Antonio Micari

Serum levels of osteoprotegerin and RANKL in patients with ST elevation acute myocardial infarction.

OPG (osteoprotegerin) has been suggested to have an important role in atherogenesis and vascular calcification. In the present study, we have investigated serum OPG and RANKL (receptor activator of nuclear factor kappaB ligand) concentrations in patients with ST elevation AMI (acute myocardial infarction) and established CAD (coronary artery disease). OPG and RANKL were measured in 58 male patients hospitalized in the coronary care unit with ST elevation AMI, in 52 asymptomatic male patients with an established diagnosis of CAD and in 52 healthy male controls. These last two groups were matched with the AMI patients for age and body mass index. OPG was significantly (P<0.05) higher in patients with AMI at 1 h after AMI (8.04+/-4.86 pmol/l) than in both patients with established CAD (4.92+/-1.65 pmol/l) and healthy subjects (3.15+/-1.01 pmol/l). Subjects with established CAD had significantly (P<0.05) increased OPG levels compared with controls. RANKL levels in patients with established CAD (0.02+/-0.05 pmol/l) and with AMI (0.11+/-0.4 pmol/l) were significantly (P<0.05) lower compared with controls (0.32+/-0.35 pmol/l). In the AMI group, OPG decreased significantly (P<0.05) at 1 and 4 weeks after infarction (8.04+/-4.86 compared with 6.38+/-3.87 and 6.55+/-2.6 pmol/l respectively), but OPG levels, either at 1 h or 1-4 weeks after AMI, remained significantly (P<0.05) higher compared with established CAD (4.92+/-1.65 pmol/l) and controls (3.15+/-1.01 pmol/l). Our data show for the first time that OPG levels are increased in ST elevation AMI within 1 h of infarction. Whether the increase in OPG is a consequence or a causal factor of plaque destabilization deserves further investigation.

Limitations of OCT in identifying and quantifying lipid components: an in vivo comparison study with IVUS-NIRS

AIMS We aimed to assess the agreement between IVUS-NIRS and OCT to assess lipid plaques in patients with acute coronary syndromes or stable angina. In addition, the impact of both macrophages and calcifications was investigated. METHODS AND RESULTS Forty-three patients undergoing both IVUS-NIRS and OCT assessment of the culprit and/or non-culprit coronary lesions were enrolled. Cross-sections from lipid plaques, calcified plaques and normal-appearing vessel tracts were identified and matched with the two imaging techniques. Lipid arc was measured by both IVUS-NIRS and OCT. Macrophage presence and calcifications were also investigated with OCT. OCT detected a lipid plaque in 90 cross-sections (48.9%), with a sensitivity of 85.5% and a specificity of 69.7% as compared with IVUS-NIRS. The percentage of OCT false positive was 20.1% and of false negative was 4.9% for lipid plaque detection. The Pearson correlation coefficient for lipid arc was 0.675, p=0.0001. Macrophages were detected in 73% of OCT false positive cross-sections. Conversely, calcifications were present in 66.7% of OCT false negative cross-sections. The variability of lipid arc was independently associated with macrophages (beta=0.295, p=0.013). CONCLUSIONS Agreement between IVUS-NIRS and OCT for lipid plaque detection is suboptimal. The presence of macrophages and superficial calcifications on OCT negatively affects lipid detection.

Coronary-subclavian steal phenomenon late after coronary artery bypass grafting: an underappreciated cause of myocardial ischemia?

Coronary-subclavian steal (CSS) is an increasingly reported phenomenon after coronary artery bypass graft (CABG) operation and it is caused by proximal subclavian artery stenosis in patients with internal thoracic artery grafts. We discuss briefly the diagnostic strategies to rule out significant subclavian stenosis before CABG and, in the follow-up, the importance of subclinical detection of coronary-subclavian steal before the potential onset of myocardial ischemia. Although the most appropriate management of concomitant brachiocephalic and coronary artery disease remains a matter of debate, patients developing CSS syndrome after CABG can be treated successfully by both surgical and percutaneous techniques. Retrospective analysis of surgical databases will help to identify the predictors, if any, of subclavian artery disease progression in candidates for internal thoracic artery grafting, in order to choose a tailored surgical approach.

Recent Advances in Carotid Artery Stenting

Carotid artery stenting (CAS), which has emerged as an alternative therapy to high-risk surgical patients, has become an increasingly important procedure in the optimal management of patients with carotid disease. Current evidence both in symptomatic and in asymptomatic patients suggests that CAS should be performed by skilled operators with formal training and in high-volume centers with a standardized and tailored approach.

