Atsushi Ogihara

Relationship between Helicobacter pylori infection and smoking and drinking habits

Background : Helicobacter pylori is a major cause of various gastroduodenal diseases. Some risk factors related to H. pylori infection have been reported; however, studies on the relationship between H. pylori infection and smoking or drinking habits have given conflicting results. In the present study, these relationships were investigated by collecting sera and information from 8837 subjects.

Insufficient diagnostic accuracy of imported serological kits for Helicobacter pylori infection in Japanese population

Although there are many reports of the high diagnostic accuracy of commercially available serologic kits for Helicobacter pylori infection in Western countries, they rarely has been investigated in oriental population. Accordingly we examined their usefulness in 492 Japanese patients with dyspeptic symptoms. Diagnostic accuracy of 4 imported serologic kits (HEL-p TEST, HM CAP, G.A.P IgG, Helico G2) was investigated using the (13)C-urea breath test as the gold standard. When intermediate results were excluded, the sensitivity, specificity and accuracy of these serologic tests ranged from 88.6% to 97.8%, 67.9% to 85.9%, and 87.9% to 91.4%, respectively, which were comparable with reported median accuracy in the Western population. However, there were many intermediate results in these tests, ranging from 5.3% to 23.0%. Their usefulness seemed to be limited in our patient population because of the large number of intermediate results.

Trends in the incidence of gastric cancer in Japan and their associations with Helicobacter pylori infection and gastric mucosal atrophy

BackgroundAlthough age-adjusted mortality from gastric cancer has been decreasing in Japan, the crude incidence of gastric cancer shows a slight increase.MethodsWe have observed trends in the incidence of gastric cancer by sex and 20-year age groups over the past two decades (1976–1996). Source data were obtained from the cancer statistics materials provided by the Research Group for Population-Based Cancer Registration in Japan. Simultaneously, we observed changes in the prevalence of Helicobacter pylori infection and in serological atrophy of the gastric mucosa, and compared the results with those involving changes in the incidence of gastric cancer.ResultsA slight decline was observed in all age groups over 40 years old, in both men and women, between 1986 and 1996. However, a marked decline in incidence was observed for those aged 20–39 years. The prevalence of H. pylori infection declined in both sexes between 1989 and 1998. The frequency of serological atrophy of the gastric mucosa significantly declined in all age groups between 1989 and 1996, with young age groups experiencing a more marked decrease.ConclusionThe marked decline in gastric cancer incidence observed in the young population will also begin to occur in the elderly population in the future.

Analyzing the changes of health condition and social capital of elderly people using wearable devices

PurposeRapid developments in information technology have enabled wearable devices to be applied in the health field. In elderly adults, wearable devices aid in data collection and exerts a positive effect on their social capital. This study evaluated the changes in these two parameters among elderly adults using wearable devices, and analyzed the effect of these devices on their daily lives.MethodsWe selected 18 elderly people using wearable devices, between February and May 2017. The data collected by the wearable devices included the number of steps taken, sleep duration, blood pressure, heart rate, respiratory rate, fatigue, and mood of the wearers. Using a questionnaire and the trajectory equifinality model, we interviewed and surveyed elderly adults in order to understand their health status and social capital.ResultsThe health of the participants was generally good, and most were able to achieve > 8000 steps per day (p < 0.05). Mild and moderate fatigue symptoms were noted in elderly adults for 90% of the study period (p < 0.05). The number of steps, blood pressure, and heart rate changed significantly within a month. From the commencement of using the wearable devices, a steady increase was noted in the monthly number of steps. Interviews suggested that the elderly adults perceived wearable devices as having the potential to improve health and social capital.ConclusionsBy using wearable devices, the participants had a better understanding of their own health, and were willing to take health-boosting measures. The participants were also more willing to increase their social capital and expand their social network.

Ubi-Liven: A Human-Centric Safe and Secure Framework of Ubiquitous Living Environments for the Elderly

The world has become an aging society with exponentially increasing social security benefit expenditure and nursing care costs. To help solve these issues and challenges, utilization of advanced ICT is highly expected to allow more elderly people to remain independent for their proactive social participation irrespective of age. In this study, we propose a human-centric safe and secure framework of ubiquitous living environments (Ubi-Liven) for the elderly people towards seamless integration of the cyber-enabled ubiquitous holistic living support system with a physical living environment. We further address and discuss the design and technical issues for the implementation of a smart living environment on the fly under the proposed framework, empowered by ubiquitous assistive technologies such as cloud, IoT and big data analytics based on life logs to provide holistic support for the elderlys activities of daily living and healthcare.

Analysis of Health and Physiological Index Based on Sleep and Walking Steps by Wearable Devices for the Elderly

In this study, we use wearable devices to monitor the health and physiological indicators of the elderly, and analyze the effects of the elderlys walking steps and sleep as the measurable health and physiological indexes. Eighteen cases of the elderly who received health management services are selected. We establish the generalized linear mixed model, and Pearson correlation analysis result shows statistically significant for the number of walking steps and systolic blood pressure/diastolic blood pressure. The number of walking steps is positively correlated with the systolic/diastolic pressure. The more walking steps and the better the sleep quality, the more stable the daily blood pressure is. Therefore, it is possible to effectively control the elderlys blood pressure by exercising and managing sleeping. It can be better for the elderly to have self-esteem health managed by using wearable devices, and encourage the elderly to exercise at a certain extent.

Association between low maternal low-density lipoprotein cholesterol levels in the second trimester and delivery of small for gestational age infants at term: a case-control study of the national center for child health and development birth cohort.

Abstract Maternal malnutrition during pregnancy can lead to a small for gestational age (SGA) status among infants. In the present study, we compared the lipid levels during the second trimester in women who delivered SGA infants at term with those in women who delivered appropriate for gestational age infants at term, to examine whether abnormalities in maternal lipid levels could be a risk factor for the delivery of an SGA infant. We enrolled pregnant women who gave birth at the National Center for Child Health and Development (NCCHD), their infants, and who volunteered in a Birth cohort study at the NCCHD. We analyzed a total of 843 blood samples obtained from the women during the second trimester. Moreover, we used multi-regression analysis to assess the relationship between low-density lipoprotein cholesterol (LDL-C) levels during the second trimester and the risk of delivering an SGA infant. The adjusted odds ratio (OR) for LDL-C levels was 0.99 (95% CI, 0.98–0.99). These results indicate that a low LDL-C level during the second trimester was associated with an increased risk of delivering an SGA infant at term. The finding would not only help predict future SGA infant birth, but can also help prevent SGA infant birth.