Anthony A. Scaduto

Perioperative complications of threaded cylindrical lumbar interbody fusion devices: anterior versus posterior approach.

Few data are available to evaluate approach-related differences in perioperative complications with lumbar interbody fusion devices. Complications occurring in the intraoperative and immediate postoperative period were identified and categorized for 31 consecutive posterior lumbar interbody fusions (PLIFs) and 88 consecutive anterior lumbar interbody fusions (ALIFs). In this study, all lumbar interbody fusions were conducted with threaded cylindrical devices as stand-alone internal fixation devices. Multivariate analysis was used to account for potential covariates and identify factors associated with an increased complication risk. Twenty-two percent of the patients had a perioperative complication. The relative risk of having a perioperative complication was 4.75 times higher for the PLIF group. All intraoperative complications occurred in the PLIF group. The relative risk of having a major postoperative complication was 6.8 times higher in the PLIF group than the ALIF group. Anterior approached patients tended to have visceral (ileus, 6%) and vascular (deep venous thrombosis, 2%) complications. In the posterior group, complications were neurologic and dura related (pseudomeningocele, 16%; epidural hematoma, 3%) and occurred most frequently in patients that had had previous posterior lumbar surgery (31% with major complication).

GENE THERAPY FOR OSTEOINDUCTION

One application of gene therapy that holds great promise is the stimulation of bone formation. Gene therapy offers several potential advantages over other methods of osteoinduction and current research suggests that it may be a feasible treatment option for the orthopedic surgeon in the near future. This article reviews the basic concepts and strategies of gene therapy and evaluates the current research using gene therapy to induce bone formation and enhance healing.

Efficacy of intraoperative cell salvage systems in pediatric idiopathic scoliosis patients undergoing posterior spinal fusion with segmental spinal instrumentation.

Study Design. Retrospective case–control study. Objective. Determine whether intraoperative cell salvage system use during pediatric posterior spinal fusion (PSF) with segmental spinal instrumentation for idiopathic scoliosis decreases intraoperative and perioperative (intraoperative plus postoperative) allogeneic blood transfusion. Summary of Background Data. Intraoperative cell salvage and reinfusion can reduce or obviate perioperative allogeneic blood transfusion. Despite these benefits, their efficacy in pediatric PSF is unclear. Reported complications include transient hematuria, altered hemostasis, and electrolyte imbalance. Methods. A total of 54 consecutive idiopathic scoliosis patients were studied: 21 non-cell saver and 33 cell saver patients. Data included age, body mass index, Cobb angle, perioperative hemoglobin levels, mean arterial pressure, surgical time, levels fused, perioperative estimated blood loss, and perioperative transfusions. A &khgr;2 and t tests were performed for intraoperative and perioperative allogeneic transfusion between groups. A regression analysis was performed between selected covariates and allogeneic transfusion. Relative risk analysis examined significant covariates regarding allogeneic transfusion rate. Results. Allogeneic transfusion rates were lower in the cell saver group (6% vs. 55% intraoperative and 18% vs. 55% perioperative, P < 0.05). Mean allogeneic transfusion volumes (mL/kg) were also lower (0.4 vs. 9.1 intraoperative and 1.9 vs. 11.1 perioperative, P < 0.05). Multivariate analysis confirmed these differences were independent of perioperative blood loss, and also demonstrated that surgical time and blood loss were significantly related to allogeneic transfusion volume. The allogeneic transfusion relative risk was 2.04 in patients with surgery >6 hours and 5.87 in patients not receiving cell saver blood. All patients with surgeries >6 hours and estimated blood loss >30% of total blood volume received cell saver system blood. Conclusion. Cell saver use decreased allogeneic transfusion, particularly in surgeries >6 hours with estimated blood loss >30% of total blood volume. This study confirms the utility of routine cell saver use during PSF with segmental spinal instrumentation for idiopathic scoliosis.

Influence of gait analysis on decision-making for lower extremity orthopaedic surgery: Baseline data from a randomized controlled trial §

Previous studies examining the influence of gait analysis on surgical decision-making have been limited by the lack of a control group. The aim of this study was to use data from a randomized controlled trial to determine the effects of gait analysis on surgical decision-making in children with cerebral palsy (CP). 178 ambulatory children with CP (110 male; age 10.3±3.8 years) being considered for lower extremity orthopaedic surgery underwent gait analysis and were randomized into one of two groups: gait report group (N=90), where the orthopaedic surgeon received the gait analysis report, and control group (N=88), where the surgeon did not receive the gait report. Data regarding specific surgeries were recorded by the treating surgeon before gait analysis, by the gait laboratory surgeon after gait analysis, and after surgery. Agreement between the treatment done and the gait analysis recommendations was compared between groups using the 2-sided Fishers Exact test. When a procedure was planned initially and also recommended by gait analysis, it was performed more often in the gait report group (91% vs. 70%, p<0.001). When the gait laboratory recommended against a planned procedure, the plan was changed more frequently in the gait report group (48% vs. 27%, p=0.009). When the gait laboratory recommended adding a procedure, it was added more frequently in the gait report group (12% vs. 7%, p=0.037). These results provide a stronger level of evidence demonstrating that gait analysis changes treatment decision-making and also reinforces decision-making when it agrees with the surgeons original plan.