Right anterior mini-thoracotomy vs . conventional sternotomy for aortic valve replacement: a propensity-matched comparison

Background Right anterior mini-thoracotomy (MIAVR) is a promising technique for aortic valve replacement. We aimed at comparing its outcomes with those obtained in a propensity-matched group of patients undergoing sternotomy at our two high-volume centers. Methods Main clinical and operative data of patients undergoing aortic valve replacement between January 2010 and May 2016 were retrospectively collected. A total of 678 patients were treated with a standard full sternotomy approach, while MIAVR was performed in 502. Propensity score matching identified 363 patients per each group. Results In-hospital mortality was not significantly different between the propensity-matched groups (1.7% in MIAVR patients vs. 2.2% in conventional sternotomy patients; P=0.79). No significant difference in the incidence of major post-operative complications was observed. Post-operative ventilation times (median 7, range 5-12 hours in MIAVR patients vs. median 7, range 5-12 in conventional sternotomy patients; P=0.72) were not significantly different between the two groups. Cardiopulmonary bypass time (61.0±21.0 vs. 65.9±24.7 min in conventional sternotomy group; P<0.01) and aortic cross-clamping time (48.3±16.7 vs. 53.2±19.6 min in full sternotomy group; P<0.01) were shorter in MIAVR group. EuroSCORE (OR 1.52, 95% CI, 1.12-2.06; P<0.01) was found to be the only independent predictor of intra-hospital mortality in the whole propensity-matched population. Conclusions Our experience shows that mini-access isolated aortic valve surgery is a reproducible, safe and effective procedure with similar outcomes and no longer operative times compared to conventional sternotomy.

Contrast-Zero Transcatheter Aortic Valve Replacement for Patients With Severe Renal Dysfunction: A Single-Center Experience

Chronic kidney disease is a prognostically relevant predictor of periprocedural acute kidney injury after transcatheter aortic valve replacement (TAVR). [(1)][1]. In spite of being related to multiple possible causes (i.e., anemia, hypotension, heart failure, age, diabetes), the administration of

Gender Differences in CAS

Ischemic stroke is now the third most common cause of death in the Western world [1] (Fig. 18.1). In addition, the morbidity related to cerebrovascular disease is particularly disabling, because it causes neurological deficits leading to a loss of autonomy and disability in performing normal daily activities, due to enormous costs for the national health system and society [2]. The incidence of stroke was 0.2 % per year in the general population but rises significantly in the presence of multiple risk factors [3].

Impact of oral P2Y12 inhibitors on residual thrombus burden and reperfusion indexes in patients with ST-segment elevation myocardial infarction.

Aims We sought to assess the impact of different oral P2Y12 receptor inhibitors on residual thrombus and reperfusion indexes in ST-segment elevation myocardial infarction patients enrolled in the COCTAIL II trial, which included 128 primary percutaneous coronary interventions randomized to intracoronary vs. intralesion abciximab bolus with or without thrombectomy. Methods Patients were divided into three groups: clopidogrel (n = 44), prasugrel (n = 45) and ticagrelor (n = 39). Residual intra-stent thrombus was quantified by optical coherence tomography using both the number of cross-sections with thrombus area more than 10% and thrombus volume. Reperfusion indexes included thrombolysis in myocardial infarction (TIMI) flow, corrected TIMI frame count, myocardial blush grade (MBG) and complete ST-segment resolution (≥70%). Results In the prasugrel group, optical coherence tomography depicted a lower percentage of cross-sections with residual thrombus area more than 10% [4.0 (1.0–8.5)], as compared with clopidogrel [8.0 (1.0–15.0), P = 0.011] and ticagrelor [7.0 (3.0–13.5), P = 0.026].A higher thrombus volume was found in the clopidogrel group 4.0 mm3(2.7–6.2) as compared with the prasugrel group [2.8 mm3(1.8–4.4), P = 0.023], whereas the other between-group comparisons yield no significant differences. The frequency of MBG 3 was higher in the prasugrel group (73.3%) as compared with clopidogrel (45.5%) and ticagrelor [(56.4%), P = 0.027]. Final TIMI flow, TIMI frame count and ST resolution were not significantly different across the three groups (P = 0.423, 0.179 and 0.848, respectively). At multivariate analysis, pretreatment with prasugrel was independently associated with MBG 3 (odds ratio = 3.93; 95% confidence interval = 1.01–15.39). Conclusion Prasugrel loading dose was associated with a lower percentage of cross-sections with residual thrombus area more than 10% as compared with both clopidogrel and ticagrelor, although intrastent thrombus volume was not significantly different between prasugrel and ticagrelor. The frequency of MBG 3 was the only reperfusion index that was significantly more prevalent in prasugrel treated group as compared with clopidogrel and ticagrelor groups.