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Anupam Gohel

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Publication

Featured researches published by Anupam Gohel.

Angewandte Chemie | 2018

Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction

Feng Xu; Birgit Kosjek; Fabien Louis Cabirol; Haibin Chen; Richard Desmond; Jeonghan Park; Anupam Gohel; Steven J. Collier; Derek Smith; Zhuqing Liu; Jacob M. Janey; John Y. L. Chung; Oscar Alvizo

Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high-pH environment. To overcome enzyme performance limitations under these conditions, a ketoreductase was evolved by a computationally and structurally aided strategy to increase cofactor stability through tighter binding.

Organic Process Research & Development | 2014

Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase

Naga K. Modukuru; Joly Sukumaran; Steven J. Collier; Ann Shu Chan; Anupam Gohel; Gjalt Huisman; Raquel Keledjian; Karthik Narayanaswamy; Scott Novick; S. M. Palanivel; Derek Smith; Zhang Wei; Brian Wong; Wan Lin Yeo; David A. Entwistle

Archive | 2011

Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol

Fabien Louis Cabirol; Anupam Gohel; Seong Ho Oh; Derek Smith; Brian Wong; James Lalonde

Archive | 2012

Biocatalysts for the preparation of hydroxy substituted carbamates

Fabien Louis Cabirol; Haibin Chen; Anupam Gohel; Steven J. Collier; Derek Smith; Birgit Kosjek; Jacob Janey

Archive | 2013

BIOCATALYSTS AND METHODS FOR HYDROXYLATION OF CHEMICAL COMPOUNDS

Haibin Chen; Yong Koy Bong; Fabien Louis Cabirol; Anupam Gohel; Tao Li; Jeffrey C. Moore; Martina Quintanar-Audelo; Hong Yang; Steven J. Collier; Derek Smith

Archive | 2011

Biocatalysts for ezetimibe synthesis

Michael A. Crowe; Oscar Alvizo; Behnaz Behrouzian; Yong Koy Bong; Steven J. Collier; Anupam Gohel; Jagadeesh Mavinahalli; Naga K. Modukuru; Emily Mundorff; Derek Smith; Shiwei Song; Wan Lin Yeo

Archive | 2011

Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine

John Limanto; Gregory Beutner; Brendan Grau; Jacob Janey; Artis Klapars; Eric R. Ashley; Hallena R. Strotman; Matthew D. Truppo; Gregory Hughes; Fabien Louis Cabirol; Anupam Gohel; Steven J. Collier; Jack Liang; Marissa Mock; Emily Mundorff; Scott Novick; Derek Smith

Archive | 2013

Fungal beta-xylosidase variants

Ryan Fong; Xiyun Zhang; Chris Noriega; Nicholas J. Agard; Anupam Gohel; Derek Smith

Archive | 2012

Biocatalysts and methods for the synthesis of substituted lactams

Fabien Louis Cabirol; Haibin Chen; Anupam Gohel; Paulina Salim; Derek Smith; Jacob Janey; Birgit Kosjek; Weng Lin Tang; Helen Hsieh; Son Pham

Archive | 2012

BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF

Anupam Gohel; Derek Smith; Brian Wong; Joly Sukumaran; Wan Lin Yeo; Steven J. Collier; Scott Novick

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Derek Smith

Codexis

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Fabien Louis Cabirol

Codexis

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Steven J. Collier

University of Liverpool

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Scott Novick

Codexis

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Brian Wong

Codexis

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Emily Mundorff

Codexis

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Jacob Janey

University of Chicago

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Steven J. Collier

University of Liverpool

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Haibin Chen

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Wan Lin Yeo

Agency for Science

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