Annette Nicholls

Concentration and partial characterization of human salivary gastrone

SummaryAn inhibitor of gastric-acid secretion has been purified from human saliva and its activity concentrated 30-fold. Inactive material has been removed from saliva by extraction into phenol, by digestion with protease, by heat precipitation, and by prolonged dialysis. The final preparation contained polysaccharide or mucopolysaccharide of molecular weight in excess of 100,000, as well as traces of sialic acid and protein.

Effect of nitrogen mustard on gastric secretion in the rat

SummaryThe effect of nitrogen mustard on gastric secretion was studied using a pylorus-ligated rat preparation. Nitrogen mustard caused temporary reduction in the volume of gastric secretion and also caused a significant decrease in the output of acid by the rat stomach. The possible causes of these effects are discussed.

Blood Volume in Malignant Disease: Case Studies in 86 Females1

The problem of blood replacement in the individual cancer patient remains unanswered. On present evidence, such a patient must be assumed to be drawn from a population with a mean total blood volume and mean red-cell volume below normal and thus must be assumed to have a better-than-even chance of having a depleted volume. However, it does not necessarily follow that transfusion is necessary; this should ideally be assessed by blood volume determination in each individual case.

INHIBITION BY GASTRONE OF RAT GASTRIC ACID SECRETION MAXIMALLY STIMULATED BY 2-DEOXY-D-GLUCOSE

INHIBITION BY GASTRONE OF RAT GASTRIC ACID SECRETION MAXIMALLY STIMULATED BY 2-DEOXY-D-GLUCOSE