Ann Bøcher Secher Banke

Incidence of cancer in patients with chronic heart failure: a long-term follow-up study

With improvement in survival of chronic heart failure (HF), the clinical importance of co‐morbidity is increasing. The aim of this study was to assess the incidence and risk of cancer and all‐cause mortality in a large Danish HF cohort.

Long-term effect of epirubicin on incidence of heart failure in women with breast cancer: insight from a randomized clinical trial: Long-term effect of epirubicin on heart failure

Anthracycline‐based chemotherapy improves survival in breast cancer patients but is associated with increased risk of heart failure (HF). However, the risk of late‐onset HF is debatable and mainly based on observational studies. The aim of this study was to evaluate the effect of anthracycline‐based chemotherapy on long‐term risk of clinical HF.

Hemodynamic Characteristics in Significant Symptomatic and Asymptomatic Primary Mitral Valve Regurgitation at Rest and During Exercise

Background— In severe asymptomatic primary mitral valve regurgitation without risk factors, surgery strategy is controversial. We sought to clarify whether being symptomatic corresponds to the hemodynamic burden and reduced exercise capacity. A better understanding of this may contribute to optimize timing of surgery. Methods and Results— Subjects with asymptomatic (New York Heart Association functional class I, n=29) or symptomatic (New York Heart Association functional class II and III, n=28) significant primary mitral valve regurgitation (effective regurgitant orifice, ≥0.30 cm2; left ventricular ejection fraction, >60%) were included. Right heart catheterization during rest and exercise, echocardiography, magnetic resonance imaging, and peak oxygen consumption test was performed. Symptomatic subjects had significantly higher pulmonary capillary wedge pressure at rest (14±4 versus 11±3 mm Hg; P=0.003) and at maximal exercise (30±6 versus 25±7 mm Hg; P=0.02) and higher mean pulmonary artery pressure (PAP) at rest (22±7 versus 18±4 mm Hg; P=0.005) and maximal exercise (46±8 versus 39±7 mm Hg; P=0.005) than asymptomatic subjects. Among asymptomatic subjects with normal resting value, exercise testing revealed a systolic PAP >60 mm Hg in 34%. Also the reverse response with minimal increase in pulmonary capillary wedge pressure and mean PAP during exercise was seen, especially in asymptomatic subjects. Among symptomatic subjects, we found a significant inverse correlation between resting mean PAP and left ventricular ejection fraction (r=−0.52; P=0.02) and right ventricular ejection fraction (r=−0.67; P<0.01). Peak oxygen consumption was equal and normal in both groups and correlated with left ventricular stroke volume but not with pulmonary capillary wedge pressure. Conclusions— Symptoms in patients with severe mitral valve regurgitation relate to congestion (pulmonary capillary wedge pressure and PAP), but not to peak oxygen consumption, which is determined by forward left ventricular stroke volume. Exercise testing reveals a higher mitral valve regurgitation burden in apparently asymptomatic patients. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT02961647.

Layer-specific deformation analysis in severe aortic valve stenosis, primary mitral valve regurgitation, and healthy individuals validated against invasive hemodynamic measurements of heart function

Speckle tracking echocardiography is considered valuable in assessing left ventricular (LV) function. The method has been refined to assess deformation in different myocardial layers, but the effect of volume vs pressure overload on this pattern is unknown. The aim was to test whether layer‐specific myocardial strain (LSS) obtained by speckle tracking echocardiography exhibits different patterns in conditions with different loading conditions.

Incidence of cancer in patients with chronic heart failure

With improvement in survival of chronic heart failure (HF), the clinical importance of co‐morbidity is increasing. The aim of this study was to assess the incidence and risk of cancer and all‐cause mortality in a large Danish HF cohort.

Incidence of cancer in patients with chronic heart failure: a long-term follow-up study: Cancer in patients with chronic HF: long-term follow-up

With improvement in survival of chronic heart failure (HF), the clinical importance of co‐morbidity is increasing. The aim of this study was to assess the incidence and risk of cancer and all‐cause mortality in a large Danish HF cohort.

PROGNOSIS AFTER A DIAGNOSIS OF CANCER IN CHRONIC HEART FAILURE PATIENTS: A LONG TERM FOLLOW-UP STUDY

With improvements in management of chronic heart failure (CHF) more patients survive for extended periods, thus increasing the importance of detection and management of non-cardiac diseases. This study aimed to assess the prognosis after a diagnosis of cancer in a large Danish CHF cohort compared to