Anne-Marie D'hondt

Optimal use of dobutamine stress for the detection and evaluation of coronary artery disease: combination with echocardiography or scintigraphy, or both?

OBJECTIVES This study was conducted to examine the efficacy of dobutamine stress two-dimensional echocardiography and perfusion scintigraphy for the detection of coronary artery disease in routine practice, to establish the causes of erroneous results and to derive appropriate criteria for the selection of either or both tests. BACKGROUND Dobutamine stress combined with echocardiography or perfusion scintigraphy may be used to detect coronary artery disease. Although both imaging approaches have demonstrated similar levels of accuracy, it is not known whether there may be particular indications for the use of one or the other technique or a rationale for their combination. METHODS Two hundred seventeen patients without previous infarction were studied prospectively with dobutamine stress echocardiography and technetium-99m methoxy isobutyl nitrile (sestamibi) single-photon emission computed tomography at the time of diagnostic coronary angiography. The presence of coronary stenoses of > or = 50% diameter was compared with the presence of rest or stress-induced abnormalities of perfusion and regional function. The extent of these abnormalities was correlated with an equivalent score of extent of angiographic disease. RESULTS Significant coronary artery disease was found in 142 patients; 102 (72%) were identified by dobutamine echocardiography and 108 (76%, p = NS) by perfusion imaging. In 75 patients without significant disease, the specificity of dobutamine echocardiography was 83% compared with 67% for scintigraphy (p = 0.05). Echocardiographic sensitivity was lower in patients unable to complete the test because of side effects (n = 64) than in the remainder (59% vs. 77%, p = 0.02); this influence was less apparent with scintigraphy (71% vs. 78%, p = NS). Selective use of scintigraphy in the 31 patients with a negative submaximal stress echocardiogram led to a sensitivity of 80% for this combination. Patients with left ventricular hypertrophy accounted for most of the difference in specificity between echocardiography and scintigraphy (94% vs. 59%, p = 0.02). Their respective accuracies were 76% and 73%. CONCLUSIONS Dobutamine stress echocardiography and perfusion scintigraphy have equivalent accuracy. In patients with left ventricular hypertrophy, echocardiography appears to be the test of choice. Selective use of sestamibi scintigraphy in patients with a negative submaximal echocardiogram enhances the accuracy of stress echocardiography alone.

Selection of the optimal nonexercise stress for the evaluation of ischemic regional myocardial dysfunction and malperfusion. Comparison of dobutamine and adenosine using echocardiography and 99mTc-MIBI single photon emission computed tomography.

BackgroundThe mechanisms of action of exercise-simulating and vasodilator stressors support their combination with imaging techniques that evaluate left ventricular function and perfusion, respectively. However, reported accuracies of either pharmacological stress together with two-dimensional echocardiography (2DE) or single photon emission computed tomography (SPECT) of myocardial perfusion are similar. The purpose of this study was to establish the optimal stress for each imaging technique by comparing the results of digitized 2DE and 99mTc-methoxyisobutyl isonitrile (MIBI) SPECT using both dobutamine and adenosine stresses in the same patients and conditions. Methods and ResultsNinety-seven consecutive patients without evidence of previous infarction undergoing coronary angiography for clinical indications were studied prospectively. Dobutamine was infused during clinical, ECG, and echocardiographic monitoring in dose increments from 5 to 40 μg kg-1 min-1. Adenosine was infused under the same conditions in doses of 0.10, 0.14, and 0.18 mg

Head-to-head comparison of exercise-redistribution-reinjection thallium single-photon emission computed tomography and low dose dobutamine echocardiography for prediction of reversibility of chronic left ventricular ischemic dysfunction.

