (P=0.172), sex (P=0.330), the percentage of drinkers (P=0.090) or the percentage of smokers (P=0.484) was evident between the groups. Patients with advanced tumour size scored significantly lower (median 5.5 of 9 possible points) when compared with those having tumours of a limited size (median 9 of 9 possible points; P=0.005). The median score of patients with T3/T4 tumours suggested the need for comprehensive neuropsychological evaluations for dementia. In conclusion, this study has demonstrated the correlation of reduced cognitive functioning in patients with advanced OSCC. As a consequence, instructions for the identification of early signs and of symptoms of oral cancer are strongly recommended for relatives and nursing staff of patients with cognitive impairment. Such patients might need immediate treatment for oral cancer but might not be able to understand the significance of their symptoms and therefore present late, often too late.

Giant ameloblastoma of the jaw

Ameloblastomas represent benign, epithelial alveolar tumors, which originate from epithelial enamel cells (ameloblasts). Due to their locally aggressive character, they may develop pathological significance. Radical surgery remains the therapy of choice. As demonstrated by the case of a 71-year-old patient with giant ameloblastoma of the upper jaw, early resection is recommended. The high propensity for recurrence demands long-term post-operative follow-up, since late recidive tumours may also occur.ZusammenfassungAmeloblastome stellen gutartige, epitheliale Kiefergeschwülste dar, die von schmelzbildenden, epithelialen Zellen (Ameloblasten) der Zahnanlage ausgehen. Aufgrund ihres lokal aggressiven Charakters können sie einen bedeutenden Krankheitswert annehmen. Die radikalchirurgische Behandlung ist bis dato die Therapie der Wahl. Die Kasuistik eines 71-jährigen Patienten mit monströsem Ameloblastom des Unterkiefers soll verdeutlichen, dass eine möglichst frühzeitige Entfernung anzuempfehlen ist. Aufgrund der Rezidivfreudigkeit sind mehrjährige Kontrollen anzuraten, da auch späte Rezidive auftreten können.AbstractAmeloblastomas represent benign, epithelial alveolar tumors, which originate from epithelial enamel cells (ameloblasts). Due to their locally aggressive character, they may develop pathological significance. Radical surgery remains the therapy of choice. As demonstrated by the case of a 71-year-old patient with giant ameloblastoma of the upper jaw, early resection is recommended. The high propensity for recurrence demands long-term post-operative follow-up, since late recidive tumours may also occur.

Die Leishmaniasis – eine parasitäre Erkrankung als Differenzialdiagnose maligner Mundschleimhauterkrankungen. Fallbericht und Literaturübersicht

Although parasitel infections in northern Europe are rare, it must be considered as differential diagnosis of malignant tumours of mucous membrane. With increasing tourisms in endemic areas, infections with parasite pathogen are spreading in non-endemic areas as well. In this case a mucous membrane malignancy with clinical feature of ulcer on unusual location was imitated. In this reported case the patient suffers with hepatitis c, causing cirrhosis of the liver and making a liver transplantation necessary. In this patient a history of a leishmaniosis which had been treated successful by the tropical institute is reported, but because of a new actually leishmaniosis-infection a liver transplantation is contraindicated. Under oral therapy with Miltefosin (IMPADIVO) a remission was successful. The leishmaniosis is a classical tropical disease. WHO reported a morbidity of nearly 12 million people in 88 countries around the world especially in tropical areas. Repeatedly infections in northern Europe caused by the phlebotonus-sandflies are described. Therefore leishmaniosis must be considered as differential diagnosis in suspect lesions of mucous membrane.

Monströses Ameloblastom des Unterkiefers

Ameloblastomas represent benign, epithelial alveolar tumors, which originate from epithelial enamel cells (ameloblasts). Due to their locally aggressive character, they may develop pathological significance. Radical surgery remains the therapy of choice. As demonstrated by the case of a 71-year-old patient with giant ameloblastoma of the upper jaw, early resection is recommended. The high propensity for recurrence demands long-term post-operative follow-up, since late recidive tumours may also occur.ZusammenfassungAmeloblastome stellen gutartige, epitheliale Kiefergeschwülste dar, die von schmelzbildenden, epithelialen Zellen (Ameloblasten) der Zahnanlage ausgehen. Aufgrund ihres lokal aggressiven Charakters können sie einen bedeutenden Krankheitswert annehmen. Die radikalchirurgische Behandlung ist bis dato die Therapie der Wahl. Die Kasuistik eines 71-jährigen Patienten mit monströsem Ameloblastom des Unterkiefers soll verdeutlichen, dass eine möglichst frühzeitige Entfernung anzuempfehlen ist. Aufgrund der Rezidivfreudigkeit sind mehrjährige Kontrollen anzuraten, da auch späte Rezidive auftreten können.AbstractAmeloblastomas represent benign, epithelial alveolar tumors, which originate from epithelial enamel cells (ameloblasts). Due to their locally aggressive character, they may develop pathological significance. Radical surgery remains the therapy of choice. As demonstrated by the case of a 71-year-old patient with giant ameloblastoma of the upper jaw, early resection is recommended. The high propensity for recurrence demands long-term post-operative follow-up, since late recidive tumours may also occur.

Monströses Ameloblastom des Unterkiefers@@@Giant ameloblastoma of the jaw

Ameloblastomas represent benign, epithelial alveolar tumors, which originate from epithelial enamel cells (ameloblasts). Due to their locally aggressive character, they may develop pathological significance. Radical surgery remains the therapy of choice. As demonstrated by the case of a 71-year-old patient with giant ameloblastoma of the upper jaw, early resection is recommended. The high propensity for recurrence demands long-term post-operative follow-up, since late recidive tumours may also occur.ZusammenfassungAmeloblastome stellen gutartige, epitheliale Kiefergeschwülste dar, die von schmelzbildenden, epithelialen Zellen (Ameloblasten) der Zahnanlage ausgehen. Aufgrund ihres lokal aggressiven Charakters können sie einen bedeutenden Krankheitswert annehmen. Die radikalchirurgische Behandlung ist bis dato die Therapie der Wahl. Die Kasuistik eines 71-jährigen Patienten mit monströsem Ameloblastom des Unterkiefers soll verdeutlichen, dass eine möglichst frühzeitige Entfernung anzuempfehlen ist. Aufgrund der Rezidivfreudigkeit sind mehrjährige Kontrollen anzuraten, da auch späte Rezidive auftreten können.AbstractAmeloblastomas represent benign, epithelial alveolar tumors, which originate from epithelial enamel cells (ameloblasts). Due to their locally aggressive character, they may develop pathological significance. Radical surgery remains the therapy of choice. As demonstrated by the case of a 71-year-old patient with giant ameloblastoma of the upper jaw, early resection is recommended. The high propensity for recurrence demands long-term post-operative follow-up, since late recidive tumours may also occur.