Outcomes of lower extremity orthopedic surgery in ambulatory children with cerebral palsy with and without gait analysis: Results of a randomized controlled trial

This study examined the impact of gait analysis on surgical outcomes in ambulatory children with cerebral palsy (CP) through a randomized controlled trial. 156 children with CP (94 male; age 10.2 ± 3.7 years) underwent gait analysis and were randomized to two groups: Gait Report group (N = 83), where the referring surgeon received the patients gait analysis report, and Control group (N = 73), where the surgeon did not receive the gait report. Outcomes were assessed pre- and 1.3 ± 0.5 years post-operatively. An intent-to-treat analysis compared outcomes between the two groups. Outcome measures included the Gillette Functional Activity Questionnaire (FAQ), Gait Deviation Index (GDI), oxygen cost, gross motor function measure, Child Health Questionnaire (CHQ), Pediatric Outcomes Data Collection Instrument (PODCI), and Pediatric Evaluation and Disability Inventory. The outcomes that differed significantly between groups were change in health from the CHQ, which was rated as much better for 56% (46/82) of children in the Gait Report group compared with 38% (28/73) in the Control group (p = 0.04), and upper extremity physical function from the PODCI. Gait outcomes (FAQ and GDI) improved more when over half of the recommendations for a patient were followed or the recommended extent of surgery (none, single, or multi-level) was done (p ≤ 0.04). On average, however, only 42% of the recommendations were followed in the Gait Report group, compared with 35% in the Control group (p = 0.23). This is much less than the >85% reported in previous studies and may account for the lack of differences between groups for some of the outcome measures.

Assessment of trunk balance in thoracic scoliosis

Study Design. A retrospective radiographic review was undertaken in patients with idiopathic thoracic scoliosis. Objectives. To determine if a mathematical relationship exists between the 2 methods used to assess trunk balance (lateral trunk shift [LTS] and thoracic apical vertebral translation [AVT]), and to determine if one of these measurements can satisfactorily predict the value of the other. Summary of Background Data. No previous reports exist, to our knowledge, comparing these 2 methods used to asess trunk balance. Methods. Coronal balance (CB), LTS, thoracic AVT, and curve magnitude were measured from standing preoperative posteroanterior radiographs of 91 patients with Lenke 1A/1B curves. The data were analyzed to determine if predictive relationships existed between LTS and thoracic AVT alone or between LTS and the sum of CB and thoracic AVT. Results. A statistically significant relationship was shown between LTS and the sum of thoracic AVT and CB. In general, the LTS can be estimated by taking two thirds of the sum of thoracic AVT and CB (in centimeters) and subtracting 0.8. This relationship weakened as CB improved. The relationship between LTS and AVT was not statistically significant when CB was excluded. Conclusions. In patients with thoracic idiopathic scoliosis, if the CB and thoracic AVT values are known, then the LTS can be reliably estimated. The use of correct terminology for describing trunk balance and CB is important if valid comparisons of spinal deformity literature are desired.

Quantification of Increase in Three-dimensional Spine Flexibility Following Sequential Ponte Osteotomies in a Cadaveric Model

BACKGROUND Posterior-only procedures are becoming more popular for treatment of rigid adolescent idiopathic scoliosis, but little is known about the quantitative correction potential for Ponte osteotomies. The objective of this study was to quantify and compare the range of motion of intact multilevel thoracic spine segments with the same segments after each of 3 sequential Ponte osteotomies. METHODS We tested 5 human cadaveric thoracic spine segments, spanning T-T6, or T7-T12, in an 8-degree-of-freedom servo-hydraulic load frame, monitoring motion of each vertebra with an optical motion tracker. We measured range of motion while we applied cyclic, pure moment loading to produce flexion-extension, lateral bending, and axial rotation at a rate of 0.5°/second, to a maximum of ± 6 Nm. Each specimen was tested intact and after each of 3 sequential Ponte osteotomies. RESULTS Total range of motion for the segments (either T2-T5 or T8-T11) increased by as much as 1.6° in flexion, 1.5° in extension, 0.5° in lateral bending, and 2.8° in axial rotation with each osteotomy. Because of the variation in initial specimen stiffness, we normalized motions to the intact values. In flexion, average range of motion increased after each osteotomy compared with intact, by 33%, 56%, and 69%. In extension, slightly smaller increases were seen, increasing by as much as 56% after the third osteotomy. In lateral bending, Ponte osteotomies had little effect on range of motion. In axial rotation, range of motion increased by 16%, 29%, and 65% after 3 osteotomies. CONCLUSIONS Sequential Ponte osteotomies increased range of motion in flexion, extension, and axial rotation, but not in lateral bending. These results suggest that the Ponte osteotomy may be appropriate when using derotational correction maneuvers, or to improve apical lordosis at the apex of curvature during posterior spinal fusion procedures. Although these techniques are effective in gaining correction for kyphotic deformities and rigid curvatures, they add time and blood loss to the procedure.