kg-1min-1. For each protocol, the end points were achievement of peak dose, development of severe ischemia, or intolerable side effects. At peak stress, 20 mCi of MIBI was injected, and SPECT imaging was performed 2 hours later, abnormal poststress images were compared with resting SPECT. Digitized 2DE images were compared qualitatively before, during, and after stress in a cine-loop display. Significant coronary disease (n=59 patients) was defined by the quantification of >50% stenosis in a major epicardial vessel. The sensitivity of adenosine 2DE was 58%, less than those of adenosine MIBI (86%, p=0.001), dobutamine 2DE (85%, p=0.001), and dobutamine MIBI (80%, p=0.01). Their respective specificities were 87%, 71%, 82%, and 74% (p=NS). The accuracy of adenosine 2DE was 69%Y, compared with 80%Yo for adenosine MIBI (p<0.001), 84% for dobutamine 2DE (p=0.001), and 77% for dobutamine MIBI (p=0.005); the latter three did not differ significantly in either sensitivity or accuracy. ConclusionThis prospective, direct comparison of alternative pharmacological stresses in patients without myocardial infarction shows vasodilator stress scintigraphy and dobutamine stress echocardiography and scintigraphy to share equivalent levels of sensitivity. All three are significantly more sensitive than adenosine stress echocardiography. Dobutamine stress may be used for wall motion or perfusion imaging, but adenosine stress is best combined with perfusion scintigraphy.

Prognostic Value of Myocardial Ischemia and Viability in Patients With Chronic Left Ventricular Ischemic Dysfunction

OBJECTIVES We sought to directly compare the diagnostic value of exercise-redistribution-reinjection thallium single-photon emission computed tomography (SPECT) and low dose dobutamine echocardiography for prediction of contractile recovery after revascularization. BACKGROUND Both thallium SPECT and dobutamine echocardiography have been proposed to predict the reversibility of left ventricular dysfunction after revascularization. Although both techniques permit differentiation of viable from nonviable myocardium, few studies have directly compared their accuracy in the same patients. METHODS Seventy-three consecutive patients (mean [+/- SD] age 59 +/- 9 years) with coronary disease and regional left ventricular dysfunction underwent exercise-redistribution-reinjection thallium SPECT and dobutamine echocardiography before revascularization. Recovery of function was evaluated with echocardiography 5.5 +/- 2.5 months after revascularization. For analysis, the left ventricle was divided into 16 segments, in which percent thallium uptake was quantitated using circumferential profiles, and regional wall motion was graded semiquantitatively (normal = 1; akinetic = 3). RESULTS The diagnostic performance of the two tests was investigated both for individual patients and for individual segments. Individual patient analysis showed that left ventricular ejection fraction improved > 5% after revascularization in 43 patients, whereas 30 showed no change. Receiver operating characteristic curves were used to select optimal criteria for prediction of functional recovery after revascularization. According to a mean thallium uptake > 54% at reinjection, SPECT had a sensitivity of 72%, a specificity of 73% and an overall accuracy of 73%. Similarly, according to an improvement in wall motion score > 3.5 grades during doubutamine echocardiography, echocardiography had a sensitivity of 88%, a specificity of 77% and an overall accuracy of 84% (p = NS vs. thallium). Segmental analysis showed that SPECT and dobutamine echocardiography had similar sensitivity (77% and 75%, respectively), but SPECT had lower specificity (56% vs. 86%, p < 0.01). CONCLUSIONS Quantitative exercise-redistribution-reinjection thallium SPECT and dobutamine echocardiography have comparable accuracy for prediction of reversibility of global left ventricular dysfunction after revascularization. However, dobutamine echocardiography has greater specificity than thallium imaging for prediction of functional recovery on a segmental basis.

