Angelo G. Giumanini

Gas chromatographic analysis of aromatic amines as N-permethylated derivatives

A gas chromatographic method for the analysis of primary and secondary aromatic amines is described, based on their prior conversion into N-permethyl derivatives by treatment with formaldehyde and sodium borohydride in acidic solution. The usually difficult separation of isomers is thus easily achieved for toluidines, xylidines, anisidines and naphthylamines. Flame-ionization detector responses are enhanced and the absorption problems, which were found to be concentration dependent, are very limited.

Pyrolysis gas chromatography-mass spectrometry for the identification of anthocyanins

Abstract A new method is described for the rapid qualitative identification of anthocyanins which is based on recognition of differential features of the individual pyrograms and identification by gas-liquid chromatography coupled with mass spectrometric analysis.

Urinary Metabolites from (2-Ethyl-2,3-Dihydro-5-Benzofuranyl) Acetic Acid

The identification of urinary metabolites of 2-ethyl-2,3-dihydro-benzofuranyl acetic acid (1a) (prepared by Schiapparelli Research Laboratories (1, 2)) was undertaken as a consequence of discovery of its good antiinflammatory activity and low general systemic toxicity. The search for metabolites was preliminarily restricted to acidic compounds in the reasonable assumption that the acidic function originally present in 1a could not be destroyed. In fact from an acidified urine chloroform extract of treated rats four compounds related to Ia (Fig. 1) could be separated by tlc.