Peter Baume

Stiff-man syndrome presenting with complete esophageal obstruction. Report of a case.

A patient with stiff-man syndrome presenting with complete esophageal obstruction is discussed. The excellent therapeutic response to diazepam is important and is the main reason for drawing the attention of gastroenterologists to this manifestation of stiff-man syndrome. The stiff-man syndrome should be added to the unusual causes of complete upper esophageal obstruction.

Concentration and partial characterization of human salivary gastrone

SummaryAn inhibitor of gastric-acid secretion has been purified from human saliva and its activity concentrated 30-fold. Inactive material has been removed from saliva by extraction into phenol, by digestion with protease, by heat precipitation, and by prolonged dialysis. The final preparation contained polysaccharide or mucopolysaccharide of molecular weight in excess of 100,000, as well as traces of sialic acid and protein.

Isoenzymes of lactate dehydrogenase in human gastric mucosa and gastric carcinoma tissue.

Lactate dehydrogenase (LDH) isoenzymes were demonstrated electrophoretically in human fundic and pyloric gastric mucosae and in gastric carcinoma tissue. Fundic gastric mucosa consistently displayed a pattern with predominance of LD1, LD2, and LD3. Pyloric gastric mucosa and cancer tissue consistently had identical patterns with a predominance of LD2, LD3, and LD4, differing significantly from the LDH isoenzyme pattern of fundic mucosa. The LDH isoenzyme pattern characteristic of fundic mucosa extended very close to the histological junction between body and pyloric gastric mucosa and was not affected by the presence of gastritis in the stomach. These results serve to demonstrate yet another difference between mucosa from the acid-secreting and the pyloric areas of the human stomach.

The effect of nitrogen mustard and cyclophosphamide on gastric secretion in man

Summary1. Nitrogen mustard caused achlorhydria, by the criteria of the Diagnex Blue tubeless test, in 7 of 8 patients given the drug for cancer.2. The achlorhydria lasted less than 3 weeks.3. Cyclophosphamide had no demonstrable effect on gastric secretion.4. The mode of action of nitrogen mustard and the reason for the failure of cyclophosphamide to inhibit gastric secretion are discussed.1. Nitrogen mustard caused achlorhydria, by the criteria of the Diagnex Blue tubeless test, in 7 of 8 patients given the drug for cancer. 2. The achlorhydria lasted less than 3 weeks. 3. Cyclophosphamide had no demonstrable effect on gastric secretion. 4. The mode of action of nitrogen mustard and the reason for the failure of cyclophosphamide to inhibit gastric secretion are discussed.

Effect of nitrogen mustard on gastric secretion in the rat

SummaryThe effect of nitrogen mustard on gastric secretion was studied using a pylorus-ligated rat preparation. Nitrogen mustard caused temporary reduction in the volume of gastric secretion and also caused a significant decrease in the output of acid by the rat stomach. The possible causes of these effects are discussed.

Constancy of gastric secretion measured by a tubeless technic.

1. Gastric secretion was estimated serially using Diagnex Blue in a group of subjects with no alimentary symptoms. Three types of stimulus to gastric secretion were used. 2. Serial testing of people with free acid revealed wide variation in the quantitative excretion of dye, and confirmed the impression that the test is a poor quantitative measure of gastric secretion. 3. As a result of the test the subjects were divided into groups called “achlorhydric” and “normal” depending on their excretion of azure A dye. A third, intermediate, group of uncertain significance was also recognized. 4. Serial testing showed that normal subjects remained in the same group; that is, they did not change from normal on the second or subsequent tests. 5. It has been suggested that the Diagnex Blue test provides a convenient means of assessing qualitative alterations in gastric secretion.Summary1. Gastric secretion was estimated serially using Diagnex Blue in a group of subjects with no alimentary symptoms. Three types of stimulus to gastric secretion were used.2. Serial testing of people with free acid revealed wide variation in the quantitative excretion of dye, and confirmed the impression that the test is a poor quantitative measure of gastric secretion.3. As a result of the test the subjects were divided into groups called “achlorhydric” and “normal” depending on their excretion of azure A dye. A third, intermediate, group of uncertain significance was also recognized.4. Serial testing showed that normal subjects remained in the same group; that is, they did not change from normal on the second or subsequent tests.5. It has been suggested that the Diagnex Blue test provides a convenient means of assessing qualitative alterations in gastric secretion.

INHIBITION BY GASTRONE OF RAT GASTRIC ACID SECRETION MAXIMALLY STIMULATED BY 2-DEOXY-D-GLUCOSE

INHIBITION BY GASTRONE OF RAT GASTRIC ACID SECRETION MAXIMALLY STIMULATED BY 2-DEOXY-D-GLUCOSE