Ario Federici

Effectiveness of professionally-guided physical education on fitness outcomes of primary school children.

Abstract Physical education (PE) at school is an important starting point for long-term interventions improving quality of life in elderly. To evaluate the effectiveness of professionally led PE on motor and health-related abilities of Italian primary schoolchildren (3rd–5th graders), three schools were assigned to the experimental groups “A” (38 pupils, 17 M, 21 F) and “B” (37 pupils, 16 M, 21 F), and to control group “C” (26 pupils, 18 M, 8 F). All groups underwent a six-month, twice-a-week (60 min each session) PE intervention. The PE program of the EGs was age-tailored, included strength training and was administered by specialised teachers. Group A and B programs differed in the strength training devices used, while they were identical in terms of training load. The control group program was not structured and administered by generalist teachers. At baseline and follow-up, children underwent a motor and health-related abilities test battery. At follow-up, children in group C gained significantly more weight than children in the EGs and scored significantly less than the children in the EGs in the following assessments: counter movement jump (C:+0.15% vs. A:+4.1% and B:+6.99%), plate tapping (C:+13.56% vs. A:+19.37% and B:+36.12%), sit-and-reach (C:−311.15% vs. B:+409.57%), pinch strength (C:+2.39% vs. B:+10.83, on average) and sit-up (C:+29.69% vs. A:+72.61%). In conclusion, specialist-led pupils demonstrated greater increases in some motor and health-related abilities tests compared to generalist-led peers, while different strength training devices produced comparable increases of strength in both EGs.

Trunk muscles activation during pole walking vs. walking performed at different speeds and grades.

Given their functional role and importance, the activity of several trunk muscles was assessed (via surface electromyography-EMG) during Walking (W) and Pole Walking (PW) in 21 healthy adults. EMG data was collected from the external oblique (EO), the erector spinae longissimus (ES), the multifidus (MU), and the rectus abdominis (RA) while performing W and PW on a motorized treadmill at different speeds (60, 80, and 100% of the highest speed at which the participants still walked naturally; PTS60, PTS80 and PTS100, respectively) and grades (0 and 7%; GRADE0 and GRADE7, respectively). Stride length, EMG area under the curve (AUC), muscles activity duration (ACT), and percentage of coactivation (CO-ACT) of ES, MU and RA, were calculated from the averaged stride for each of the tested combinations. Compared to W, PW significantly increased the stride length, EOAUC, RAAUC and the activation time of all the investigated muscles, to different extents depending on treadmill speeds and grades. In addition, MUAUC was higher in PW than in W at GRADE0 only (all speeds, p<0.01), while ESAUC during W and PW was similar at all the speeds and grades. These changes resulted in longer CO-ACT in PW than W, at GRADE0-PTS100 (p<0.01) and GRADE7 (all speeds, p<0.01). In conclusion, when compared to W, PW requires a greater engagement of the abdominal muscles and, in turn, a higher control of the trunk muscles. These two factors taken together may suggest an elevated spinal stability while walking with poles.

High Cardiorespiratory Fitness Is Negatively Associated with Daily Cortisol Output in Healthy Aging Men

Physical fitness has salutary psychological and physical effects in older adults by promoting neuroplasticity and adaptation to stress. In aging, however, the effects of fitness on the hypothalamic-pituitary-adrenal (HPA) axis are mixed. We investigated the association between cardiorespiratory fitness and HPA activity in healthy elderly men (n = 22, mean age 68 y; smokers, obese subjects, those taking drugs or reporting recent stressful events were excluded), by measuring in saliva: i) daily pattern of cortisol secretion (6 samples: 30’ post-awakening, and at 12.00, 15.00, 18.00, 21.00, 24.00 h); and ii) the cortisol response to a mental challenge. Cardiorespiratory fitness (VO2max) was estimated using the Rockport Walking Test and the participants were assigned to high-fit (HF, ≥60°, n = 10) and low-fit (LF, ≤35°, n = 12) groups according to age-specific percentiles of VO2max distribution in the general population. At all daytimes, basal cortisol levels were lower in the HF than the LF group, most notably in the evening and midnight samples, with a significant main effect of physical fitness for cortisol levels overall; the area-under-the-curve for total daily cortisol output was significantly smaller in the HF group. Among the subjects who responded to mental stress (baseline-to-peak increment >1.5 nmol/L; n = 13, 5 LF, 8 HF), the amplitude of cortisol response and the steepness of recovery decline displayed an increasing trend in the HF subjects, although between-group differences failed to reach the threshold for significance. In conclusion, cardiorespiratory fitness in healthy aging men is negatively correlated with daily cortisol output and contributes to buffering the HPA dysregulation that occurs with advancing age, thus possibly playing a beneficial role in contrasting age-related cognitive and physical decline.