Comparison of myocardial contrast echocardiography with NC100100 and 99m Tc sestamibi SPECT for detection of resting myocardial perfusion abnormalities in patients with previous myocardial infarction

BACKGROUND Previous studies showed that thallium scintigraphy and dobutamine echocardiography were accurate, noninvasive ways of predicting contractile recovery after revascularization in patients with left ventricular (LV) dysfunction. However, the prognostic impact of such methods remains uncertain. METHODS AND RESULTS We prospectively studied 137 consecutive patients with coronary disease and LV dysfunction who underwent exercise-redistribution-reinjection thallium scintigraphy and dobutamine echocardiography to identify myocardial ischemia and viability. A total of 94 patients subsequently underwent revascularization, and 43 underwent medical treatment. The primary endpoint was cardiac mortality, and mean follow-up was 33+/-10 months. Twenty-four patients died of cardiac causes. By Coxs regression analysis, long-term survival was related to the extent of coronary disease, the presence of diabetes, type of treatment, the presence of ischemic myocardium as determined by thallium scintigraphy, and the presence of viable myocardium as determined by both tests. Three-year survival was greater in patients with ischemic myocardium (as determined by thallium scintigraphy) or viable myocardium (as determined by both tests) who underwent revascularization than in the other groups (P=0.018 with thallium; P<0.001 with dobutamine). Subgroup analyses indicated that among patients with 1- or 2-vessel disease, only those with ischemic or viable myocardium improved survival after revascularization, whereas in patients with 3-vessel or left main diseases, revascularization always improved survival, albeit more in the presence of ischemic or viable myocardium. CONCLUSIONS Among the parameters commonly available in patients with LV ischemic dysfunction, the presence of ischemic myocardium (as determined by thallium scintigraphy) and that of viable myocardium (as determined by dobutamine echocardiography) are independent predictors of subsequent mortality. These observations may be useful in the preoperative selection of patients for revascularization.

Relation of ultrasonic tissue characterization with integrated backscatter to contractile reserve in chronic left ventricular ischemic dysfunction.

OBJECTIVE To determine whether myocardial contrast echocardiography (MCE) following intravenous injection of perfluorocarbon microbubbles permits identification of resting myocardial perfusion abnormalities in patients who have had a previous myocardial infarction. PATIENTS AND INTERVENTIONS 22 patients (mean (SD) age 66 (11) years) underwent MCE after intravenous injection of NC100100, a novel perfluorocarbon containing contrast agent, and resting99mTc sestamibi single photon emission computed tomography (SPECT). With both methods, myocardial perfusion was graded semiquantitatively as 1 = normal, 0.5 = mild defect, and 0 = severe defect. RESULTS Among the 203 normally contracting segments, 151 (74%) were normally perfused by SPECT and 145 (71%) by MCE. With SPECT, abnormal tracer uptake was mainly found among normally contracting segments from the inferior wall. By contrast, with MCE poor myocardial opacification was noted essentially among the normally contracting segments from the anterior and lateral walls. Of the 142 dysfunctional segments, 87 (61%) showed perfusion defects by SPECT, and 94 (66%) by MCE. With both methods, perfusion abnormalities were seen more frequently among akinetic than hypokinetic segments. MCE correctly identified 81/139 segments that exhibited a perfusion defect by SPECT (58%), and 135/206 segments that were normally perfused by SPECT (66%). Exclusion of segments with attenuation artefacts (defined as abnormal myocardial opacification or sestamibi uptake but normal contraction) by either MCE or SPECT improved both the sensitivity (76%) and the specificity (83%) of the detection of SPECT perfusion defects by MCE. CONCLUSIONS The data suggest that MCE allows identification of myocardial perfusion abnormalities in patients who have had a previous myocardial infarction, provided that regional wall motion is simultaneously taken into account.

