Anunaya Jain

Effect of anticoagulant and antiplatelet therapy in patients with spontaneous intra-cerebral hemorrhage: Does medication use predict worse outcome?

OBJECTIVES To assess the impact of anticoagulants and antiplatelet agents on the severity and outcome of spontaneous non-traumatic intra-cerebral hemorrhage (ICH). To evaluate associations between reversal of anticoagulation and mortality/morbidity in these patients. METHODS Data was collected on a consecutive cohort of adults presenting with ICH to an academic Emergency Department over a 3-year period starting January 2006. RESULTS The final cohort of 245 patients consisted of 125 females (51.1%). The median age of the cohort was 73 years [inter-quartile (IQR) range of 59-82 years]. Antiplatelet (AP) use was seen in 32.6%, 18.4% were using anticoagulant (AC) and 8.9% patients were on both drugs (AC+AP). Patients on AC had significantly higher INR (median 2.3) and aPTT (median 31 s) when compared to patients not on AP/AC (median INR 1.0, median aPTT 24s; p<0.001). Similarly patients on AC+AP also had higher INR (median 1.9) and aPTT (median 30s) when compared to those not on AC/AP (p<0.001). Hemorrhage volumes were significantly higher for patients on AC alone (median 64.7 cm(3)) when compared to those not on either AC/AP (median 27.2 cm(3); p=0.05). The same was not found for patients using AP (median volume 20.5 cm(3); p=0.813), or both AC+AP (median volume 27.7 cm(3); p=0.619). Patients on AC were 1.43 times higher at risk to have intra-ventricular extension of hemorrhage (IVE) as compared to patients not on AC/AP (95% CI 1.04-1.98; p=0.035). There was no relationship between the use of AC/AP/AC+AP and functional outcome of patients. Patients on AC were 1.74 times more likely to die within 7 days (95% CI 1.0-3.03; p=0.05). No relationship was found between use of AP or AC+AP use and mortality. Of the 82 patients with INR>1.0, 52 patients were given reversal (minimum INR 1.4, median 2.3). Therapy was heterogeneous, with fresh frozen plasma (FFP) being the most commonly used agent (86.5% patients, median dose 4U). Vitamin K, activated factor VIIa and platelets were the other agents used. Post reversal, INR normalized within 24h (median 1.2, IQR 1.1-1.3). There was no association between reversal and volume of hemorrhage, IVE, early mortality (death<7 days) or functional outcome. CONCLUSIONS Anticoagulated patients were at 1.7 times higher risk of early mortality after ICH. Reversal of INR to normal did not influence mortality or functional outcome.

Female Gender Remains an Independent Risk Factor for Poor Outcome after Acute Nontraumatic Intracerebral Hemorrhage

Objective. To study whether gender influences outcome after intracerebral hemorrhage (ICH). Methods. Cohort study of 245 consecutive adults presenting to the emergency department with spontaneous ICH from January 2006 to December 2008. Patients with subarachnoid hemorrhage, extradural hemorrhage, and recurrence of hemorrhage were excluded. Results. There were no differences noted between genders in stroke severity (NIHSS) at presentation, ICH volume, or intraventricular extension (IVE) of hemorrhage. Despite this, females had 1.94 times higher odds of having a bad outcome (modified Rankin score (mRs) ≥3) as compared to males (95% CI 1.12 to 3.3) and 1.84 times higher odds of early mortality (95% CI 1.02–3.33). analyzing known variables influencing mortality in ICH, the authors found that females did have higher serum glucose levels on arrival (P = 0.0096) and 4.2 times higher odds for a cerebellar involvement than males (95% CI 1.63–10.75). After adjusting for age, NIHSS, glucose levels, hemorrhage volume, and IVE, female gender remained an independent predictor of early mortality (P = 0.0127). Conclusions. Female gender may be an independent predictor of early mortality in ICH patients, even after adjustment for stroke severity, hemorrhage volume, IVE, serum glucose levels, and age.

Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke

Because hemorrhagic transformation affects treatment and patient prognosis, these authors explored whether CT perfusion predicts it. Twenty percent of their subjects developed hemorrhagic transformation and these patients did not differ from controls in terms of age, gender, time to presentation, or comorbidities. Only CBV was found to be lower and predictive of hemorrhagic transformation. BACKGROUND AND PURPOSE: Prediction of hemorrhagic transformation in acute ischemic stroke could help determine treatment and prognostication. With increasing numbers of patients with acute ischemic stroke undergoing multimodal CT imaging, we examined whether CT perfusion could predict hemorrhagic transformation in acute ischemic stroke. MATERIALS AND METHODS: Patients with acute ischemic stroke who underwent CTP scanning within 12 hours of symptom onset were examined. Patients with and without hemorrhagic transformation were defined as cases and controls, respectively, and were matched as to IV rtPA administration and presentation NIHSS score (± 2). Relative mean transit time, relative CBF, and relative CBV values were calculated from CTP maps and normalized to the contralateral side. Receiver operating characteristic analysis curves were created, and threshold values for significant CTP parameters were obtained to predict hemorrhagic transformation. RESULTS: Of 83 patients with acute ischemic stroke, 16 developed hemorrhagic transformation (19.28%). By matching, 38 controls were found for only 14 patients with hemorrhagic transformation. Among the matched patients with hemorrhagic transformation, 13 developed hemorrhagic infarction (6 hemorrhagic infarction 1 and 7 hemorrhagic infarction 2) and 1 developed parenchymal hematoma 2. There was no significant difference between cases and controls with respect to age, sex, time to presentation from symptom onset, and comorbidities. Cases had significantly lower median rCBV (8% lower) compared with controls (11% higher) (P = .009; odds ratio, 1.14 for a 0.1-U decrease in rCBV). There was no difference in median total volume of ischemia, rMTT, and rCBF among cases and controls. The area under the receiver operating characteristic was computed to be 0.83 (standard error, 0.08), with a cutoff point for rCBV of 1.09. CONCLUSIONS: Of the examined CTP parameters, only lower rCBV was found to be significantly associated with a relatively higher chance of hemorrhagic transformation.

Emergency care in India: the building blocks.

BackgroundThe Republic of India, the world’s most populous democracy, has struggled with establishing Emergency Medical Care. However, with the recent recognition of Emergency Medicine as a formal specialty in medical training, there has been renewed vigor in the developments in the field.Method and ResultsWe outline here the building blocks of the health care system in India, and the contribution each has made and is capable of making to the growth of emergency medical services. We also provide an account of the current situation of emergency medicine education in the country.ConclusionsAs we trace the development and status of emergency medicine in India, we offer insight into the current state of the field, what the future holds for the emergency medical community, and how we can get there.

Evidence-based treatment of carotid artery stenosis

Carotid atheromatous disease is an important cause of stroke. Carotid endarterectomy (CEA) is a well-established option for reducing the risk of subsequent stroke due to symptomatic stenosis (> 50%). With adequately low perioperative risk (< 3%) and sufficient life expectancy, CEA may be used for asymptomatic stenosis (> 60%). Recently, carotid angioplasty and stent placement (CAS) has emerged as an alternative revascularization technique. Trial design considerations are discussed in relation to trial results to provide an understanding of why some trials were considered positive whereas others were not. This review then addresses both the original randomized studies showing that CEA is superior to best medical management and the newer studies comparing the procedure to stent insertion in both symptomatic and asymptomatic populations. Additionally, recent population-based studies show that improvements in best medical management may be lowering the stroke risk for asymptomatic stenosis. Finally, the choice of revascularization technique is discussed with respect to symptom status. Based on current evidence, CAS should remain limited to specific indications.

