Armand E. Brodeur

The role of gastrointestinal absorption of kerosene in producing pneumonitis in dogs

Kerosene was injected directly into the stomachs of pups which had previously had transections of their esophagi. The pups were examined radiographically and histologically (post mortem) for evidence of pneumonitis. None of the pups had any radiologic evidence of pneumonitis. Histologic examination after death revealed a suggestion of edema in 5 of the 7 dogs given kerosene. One had a focal hemorrhage; one, the pup which received the largest dose of kerosene, was normal histologically.

The danger of hydrogen peroxide as a colonic irrigating solution

Summary Laboratory studies on dogs confirm the clinical impression that major oxygen embolization, with temporary portal venous obstruction, may occur after irrigating the colon with 1 per cent hydrogen peroxide. Bacteremia occurred in a newborn following colonic irrigation with hydrogen peroxide. This problem warrants further definition. A previously unindicted therapeutic agent has been shown to have definite hazards. The prudence of its continued use is questioned.

Congenital peritoneal mesothelioma

Only three primary peritoneal mesotheliomas in children have been previously reported. We describe a 6-wk-old girl with a papillary peritoneal mesothelioma of low grade malignancy. This is probably a congenital mesothelioma and is the youngest patient reported to date.

Rectal mucosa stripping with abdominoperineal pull-through procedure: An anatomic and physiologic study

Abstract The use of the seromuscular cuff of the rectum, denuded of submucosa and mucosa, as a conduit for abdominoperineal pull-through procedure has merit. The procedure is not technically difficult. Postoperative complications are minimized by careful dissection, adequate hemostasis, and appropriate postoperative drainage. The technical problems of pelvic dissection and its complications are avoided. The results of this procedure are excellent, as judged by clinical observation and functional studies, up to 2 years following surgery. Microscopically there is significant muscular atrophy and fibrosis in the muscular cuff and in the wall of the colon within the cuff. Frequently definite evidence of a double muscular wall is lacking in the distal portion of the pull through. The significance of these changes cannot be determined by this study. There was no correlation between the histologic abnormalities and functional behavior which was observed over a 2-year period. More detailed anatomic studies and a longer period of followup should clarify this apparent contradiction.