Usefulness of low-dose dobutamine echocardiography for selection of patients with severely depressed left ventricular function for coronary bypass grafting

Previous studies have shown that viable but stunned myocardium displays contractile reserve and exhibits cardiac cycle-dependent variations of integrated backscatter, whereas infarcted myocardium does not. The present study was designed to evaluate whether integrated backscatter imaging could be useful in identifying segments with recruitable inotropic reserve in patients with chronic left ventricular (LV) ischemic dysfunction. We studied 15 patients (mean age 59 +/- 10 years) with chronic coronary artery disease, anterior or inferior wall dysfunction, and depressed LV ejection fraction (35 +/- 12%), and 6 noncardiac control subjects (mean age 49 +/- 18 years). Cardiac cycle-dependent variations of integrated backscatter were measured in anterior and inferior segments during transesophageal echocardiography and compared with the contractile response (% wall thickening) of these segments to low doses of dobutamine (5 to 10 microg/kg/min). The average magnitude of cardiac cycle-dependent variations of integrated backscatter was greater among normally contracting segments of both patients and controls (5.67 +/- 0.88 and 5.64 +/- 2.26 dB, respectively, p = NS) than among dysfunctional segments (2.77 +/- 3.05 dB, p <0.01 vs control and remote segments). Dysfunctional segments were further categorized into those with and without dobutamine-induced contractile reserve. At baseline, systolic wall thickening was similar among segments responding to dobutamine than among those that did not (3.6 +/- 2.3% vs 2.9 +/- 1.6%, p = NS). During dobutamine, systolic wall thickening increased only in segments showing improvement in wall motion score (to 24.5 +/- 4.7%), whereas it remained unchanged in segments not responding to dobutamine (to 2.0 +/- 3.7%, p <0.01). The magnitude of resting cardiac cycle-dependent variations of integrated backscatter was larger in segments responding to dobutamine than in those with persistent dysfunction (5.31 +/- 2.06 vs 0.23 +/- 0.94 dB, p <0.01) and correlated significantly (r = 0.74, p <0.01) with systolic wall thickening during dobutamine. Our data demonstrate that resting cardiac cycle-dependent variations of integrated backscatter closely parallel contractile reserve in patients with chronic LV ischemic dysfunction. This suggests that tissue characterization with integrated backscatter could be a useful adjunct to the delineation of myocardial viability in these patients.

The transmural extent of necrosis modulates the contractile response of metabolically viable myocardium to dobutamine

P the beneficial effects of revascularization result from restoring blood supply to dysfunctional but viable myocardial regions with subsequent improvement in regional and global left ventricular (LV) function. During the past decade, delineation of viable from nonviable myocardium has been the focus of considerable attention and has fostered the development of several new modalities aimed at predicting the return of LV function after revascularization. Among these modalities, low-dose dobutamine echocardiography has recently emerged as a safe, noninvasive, and accurate means of identification of viable myocardium. Although existing data suggest that low-dose dobutamine echocardiography is useful in predicting outcome in patients with moderately depressed LV function, there are no data regarding the prognostic impact of this modality in patients with severe LV dysfunction (i.e., an ejection fraction 25%). Accordingly, the aim of the present study was to evaluate the prognostic value of low-dose dobutamine echocardiography in patients with severely depressed LV function undergoing coronary bypass grafting (CABG).

Assessment of the physiologic significance of coronary disease With dipyridamole real-time myocardial contrast echocardiography: Comparison With Technetium-99m sestamibi single-photon emission computed tomography and quantitative coronary angiography

Background: Both positron emission tomography (PET) and low-dose dobutamine echocardiography (LDE) have been proposed to assess the presence of viable myocardium. Although both of these modalities share the same final purpose, i.e. to predict which segment is likely to resume contractile function following revascularization, they frequently disagree on the presence of segmental viability. In particular, many segments with preserved metabolic viability lack evidence of contractile reserve during LDE. The am of this study was lo determine whether small subendocardial infarcts might contribute to the lack of inotropic reserve in metabolically viable myocardium. Methods: Thirteen patients (10 M. 60+11 years) with CAD and altered cardiac function (EF X+15%) underwent FDG-PET. LDE and Gd-enhanced MRI for the assessment of mvocardial viability. Baseline contractile function, inotropic reserve (LDE) and the transmural extent of necrosis Iouantitative late-enhancement MRI) were cornoared amona PET viable (>60%