Ann Holmes | Researchain

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Featured researches published by Ann Holmes.

Journal of Medicinal Chemistry | 1986

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types

Sylvester R. Klutchko; C. John Blankley; Robert W. Fleming; Jack M. Hinkley; Ann E. Werner; Ivan Nordin; Ann Holmes; Milton Louis Hoefle; David Cohen

Journal of Medicinal Chemistry | 1992

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

Bruce D. Roth; C. J. Blankley; Hoefle Ml; Ann Holmes; W. H. Roark; Bharat K. Trivedi; Arnold D. Essenburg; Karen A. Kieft; Brian R. Krause; Richard L. Stanfield

Journal of Medicinal Chemistry | 1975

Cardioselective beta-adrenergic blocking agents. 1. 1-((3,4-Dimethoxyphenethyl)amino)-3-aryloxy-2-propanols.

Milton Louis Hoefle; S. Hastings; Robert F. Meyer; Ruth M. Corey; Ann Holmes; Charlotte D. Stratton

Journal of Medicinal Chemistry | 1981

Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogues: potent angiotensin converting enzyme inhibitors.

Robert F. Meyer; Ernest. Nicolaides; Francis G. Tinney; Elizabeth A. Lunney; Ann Holmes; Milton Louis Hoefle; Ronald D. Smith; Arnold D. Essenburg; Harvey R. Kaplan; Ronald G. Almquist

Journal of Medicinal Chemistry | 1994

Inhibitors of Acyl-CoA:Cholesterol Acyltransferase (ACAT). 7. Development of a Series of Substituted N-Phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with Enhanced Hypocholesterolemic Activity

Bharat Kalidas Trivedi; Terri Stoeber Purchase; Ann Holmes; Corinne E. Augelli-Szafran; Arnold D. Essenburg; Katherine L. Hamelehle; Richard L. Stanfield; Richard F. Bousley; Brian R. Krause

Archive | 1987

Saturated fatty acid amides as inhibitors of acyl-coa:cholesterol acyltransferase

Milton Louis Hoefle; Ann Holmes; Bruce David Roth

Archive | 1986

Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof

Milton Louis Hoefle; Ann Holmes; Charlotte D. Stratton

Journal of Medicinal Chemistry | 1993

Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond

W. Howard Roark; Bruce David Roth; Ann Holmes; Bharat Kalidas Trivedi; Karen A. Kieft; Arnold D. Essenburg; Brian R. Krause; Richard L. Stanfield

Archive | 1991

Cholecystokinin antagonists, their preparation and therapeutic use

David Christopher Horwell; Edward Roberts; Ann Holmes; Janak Khimchand Padia; William Howard Roark; Bruce David Roth; Bharat Kalidas Trivedi; Jurgen Kleinschroth; David C. Rees; Reginald Stewart Richardson

Drug Metabolism and Disposition | 1997