Emergency department over-crowding: a global perspective

Emergency department (ED) over-crowding has been a topic of intense interest over the past few years, with the Institute of Medicine report “Emergency Care at a Crossroads” published in 2006 [1], followed by the American College of Emergency Physicians task force report on boarding (2008) and, most recently, the United States Government Accountability Office (GAO) Report to the Chairman [2], Committee on Finance, U.S. Senate published in April 2009. Similarly, the Canadian Association of Emergency Physicians and the Australasian College for Emergency Medicine have also recognized the primary problem of over-crowding in the ED [3, 4]. The adverse effects of the global problem of ED over-crowding are well known. Crowding negatively impacts all stakeholders: patients, physicians, and the hospital. Most important is patient safety, with decreased quality of care and an increase in medical errors in overcrowded EDs. Further, patients have a poor experience, which leads them to leave without being seen, and they are less likely to return to the ED in the future. Physicians and other providers experience decreased job satisfaction, resulting in decreased productivity and increased staff turnover. For the hospital, ED over-crowding results in lost revenue from multiple sources. Revenue is lost from patients who leave without being seen, from emergency medical service (EMS) diversion secondary to dissatisfaction among both patients and EMS crews, and from shifting of the market share to competitors. Consider the real mortality risk associated with ED over-crowding. A study of over 55,000 ED patients demonstrated a higher mortality rate among patients boarded in the ED than in those moved to an inpatient hallway bed (p < 0.05). Furthermore, the Joint Commission on the Accreditation of Healthcare Organizations (JCAHO) notes that 50% of sentinel events occur in the ED and of these one third are due to over-crowding. Hospitals and EDs react in a crisis. Institutions, stressed by overcrowding, often engage in short-term fixes which do not address the underlying issues, and ultimately only exacerbate the problem. For example, increased staffing and expansion of the ED do not necessarily produce gains. Rather, redesigning for optimization of the system by which patients are processed is the key. The secret to success is not to allocate more, but to strategically re-allocate resources. In 2001, a survey of 575 ED directors reported overcrowding in 94% of academic EDs and 91% of private hospital EDs [5]. In this time of economic downturn, the issue of ED over-crowding becomes even more poignant as a global issue. This issue of International Journal of Emergency Medicine features two studies that highlight the problem of ED over-crowding. In their 7-year longitudinal study, Graham et al. [6] report on the trends in Prince of Wales Hospital, a busy (>155,000 patient visits per year) tertiary referral facility with 1,400 beds which serves as the primary teaching hospital of the Chinese University of Hong Kong. The authors note that while the SARS epidemic and the introduction of co-pay in the ED resulted in an overall net decrease of ED volumes, the concurrent increase in patients brought in via ambulance plus reduction of medical and nursing staff resulted in increased waiting times. The over-crowding problem is compounded by the marked increase in the medical admission rate, which correlates with the 12% increase in the geriatric population visits. The second study, by Kulstad and Kelley [7], entitled “Over-crowding is associated with delays in percutaneous coronary intervention for acute myocardial infarction” uses the EDWIN score as a marker of ED over-crowding and its association with ultimate delays in patients receiving percutaneous intervention for acute myocardial infarction. The EDWIN score is the sum of the number of patients in the ED multiplied by their acuity, divided by the number of attending physicians working in the ED, multiplied by the number of inpatient boarders. The authors report a decreased likelihood of timely treatment for acute MI during times of over-crowding in their emergency department. These studies underscore the very real and detrimental effects of ED over-crowding. The most important root cause of ED over-crowding is the inability to transfer emergency patients to inpatient beds and the resultant boarding of admitted patients in the ED. Solutions to decrease boarding in the ED include moving boarders into inpatient hallways at the front end, and increasing the rate of discharges by noon at the back end. Movement of patients to inpatient hallways, while known to be safer for patients, still often results in push-back from the inpatient services. One commonly cited reason is patient dissatisfaction. As the science of ED over-crowding evolves, studies addressing this very issue have also been performed. A study of 445 patients reports an overall preference of 87% for inpatient hallway beds. Reasons cited for this preference included better privacy, staff availability, safety, rest, quiet, and treatment [8]. Movement of patients to hallway beds and boosting discharges before noon are sometimes thought of as the “external factor,” as they involve practice outside of the ED, namely inpatient floors. There are of course a number of measures that can be undertaken to increase throughput in the ED that can be considered “internal factors.” These include streamlined and simplified triage, point-of-care laboratory testing for diagnostics that are a bottleneck to the next step, and care pathways, to name a few. The first step of solving any problem, acknowledging it, is well past. We know that patient volumes of EDs are going to increase at an exponential rate, as suggested by the CDC in 2005 [9], Our objectives should be to enable efficient care to everyone at all times. We have potential allies in technology, streamlined business management strategies, including Lean for process evolution and Six Sigma, and collaborative alliances between hospitals to develop creative solutions to the problem of ED over-crowding. In today’s evolving healthcare scenario, EDs are not only a point of care for the acutely ill, but also have a role as a safety net to provide healthcare to people regardless of their insurance status or ability to pay, as dictated by laws like the Emergency Medical Treatment and Labor Act (EMTALA) in the US. It is of paramount importance that a serious and unified approach to ED over-crowding be taken, at all levels. This would represent a major step towards establishing a culture of patient safety and satisfaction in the ED.

