Artur P. Herman
Silesian University of Technology
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Publication
Featured researches published by Artur P. Herman.
Journal of Materials Chemistry | 2012
Sławomir Boncel; Artur P. Herman; Krzysztof Walczak
Magnetic carbon nanostructures are hybrid materials containing magnetic and carbon (mainly sp2) nanoallotrope components conjugated in various configurations. Their potential applications in medicine including drug delivery systems, magnetic particle/fluid hyperthermia anti-cancer therapy and magnetic resonance imaging are reviewed.
Bioelectrochemistry | 2016
Katarzyna Krukiewicz; Patrycja Zawisza; Artur P. Herman; Roman Turczyn; Sławomir Boncel; Jerzy K. Zak
As numerous therapeutic agents are not well tolerated when administrated systemically, localized and controlled delivery can help to decrease their toxicity by applying an optimized drug concentration at extended exposure time. Among different types of drug delivery systems, conjugated polymers are considered as promising materials due to their biocompatibility, electrical conductivity and ability to undergo controllable redox reactions. In this work poly(3,4-ethylenedioxypyrrole), PEDOP, matrix is described for the first time as a reservoir of a model drug, ibuprofen (IBU). Drug immobilization process is performed in situ, during the electrochemical polymerization of 10 mM EDOP in the presence of 5-50 mM IBU. The loading efficiency of polymer matrix is dependent on IBU concentration and reaches 25.0±1.3 μg/cm2. The analysis of PEDOP-IBU chemical structure based on Raman spectroscopy, energy dispersive spectroscopy and surface morphology data provided by scanning electron microscopy shows that IBU is accumulated in the structure of matrix and evidently influences its morphology. IBU is then released in a controlled way under the influence of applied potential (-0.7 V vs. Ag/AgCl). It is demonstrated that the judicious choice of the synthesis conditions leads to a tailored loading efficiency of PEDOP matrix and to a tunable drug release.
Journal of Nanomaterials | 2017
Sławomir Boncel; Anna Pluta; Magdalena Skonieczna; Andrzej Gondela; Barbara Maciejewska; Artur P. Herman; Rafał G. Jędrysiak; Sebastian Budniok; K. Komędera; A. Błachowski; Krzysztof Walczak
Cell type, morphology, and functioning are key variables in the construction of efficient “drug-vehicle” hybrids in magnetic drug delivery. Iron-encapsulated multiwall carbon nanotubes (Fe@MWCNTs) appear as promising candidates for theranostics due to in situ chemical catalytic vapor deposition (c-CVD) synthesis, straightforward organic functionalization, and nanoneedle (1D) behavior. Here, model hybrids were synthesized by exploring C-sp2 chemistry ((1
RSC Advances | 2016
Artur P. Herman; Sławomir Boncel
Multi-wall carbon nanotubes (MWCNTs) were one-pot functionalized with a series of nitrile N-oxides as 1,3-dipoles carrying diverse functional groups. The degree of functionalization was found to be proportional to MWCNT defectivity. By selection of the 1,3-dipoles, functionalized MWCNTs exhibited programmable affinity to polar or non-polar systems.
International Journal of Nanomedicine | 2015
Nikodem Kuźnik; Mateusz Michał Tomczyk; Marzena Wyskocka; Łukasz Przypis; Artur P. Herman; Rafał G. Jędrysiak; Krzysztof Koziol; Sławomir Boncel
Iron-filled multiwall carbon nanotubes (Fe@MWCNTs) were functionalized toward a variety of potential magnetic resonance imaging contrast agents. Oxidized Fe@MWNCTs were covered with PEG5000 via direct esterification or using acyl chloride derivatives. Alternatively, the latter were functionalized with an aminophenol ligand (Fe@O-MWCNT-L). Moreover, pristine Fe@MWCNTs were functionalized with N-phenylaziridine groups (Fe@f-MWCNT) via [2+1] cycloaddition of nitrene. All of these chemically modified nanotubes served as a vehicle for anchoring Fe3+ ions. The new hybrids – Fe(III)/Fe@(f-/O-)MWCNTs – containing 6%–14% of the “tethered” Fe3+ions were studied in terms of the acceleration of relaxation of water protons in nuclear magnetic resonance. The highest transverse relaxivity r2=63.9±0.9 mL mg−1 s−1 was recorded for Fe(III)/Fe@O-MWCNT-L, while for Fe(III)/Fe@f-MWCNT, with r2=57.9±2.9 mL mg−1 s−1, the highest impact of the anchored Fe(III) ions was observed. The T1/T2 ratio of 30–100 found for all of the nanotube hybrids presented in this work is a very important factor for their potential application as T2 contrast agents. Increased stability of the hybrids was confirmed by ultraviolet–visible spectrophotometry.
Carbon | 2014
Dawid Janas; Artur P. Herman; Sławomir Boncel; Krzysztof Koziol
Enzyme and Microbial Technology | 2016
Aurelia Zniszczoł; Artur P. Herman; Katarzyna Szymańska; Julita Mrowiec-Białoń; Krzysztof Walczak; Andrzej B. Jarzębski; Sławomir Boncel
ACS Biomaterials Science & Engineering | 2016
Sławomir Boncel; Artur P. Herman; Sebastian Budniok; Rafał G. Jędrysiak; Agata Jakóbik-Kolon; Jeremy N. Skepper; Karin H. Müller
Materials Letters | 2014
Dawid Janas; Artur P. Herman; Sławomir Boncel; Krzysztof Koziol
Synthetic Metals | 2016
Katarzyna Krukiewicz; Tomasz Jarosz; Artur P. Herman; Roman Turczyn; Sławomir Boncel; Jerzy K. Zak