Aqib Zahoor
University of Karachi
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Publication
Featured researches published by Aqib Zahoor.
Journal of Natural Products | 2011
Imran Nafees Siddiqui; Aqib Zahoor; Hidayat Hussain; Ishtiaq Ahmed; Viqar Uddin Ahmad; Daniele Padula; Siegfried Draeger; Barbara Schulz; Kathrin Meier; Michael Steinert; Tibor Kurtán; Ulrich Flörke; Gennaro Pescitelli; Karsten Krohn
Chemical investigation of the fungal strain Microdiplodia sp. isolated from the shrub Lycium intricatum led to the isolation of four new compounds: a hexahydroxanthone (2), a 2,3-dihydrochroman-4-one (3), a 7-oxoxanthone derivative (4), and a 1,4-oxazepan-7-one (5). The relative configurations of the new compounds were determined by intensive NMR investigations, notably NOESY experiments at different temperatures. The absolute configurations of the well-known fungal metabolite diversonol (1) and of other xanthone derivatives (3, 4) were established by means of TDDFT ECD calculations. Most of the metabolites were biologically active, with antibacterial activity against Legionella pneumophila and/or antifungal activity against Microbotryum violaceum.
Phytomedicine | 2014
Saleha Suleman Khan; Ajmal Khan; Afsar Khan; Abdul Wadood; Umar Farooq; Amir Ahmed; Aqib Zahoor; Viqar Uddin Ahmad; Bilge Sener; Nurgun Erdemoglu
Five ursane type sulfated saponins have been isolated from the aerial parts of Zygophyllum fabago Linn. (locally called Chashum). The urease inhibitory effects of these compounds have been investigated for the first time as well as their molecular docking studies have also been carried out to check the structure-activity relationship. The IC50 values of these compounds could not be found due to paucity of the samples. The molecular docking studies were performed only for the most active compound mono sodium salt of 3β,23-di-O-sulfonyl-23-hydroxyurs-20(21)-en-28-oic acid 28-O-[β-D-glucopyranosyl] ester (Zygofaboside A; 1).
Jpc-journal of Planar Chromatography-modern Tlc | 2015
Sadia Shakeel; Somia Gul; Aqib Zahoor; Saleha Suleman Khan; Zeeshan Ahmed Sheikh; Safila Naveed; Khan Usmanghani
The technological improvement in the structural elucidation of natural compounds has made it probable to generate appropriate strategies for the analysis and standardization of plant-based medicines. An appliance of highly oriented hyphenated techniques provides a definite tool for herbal investigations. Therefore, the present study was directed towards the standardization of biomarkers gallic acid and berberine in polyherbal formulation Entoban capsules to ensure the quality of the herbal drugs. A rapid, simple, accurate, and specific high-performance thin-layer chromatography (HPTLC) method for the quantitative estimation of biomarkers berberine and gallic acid has been developed. HPTLC was performed to evaluate the presence of gallic acid and berberine applying toulene—ethyl acetate—formic acid—methanol (12:9:4:0.5 v/v) and ethanol—water—formic acid (90:9:1 v/v), as the mobile phase, respectively. The RF values (0.58 for gallic acid and 0.76 for berberine) in both sample and reference standard were found comparable under ultraviolet (UV) light at 273 nm and 366 nm, respectively. The method developed resulted in good-quality peak shape and enabled high-quality resolution of biomarkers. The present standardization undertaken reveals compliance with the analytical procedure; therefore, it is concluded that Entoban capsule is a well-standardized product. Standardization falls under the specific guidelines of quality herbal medicine following the prerequisite for global harmonization.
American Journal of Advanced Drug Delivery | 2017
Hina Rehman; Aqib Zahoor; Zeeshan Ahmed Shaikh; Safila Naveed; Khan Usmanghani
Objective: The development of modern dosage form such as lozenges associated with an extended period of local remedy with beneficial therapeutic effect was the objective of this study. The polyherbal extract based lozenges include Viola odorata L, Cordialatifolia L, Menthapiperita L., Adhatodavasica, Glycyrrhizaglabra, Piper longum, Hyssopusofficinalis, Alpiniagalangal which is envisioned for cough and sore throat. Method The preparation of extract, manufacturing of lozenges batch, processing technique with extract based herbal formulation and expansion for analytical standardization including qualitative and quantitative determinations were carried out. Result Vasicine was analysed qualitative and quantified through HPTLC and quantitative analysis of flavonoids by UV visible spectrophotometry, which was not less than 0.02 mg per lozenges and 0.080 mg respectively. Conclusion Current trend of herbal market and the visible financial growth with evident therapeutic graph has proven its effectiveness. Minimum side effects make the herbal and alternative medication more attractive for the end users. This poly herbal extract based lozenges have proven the quality by both protocols including qualitatively via organoleptic attributes and quantitatively by HPTLC and spectrophotometry.
Journal of Asian Natural Products Research | 2015
Hidayat Hussain; Karsten Krohn; Ahmed Al-Harrasi; Simeon F. Kouam; Gulam Abbas; Muhammad Adil Raees; Thomas Dzeha; Riaz Ullah; Aqib Zahoor; Afzal Shah; Amin Badshah; Amjad Khan; Iftikhar Ali; Barbara Schulz
Phytochemical investigation of the endophytic fungus Microdiplodia sp. afforded a new m-anisaldehyde derivative named microdiplanol (1) and a new 24-methylcholestanol derivative named microdiplane (2). Their structures were confirmed by a comprehensive analysis of 1D and 2D NMR and mass spectrometric data.
Natural Product Communications | 2010
Zahid Hassan; Viqar Uddin Ahmad; Javid Hussain; Aqib Zahoor; Imran Nafees Siddiqui; Nasir Rasool; Muhammad Zubair
Natural Product Communications | 2010
Imran Nafees Siddiqui; Viqar Uddin Ahmad; Aqib Zahoor; Amir Ahmed; Siraj Khan; Afsar Khan; Zahid Hassan
Natural Product Communications | 2010
Aqib Zahoor; Imran Nafees Siddiqui; Afsar Khan; Viqar Uddin Ahmad; Amir Ahmed; Zahid Hassan; Siraj Khan; Shazia Iqbal
Archive | 2012
Aqib Zahoor; Hidayat Hussain; Afsar Khan; Ishtiaq Ahmed; Viqar Uddin Ahmad; Karsten Krohn
Asian pacific Journal of Tropical Biomedicine | 2015
Zeeshan Ahmed Sheikh; Sadia Shakeel; Somia Gul; Aqib Zahoor; Saleha Suleman Khan; Faisal Haider Zaidi; Khan Usmanghani