Accessory soleus muscle as a cause of resistance to correction in congenital club foot: a case report.

A 14-month-old female with bilateral clubfeet was initially treated by serial casting and percutaneous tenotomy of the Achilles tendon, bilaterally. Both clubfeet subsequently underwent surgical treatment with a posteromedial release through a Cincinnati incision. At surgery on one clubfoot, an accessory Soleus muscle was found anterior to the Achilles tendon with a distinct insertion on the upper surface of calcaneus, anterior and medial to the insertion of Achilles tendon. This accessory Soleus muscle may have been the cause of resistance to correction in this congenital clubfoot.

Concurrent and discriminant validity of Spanish language instruments for measuring functional health status.

Background: Questionnaires translated into languages other than English are often not validated to the same extent as the English versions. This study examined the concurrent and discriminant validity of selected domains related to physical function from Spanish language versions of the Child Health Questionnaire (CHQ), Pediatric Outcomes Data Collection Instrument (PODCI), and Pediatric Evaluation and Disability Inventory (PEDI). Methods: Concurrent validity was examined in 93 children with cerebral palsy by correlating questionnaire domain scores with Gross Motor Function Measure and Gillette Functional Assessment Questionnaire walking scale scores. Discriminant validity with respect to Gross Motor Function Classification System (GMFCS) level was examined using analysis of variance and nonparametric discriminant analysis. Results: Concurrent validity was demonstrated for 3 domains from the PEDI (Mobility functional skills, &tgr; = 0.62; Mobility caregiver assistance, &tgr; = 0.46-0.55; and Self-care functional skills, &tgr; = 0.30-0.36), 3 domains from the PODCI (Sports and physical function, &tgr; = 0.48-0.51; Transfer and basic mobility, &tgr; = 0.48-0.51; and Upper extremity physical function, &tgr; = 0.28), and 1 domain from the CHQ (Physical function, &tgr; = 0.31-0.36). Discriminant validity was demonstrated for the same domains based on significant decreases in domain scores with increasing GMFCS level. Discriminant validity was highest for the PODCI, which correctly classified 98% (91/93) of subjects into the correct GMFCS level when all 3 domains were considered. Conclusions: For the first time, concurrent validity and discriminant validity have been demonstrated for the physical function domains of Spanish language versions of the PODCI, PEDI, and CHQ questionnaires. PODCI and PEDI had the highest concurrent validity, and PODCI had the best discriminant ability. Clinical Relevance: It is important to examine the validity of instruments when they have been translated from English into other languages. This importance will only increase as the population of non-English-speaking patients expands.

Does early thoracic fusion exacerbate preexisting restrictive lung disease in congenital scoliosis patients

Background: Congenital thoracic scoliosis is associated with diminished pulmonary function. Early posterior thoracic spinal fusion surgery may additionally impact pulmonary function beyond the natural history of the disease by further inhibiting thoracic growth. The primary study aim is to determine if early thoracic spine fusion patients have diminished pulmonary function versus untreated patients at a similar age. The secondary study aim is to determine how plain radiographic measurements of thoracic deformity change over time and correlate to pulmonary function in these patients. Methods: Sequential spinal radiographs and one-time pulmonary function tests were performed in 43 consecutive congenital thoracic scoliosis patients with either a history of early posterior thoracic fusion or no surgery. Multiple stepwise t testing compared the patient-related and radiographic variables in the early surgery and no surgery groups. Multiple stepwise linear regression analysis examined the effect of the variables at final follow-up on forced vital capacity and forced expiratory volume. Results: All patients exhibited decreased forced vital capacity, but there was no difference between early surgery and no surgery groups at an average follow-up age of 10.5 years. A mid- (versus low) thoracic apex, decreased space available for the lung, and decreased age-corrected thoracic width correlated with decreased forced vital capacity. Between initial and final radiographic follow-up, the rate of change in thoracic height and width was decreased in the early surgery versus no surgery group. Conclusions: Early posterior spinal fusion decreases radiographic measures of thoracic growth over time, but pulmonary function was similar to untreated patients at 10.5 years of age. The data suggest pulmonary function and thoracic size as measured on plain radiographs correlate directly. Therefore, pulmonary function testing at the end of growth should be performed to determine the ultimate pulmonary consequences of early surgery. Level of Evidence: Prognostic case-control study, Level III.