Arram Ganesh
Osmania University
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Publication
Featured researches published by Arram Ganesh.
Medicinal Chemistry Research | 2015
D. Ashok; B. Vijaya Lakshmi; S. Ravi; Arram Ganesh
Chromene and coumarin scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing both, substituted 4-chloro-8-methyl-2-phenyl-1,5-dioxa-2H-phenanthren-6-ones, 3a–o have been synthesized from substituted (E)-1-(7-Hydroxy-4-methyl-8-coumarinyl)-3-phenyl-2-propen-1-ones, 2a–o in good yield using the microwave-assisted Vilsmeier–Haack reaction. All the synthesized compounds were tested in vitro for their antimicrobial activity. The compounds 3e, 3f and 3g were found to be potent against tested fungal and bacterial strains.
Chemistry of Heterocyclic Compounds | 2015
D. Ashok; Bommidi Vijaya Lakshmi; S. Ravi; Arram Ganesh; Shaik Adam
A series of new pyranochromenes has been synthesized by conventional and microwave irradiation methods from 10-chloro-4-methyl-2-oxo-8-phenyl-2,8-dihydropyrano[2,3-f]chromene-9-carbaldehyde using the Suzuki coupling. All the synthesized compounds were characterized by standard spectroscopic methods and elemental analysis and screened for their antibacterial and antifungal activities.
Russian Journal of General Chemistry | 2014
D. Ashok; Arram Ganesh; B. Vijaya Lakshmi; S. Ravi
Series of new (E)-1-aryl-3-[2-(piperidin-1-yl)quinolin-3-yl]prop-2-en-1-ones and (E)-1-aryl-3-[2-(pyrrolidin-1-yl)quinolin-3-yl]prop-2-en-1-ones have been efficiently prepared via the Claisen-Schmidt condensation of 2-(piperidin-1-yl)quinoline-3-carbaldehyde and 2-(pyrrolidin-1-yl)quinoline-3-carbaldehyde, respectively, with aryl methyl ketones under conditions of ultrasound and microwave irradiation. Structures of the products have been confirmed by IR, 1H NMR, 13C NMR, and mass spectroscopy, as well as by elemental analysis. Evaluation of the in vitro antibacterial activity against bacterial (Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli) and fungal (Aspergillus niger and Candida metapsilosis) strains has revealed good antimicrobial activity of some of the tested compounds.
Medicinal Chemistry Research | 2016
D. Ashok; S. Ravi; Arram Ganesh; B. Vijaya Lakshmi; Shaik Adam; S. D. S. Murthy
A new class of chalcones, aurones and flavones derived from carbazole is designed as potential antimicrobial and antioxidant agents. Synthesis of (Z)-2-((9-ethyl-9H-carbazol-3-yl)methylene)benzofuran-3(2H)-ones and 2-(9-ethyl-9H-carbazol-3-yl)-4H-chromen-4-ones was carried out by the oxidation of (E)-3-(9-ethyl-9H-carbazol-3-yl)-1-(2-hydroxyphenyl)prop-2-en-1-ones under microwave irradiation and conventional heating. All the newly synthesized compounds were characterized on the basis of IR, 1H NMR, 13C NMR, mass and analytical data. All the synthesized compounds were evaluated for their antibacterial, antifungal and antioxidant activities. Synthesized compounds were screened in vitro for antibacterial activity against two gram-positive bacterial strains like Staphylococcus aureus and Bacillus subtilis and two gram-negative bacterial strains like Escherichia coli and Klebsiella pneumonia and antifungal activity by inhibitory action against three fungal strains like Fusarium oxysporum, Aspergillus niger and Aspergillus flavus. The synthesized compounds were also evaluated for their DPPH radical scavenging activity. All the newly synthesized compounds have shown good antibacterial, antifungal and antioxidant activities.
Russian Journal of General Chemistry | 2014
D. Ashok; Ravi Sidda; B. Vijaya Lakshmi; Arram Ganesh
We report the solvent-free synthesis of (E)-1-{3-[2-(9-Ethyl-9H-carbazol-3-yl)vinyl]benzofuran-2-yl}-2,2-dimethylpropan-1-ones starting with 9-Ethyl-9H-carbazole-3-carbaldehyde under conventional and microwave irradiation methods. All products were characterised by IR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The compounds were tested in vitro for their antimicrobial activity.
Russian Journal of Bioorganic Chemistry | 2016
D. Ashok; S. Ravi; B. Vijaya Lakshmi; Arram Ganesh; Shaik Adam
A novel series of 1,2,3-triazolo-carbazole chalcones were synthesized by the Claisen-Schmidt condensation reaction followed by the copper catalyzed Huisgen (2 + 3) cycloaddition reaction by conventional as well as microwave irradiation methods. The structures of the newly synthesized compounds were established on the basis of IR, 1H NMR, 13C NMR, and mass spectral data. All the compounds were screened in vitro for antibacterial and antifungal activities.
Russian Journal of General Chemistry | 2015
D. Ashok; Arram Ganesh; B. Vijaya Lakshmi; S. Ravi
A novel series of 2-(2-ethoxyindol-3-ylidene)-1-arylethanones and 2-(5-bromo-2-ethoxyindol-3-ylidene)-1-arylethanones were synthesized from 1H-indole-2,3-dione or 5-bromo-1H-indole-2,3-dione, arylmethylketone and ethyl alcohol in the presence of sulphuric acid (conc.) under microwave and ultrasound irradiation. All newly synthesized compounds were characterized by elemental analysis and spectral methods: IR, 1H and 13C NMR, mass spectra. Evaluation of the in vitro antibacterial activity against bacterial (Grampositive Staphylococcus aureus and Gram-negative Escherichia coli) and fungal (Aspergillus niger and Candida metapsilosis) strains revealed high antimicrobial activity of some tested compounds.
Russian Journal of General Chemistry | 2014
D. Ashok; B. Vijaya Lakshmi; Arram Ganesh; S. Ravi; Shaik Adam; S. D. S. Murthy
A series of new coumarin-chromene hybrids have been synthesized by conventional and microwave irradiation methods from 8-aryl-4-methyl-8,9-dihydropyrano[2,3-f]chromene-2,10-diones using the Vilsmeier-Haack reagent. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, MS, and elemental analyses and were screened for antibacterial and antifungal activity. Among the compounds tested, methoxy-substituted pyranochromenones revealed the best antimicrobial profile.
Russian Journal of General Chemistry | 2014
D. Ashok; Arram Ganesh; S. Ravi; B. Vijaya Lakshmi; B. Ramesh
One pot multicomponent synthesis of 3′,5-Diaryl-1′-phenyl-3,4-dihydro-1′H,2H-3,4′-bipyrazoles from 1-(1-methoxynaphthalen-2-yl)ethanone/1-(2-methoxynaphthalen-1-yl)ethanone, 3-aryl-1-phenyl-1Hpyrazole-4-carbaldehyde and hydrazines in the presence of basic alumina under conventional heating, ultrasound and microwave irradiation methods is presented. All newly synthesized compounds were evaluated for their in vitro antibacterial activity against bacterial strains Gram-positive (Staphylococcus aureus), Gramnegative (Escherichia coli) and strains (Aspergillus niger and Candida metapsilosis). The results of antibacterial and antifungal studies revealed that all compounds exhibited good antimicrobial activity. All synthesized analogues were characterized by IR, 1H and 13C NMR, and mass spectral data and elemental analysis.
Journal of The Serbian Chemical Society | 2015
D. Ashok; S. Ravi; Bommidi Vijaya Lakshmi; Arram Ganesh