Andrew W. McCollough

Neural measures reveal individual differences in controlling access to working memory

The capacity of visual short-term memory is highly limited, maintaining only three to four objects simultaneously. This extreme limitation necessitates efficient mechanisms to select only the most relevant objects from the immediate environment to be represented in memory and to restrict irrelevant items from consuming capacity. Here we report a neurophysiological measure of this memory selection mechanism in humans that gauges an individuals efficiency at excluding irrelevant items from being stored in memory. By examining the moment-by-moment contents of visual memory, we observe that selection efficiency varies substantially across individuals and is strongly predicted by the particular memory capacity of each person. Specifically, high capacity individuals are much more efficient at representing only the relevant items than are low capacity individuals, who inefficiently encode and maintain information about the irrelevant items present in the display. These results provide evidence that under many circumstances low capacity individuals may actually store more information in memory than high capacity individuals. Indeed, this ancillary allocation of memory capacity to irrelevant objects may be a primary source of putative differences in overall storage capacity.

Electrophysiological Measures of Maintaining Representations in Visual Working Memory

Visual working memory (WM) is a limited capacity system which maintains information about objects in the immediate visual environment. Recent neurophysiological and neuroimaging studies have identified sustained memory-item specific activity during the retention period of WM tasks, and this activity may be a physiological substrate of maintaining representations in WM. In the present study, we present an electrophysiological measure of delay activity using event-related potentials (ERPs). Subjects were asked to remember the items in a single hemifield presented within a bilateral display. Approximately 200 msec following the onset of the memory array, we observed a large negative wave at electrode sites that were contralateral with respect to the position of the memory items. This activity persisted throughout the retention period and appears to be an analog to delay activity observed in monkey single-unit and functional magnetic resonance imaging (fMRI) WM studies. The contralateral delay activity is modulated by the number of items in the memory array but reaches asymptote for arrays of 3 to 4 items. This activity is similar across different classes of simple objects and the amplitude is smaller on incorrect response trials relative to correct trials, suggesting that this activity is necessary for correct performance on a given trial. Together, these results appear to indicate an electrophysiological index of the maintained representations in visual WM.

Contralateral Delay Activity Provides a Neural Measure of the Number of Representations in Visual Working Memory

Visual working memory (VWM) helps to temporarily represent information from the visual environment and is severely limited in capacity. Recent work has linked various forms of neural activity to the ongoing representations in VWM. One piece of evidence comes from human event-related potential studies, which find a sustained contralateral negativity during the retention period of VWM tasks. This contralateral delay activity (CDA) has previously been shown to increase in amplitude as the number of memory items increases, up to the individuals working memory capacity limit. However, significant alternative hypotheses remain regarding the true nature of this activity. Here we test whether the CDA is modulated by the perceptual requirements of the memory items as well as whether it is determined by the number of locations that are being attended within the display. Our results provide evidence against these two alternative accounts and instead strongly support the interpretation that this activity reflects the current number of objects that are being represented in VWM.

Attentional enhancement during multiple-object tracking

What is the role of attention in multiple-object tracking? Does attention enhance target representations, suppress distractor representations, or both? It is difficult to ask this question in a purely behavioral paradigm without altering the very attentional allocation one is trying to measure. In the present study, we used event-related potentials to examine the early visual evoked responses to task-irrelevant probes without requiring an additional detection task. Subjects tracked two targets among four moving distractors and four stationary distractors. Brief probes were flashed on targets, moving distractors, stationary distractors, or empty space. We obtained a significant enhancement of the visually evoked P1 and N1 components (∼100–150 msec) for probes on targets, relative to distractors. Furthermore, good trackers showed larger differences between target and distractor probes than did poor trackers. These results provide evidence of early attentional enhancement of tracked target items and also provide a novel approach to measuring attentional allocation during tracking.

Event-related potential measures of visual working memory.

Visual working memory is a limited capacity system that temporarily maintains information about objects in the immediate visual environment. Psychophysical experiments have shown that most people are able to actively maintain 3 or 4 items in visual working memory at any point in time To better understand how this process works and why our working memory capacity is so limited, a variety of neurophysiological approaches have been employed. In recent years, there has been a surge of interest in understanding how visual information is maintained in working memory at the neural level. Single-cell research with non-human primates has shown that neuronal firing during the retention period reflects the information that is currently held in working memory. In humans, event-related potentials (ERPs) have been used to examine the maintenance of information in working memory. An event-related potential component, known as the negative slow wave (NSW), has been used to measure the maintenance of information in working memory “online” during a given trial. More recently, another ERP component, the contralateral delay activity (CDA) has been shown to be a fairly specific correlate of the current contents of working memory. This component is sensitive to an individuals working memory capacity and may provide a window into the operations of this central cognitive construct.