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Annette K. Kwok

Johnson & Johnson Pharmaceutical Research and Development

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Featured researches published by Annette K. Kwok.

Bioorganic & Medicinal Chemistry Letters | 2003

Non-imidazole heterocyclic histamine H3 receptor antagonists.

Wenying Chai; J. Guy Breitenbucher; Annette K. Kwok; Xiaobing Li; Victoria Wong; Nicholas I. Carruthers; Timothy W. Lovenberg; Curt Mazur; Sandy J. Wilson; Frank U. Axe; Todd K. Jones

Continued exploration of the SAR around the lead imidazopyridine histamine H(3) antagonist 1 has led to the discovery of several related series of heterocyclic histamine H(3) antagonists. The synthesis and SAR of indolizine, indole and pyrazolopyridine based compounds are now described.

Journal of Medicinal Chemistry | 2003

The first potent and selective non-imidazole human histamine H4 receptor antagonists.

Jill A. Jablonowski; Cheryl A. Grice; Wenying Chai; Curt A. Dvorak; Jennifer D. Venable; Annette K. Kwok; Kiev S. Ly; Jianmei Wei; Sherry M. Baker; Pragnya J. Desai; Wen Jiang; Sandy J. Wilson; Robin L. Thurmond; Lars Karlsson; James P. Edwards; Timothy W. Lovenberg; Nicholas I. Carruthers

Journal of Medicinal Chemistry | 2005

Preparation and Biological Evaluation of Indole, Benzimidazole, and Thienopyrrole Piperazine Carboxamides: Potent Human Histamine H4 Antagonists

Jennifer D. Venable; Hui Cai; Wenying Chai; Curt A. Dvorak; Cheryl A. Grice; Jill A. Jablonowski; Chandra R. Shah; Annette K. Kwok; Kiev S. Ly; Barbara Pio; Jianmei Wei; Pragnya J. Desai; Wen Jiang; Steven Nguyen; Ping Ling; Sandy J. Wilson; Paul J. Dunford; Robin L. Thurmond; Timothy W. Lovenberg; Lars Karlsson; Nicholas I. Carruthers; James P. Edwards

Journal of Pharmacology and Experimental Therapeutics | 2002

Reconsideration of 5-Hydroxytryptamine (5-HT)7Receptor Distribution Using [3H]5-Carboxamidotryptamine and [3H]8-Hydroxy-2-(di-n-propylamino)tetraline: Analysis in Brain of 5-HT1A Knockout and 5-HT1A/1B Double-Knockout Mice

Pascal Bonaventure; Diane Nepomuceno; Annette K. Kwok; Wenying Chai; Xavier Langlois; René Hen; Kimberly L. Stark; Nicholas I. Carruthers; Timothy W. Lovenberg

Archive | 2001

Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines

Richard Apodaca; Nicholas I. Carruthers; John R. Carson; Wenying Chai; Annette K. Kwok; Xiaobing Li; Timothy W. Lovenberg; Dale A. Rudolph; Chandravadan R. Shah

Archive | 2001

Phenyl-substituted indolizines and tetrahydroindolizines

Wenying Chai; Annette K. Kwok; Xiaobing Li; Dale A. Rudolph

Archive | 2005

Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine

Richard Apodaca; Nicholas I. Carruthers; John R. Carson; Wenying Chai; Annette K. Kwok; Xiaobing Li; Timothy W. Lovenberg; Dale A. Rudolph; Chandravadan R. Shah

Archive | 2004

Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors Fused heterocyclic compounds as modulators of the serotonin receptor expression

Nicholas I. Carruthers; Wenying Chai; Xiaohu Deng; Curt A. Dvorak; Annette K. Kwok; Jimmy T. Liang; Neelakandha S. Mani; Dale A. Rudolph; Victoria Wong

Archive | 2003