Asayuki Iwai

Hemorrhagic telangiectasia with thrombocytopenia in a newborn infant

consumptive thrombocytopenia, thrombopathy, coagulopathy and vasculopathy. There have also been rare cases with vascular malformation. Herein, we report on a female patient who presented at birth with ecchymoses, gastrointestinal hemorrhage, vitreum bleeding and thrombocytopenia. Some pathologic characteristics suggested an association with hereditary hemorrhagic telangiectasia (HHT). However, other clinical and pathologic features of the condition distinguished it from the reported spectrum of congenital HHT.

“Pulse” Methylprednisolone Therapy in the Treatment of Idiopathic Thrombocytopenic Purpura: A preliminary Report

Pulse‐mode methylprednisolone therapy was instituted in the treatment of idiopathic thrombocytopenic purpura (ITP), both acute and chronic forms. This regimen induced a rapid increase in the platelet count in a short time and was less toxic than the conventional mode of therapy, i.e. oral steroid hormone administration. This regimen is of value in the management of patients with ITP who are at the substantial risk of fatal hemorrhage. And this is also useful as a short‐term presplenectomy preparation or as a “medical splenectomy” program. Impressive responses in our experience encouraged us to evaluate this mode of therapy.