Atsushi Mizota

Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population

Age-related macular degeneration (AMD) is a common cause of blindness in the elderly. Caucasian patients are predominantly affected by the dry form of AMD, whereas Japanese patients have predominantly the wet form of AMD and/or polypoidal choroidal vasculopathy (PCV). Although genetic association in the 10q26 (ARMS2/HTRA1) region has been established in many ethnic groups for dry-type AMD, typical wet-type AMD, and PCV, the contribution of the 1q32 (CFH) region seem to differ among these groups. Here we show a single nucleotide polymorphism (SNP) in the ARMS2/HTRA1 locus is associated in the whole genome for Japanese typical wet-type AMD (rs10490924:

One-Year Outcomes with Half-Dose Verteporfin Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

p = 4.1 times 10 ^{ - 4}

Reactive gliosis of astrocytes and Müller glial cells in retina of POMGnT1-deficient mice

, ORu2009=u20094.16) and PCV (rs10490924:

Outer Retinal Microstructure in a Case of Acute Idiopathic Blind Spot Enlargement Syndrome

p = 3.7 times 10 ^{ -8}

Costimulatory molecule expression on human uveal melanoma cells: functional analysis of CD40 and B7-H1.

, ORu2009=u20092.72) followed by CFH (rs800292: