Atsuhiko Uemura

Lipase-catalyzed regioselective acylation of sugar moieties of nucleosides

Abstract A regioselective acylation of 2′-deoxypyrimidine nucleosides by an acid anhydride in a dry polar aprotic solvent is catalyzed by a lipase from Pseudomonas fluorescenbce.

Regioselective deprotection of 3′,5′-O-acylated pyrimidine nucleosides by lipase and esterase

Abstract A lipase was found to catalyze the regioselective hydrolysis at the secondary hydroxyl group of 2′-deoxy-3′,5′-di-O-hexanoyl pyrimidine nuclosides, whereas a protease catalyzes that at the primary hydroxyl group.

5-Fluorouracil derivatives. VII: Tert-amine promoted N-glycosidation of pyrimidines

Abstract Acylglycosyl halides react smoothly with N 1 - and N 3 -(octylthio)-carbonylpyrimidines in the presence of tert-amine to give the corresponding nucleosides in good yields.