Anjan Ghatak

Strategic use of retro Diels-Alder reaction in the construction of β -carboxy-α-methylene-γ-lactones. Total synthesis of methylenolactocin and protolichesterinic acid

Abstract A facile route for the construction of β-carboxy-α-methylene-γ-lactone unit is described using retro Diels-Alder reaction as the key step. Using this protocol, total synthesis of (±)-methylenolactocin and (±)-protolichesterinic acid has been achieved.

Efficient generation and [3+2] cycloaddition of cyclic azomethine ylides : a general synthetic route to X-azabicyclo(m.2.1) alkane framework

An effecient method of cyclic azomethine ylide generation and their application in synthesizing x-azabicyclo (m.2.1) alkanes has been described.

Stereocontrolled total synthesis of (±)-β-necrodol

Abstract A total synthesis of racemic β-necrodol is described using an ortho-ester Claisen rearrangement as the key step to dictate a high level of trans-1,3-diastereoselection on a cyclopentane derivative.

High diastereoselectivity in Claisen rearrangement in a sterically congested cyclopentane system. Total synthesis of (±)-β-necrodol

Abstract Total synthesis of the monoterpene β-necrodol has been accomplished. The key step involves an ortho -ester Claisen rearrangement in a highly sterically congested cyclopentane derivative resulting in a high level of 1,3- trans diastereoselection. A novel photo-induced decarboxylation of the obtained γ,δ-unsaturated acid afforded β-necrodol.