New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 and is characterized by its aggressive nature, lack of targets for targeted therapies, and early peak of recurrence. Due to these specific characteristics, chemotherapy does not usually yield substantial improvements and new target therapies and alternative strategies are needed. The beneficial responses of TNBC survivors to regular exercise, including a reduction in the rate of tumor growth, are becoming increasingly apparent. Physiological adaptations to exercise occur in skeletal muscle but have an impact on the entire body through systemic control of energy homeostasis and metabolism, which in turn influence the TNBC tumor microenvironment. Gaining insights into the causal mechanisms of the therapeutic cancer control properties of regular exercise is important to improve the prescription and implementation of exercise and training in TNBC survivors. Here, we provide new evidence of the effects of exercise on TNBC prevention, control, and outcomes, based on the inhibition of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB also known as Akt)/mammalian target of rapamycin (mTOR) (PI3K-Akt-mTOR) signaling. These findings have wide-ranging clinical implications for cancer treatment, including recurrence and case management.

Patterns of trunk muscle activation during walking and pole walking using statistical non-parametric mapping

This study used surface electromyography (EMG) to investigate the regions and patterns of activity of the external oblique (EO), erector spinae longissimus (ES), multifidus (MU) and rectus abdominis (RA) muscles during walking (W) and pole walking (PW) performed at different speeds and grades. Eighteen healthy adults undertook W and PW on a motorized treadmill at 60% and 100% of their walk-to-run preferred transition speed at 0% and 7% treadmill grade. The Teager-Kaiser energy operator was employed to improve the muscle activity detection and statistical non-parametric mapping based on paired t-tests was used to highlight statistical differences in the EMG patterns corresponding to different trials. The activation amplitude of all trunk muscles increased at high speed, while no differences were recorded at 7% treadmill grade. ES and MU appeared to support the upper body at the heel-strike during both W and PW, with the latter resulting in elevated recruitment of EO and RA as required to control for the longer stride and the push of the pole. Accordingly, the greater activity of the abdominal muscles and the comparable intervention of the spine extensors supports the use of poles by walkers seeking higher engagement of the lower trunk region.

Local stability and kinematic variability in walking and pole walking at different speeds

This study investigated the kinematic variability and the local stability of walking and pole walking using two tri-axial accelerometers placed on the seventh cervical (C7) and the second sacral (S2) vertebrae of twenty-one adults. Each participant performed three 1-min trials of walking and pole walking on a motorized treadmill (60, 80, 100% of the preferred walk-to-run transition speed). Forty strides per trial were used to calculate, in all directions of C7 and S2, the median of the stride-to-stride median absolute deviation (medMAD) and the local divergence exponent (λ). Generalised estimating equations and pairwise contrasts revealed, during pole walking, a higher medMAD (all directions, most speeds, C7 level only), and a lower λ (all directions, all speeds, both C7 and S2 level). As speed increased, so did medMAD (all directions, both walking with or without poles), with higher values at C7 compared to S2 level. A similar effect was observed for λ in the vertical direction (walking and pole walking), and in the anterior-posterior direction (only pole walking). An increase in speed brought about a λ reduction in the medial-lateral direction (C7 level only), especially during walking. Finally, both medMAD and λ were higher at C7 than S2 level (all directions, both walking and pole walking) except for λ in the anterior-posterior direction, which resulted higher in walking (C7 level only). In conclusion, despite a higher kinematic variability, pole walking appears to be more locally stable than walking at any speed, especially at C7 level.