Does Prolonged Length of Stay in the Emergency Department Affect Outcome for Stroke Patients

Introduction: Conflicting data exist regarding the association between the length of stay (LOS) of critically ill patients in the emergency department (ED) and their subsequent outcome. However, such patients are an overall heterogeneous group, and we therefore sought to study the association between EDLOS and outcomes in a specific subgroup of critically ill patients, namely those with acute ischemic stroke/transient ischemic attack (AIS/TIA). Methods: This was a retrospective review of adult patients with a discharge diagnosis of AIS/TIA presenting to an ED between July 2009 and February 2010. We collected demographics, EDLOS, arrival stroke severity (National Institutes of Health Stroke Scale - NIHSS), intravenous tissue plasminogen activator (IV tPA) use, functional outcome at discharge, discharge destination and hospital-LOS. We analyzed relationship between EDLOS, outcomes and discharge destination after controlling for confounders. Results: 190 patients were included in the cohort. Median EDLOS was 332 minutes (Inter-Quartile Range -IQR: 250.3–557.8). There was a significant inverse linear association between EDLOS and hospital-LOS (p=0.049). Patients who received IV tPA had a shorter median EDLOS (238 minutes, IQR: 194–299) than patients who did not (median: 387 minutes, IQR: 285–588 minutes; p<0.0001). There was no significant association between EDLOS and poor outcome (p=0.40), discharge destination (p=0.20), or death (p=0.44). This remained true even after controlling for IV tPA use, NIHSS and hospital-LOS; and did not change even when analysis was restricted to AIS patients alone. Conclusion: There was no significant association between prolonged EDLOS and outcome for AIS/TIA patients at our institution. We therefore suggest that EDLOS alone is an insufficient indicator of stroke care in the ED, and that the ED can provide appropriate acute care for AIS/TIA patients. [West J Emerg Med. 2014;15(3):267–275.]

The Triglyceride Paradox in Stroke Survivors: A Prospective Study

Objective. The purpose of our study was to understand the association between serum triglycerides and outcomes in acute ischemic stroke (AIS) patients. Methods. A cohort of all adult patients presenting to the Emergency Department (ED) with an AIS from March 2004 to December 2005 were selected. The lipid profile levels were measured within 24 hours of stroke onset. Demographics, admission stroke severity (NIHSS), functional outcome at discharge (modified Rankin Scale (mRS)), and mortality at 3 months were recorded. Results. The final cohort consisted of 334 subjects. A lower level of triglycerides at presentation was found to be significantly associated with worse National Institutes of Health Stroke Scale (NIHSS) (P = 0.004), worse mRS (P = 0.02), and death at 3 months (P = 0.0035). After adjusting for age and gender and NIHSS, the association between triglyceride and mortality at 3 months was not significant (P = 0.26). Conclusion. Lower triglyceride levels seem to be associated with a worse prognosis in AIS.