Audrey M. Nelson
Mayo Clinic
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Mayo Clinic Proceedings | 1995
Lynne S. Peterson; Audrey M. Nelson; W.P. Daniel Su
OBJECTIVE To classify and describe morphea (localized scleroderma). DESIGN A review of morphea and its subtypes is presented. RESULTS The current classification of morphea is incomplete and confusing. As knowledge of the spectrum of disease continues to evolve, the controversy and confusing nature of its multiple subtypes present a challenge for the physician who encounters a patient with this condition. Thus, we propose that morphea be classified into the following five groups: plaque, generalized, bullous, linear, and deep. This classification, based on clinical morphologic findings, will simplify the diagnostic and therapeutic approach. CONCLUSION Morphea represents a wide variety of clinical entities that seen to be on the opposite end of the scleroderma spectrum from systemic sclerosis. The cutaneous lesions eventually evolve from a sclerotic stage to a nonindurated stage, and residual hypopigmentation or hyperpigmentation follows. The histologic pattern in patients with morphea is similar to that in patients with progressive systemic sclerosis. Although treatment is nonstandardized, hydroxychloroquine sulfate may be beneficial.
Arthritis & Rheumatism | 2001
Anthony R. French; Thomas Mason; Audrey M. Nelson; W. Michael O'Fallon; Sherine E. Gabriel
OBJECTIVE To assess mortality in a population-based cohort of adults with a history of juvenile rheumatoid arthritis (JRA). METHODS The Rochester Epidemiology Project database was used to identify all cases of JRA diagnosed among Rochester, Minnesota residents under the age of 16 between January 1, 1960 and December 31, 1993. Fifty-seven patients in this cohort are now adults (ages 18-53 years, mean age 34.3 years), and this subgroup was contacted for a long-term followup study. The average length of followup from the time of diagnosis was 25.6 years. RESULTS Four deaths occurred in this cohort of 57 adults with a history of JRA. All 4 deceased patients had other autoimmune illnesses and died of complications of these diseases. The observed frequency of 4 deaths was significantly greater (P < 0.0026 by one-sample log-rank test) than the 1 death that would be expected among Minnesota whites of similar age and sex, and corresponds to a mortality rate of 0.27 deaths per 100 years of patient followup compared with an expected mortality rate of 0.068 deaths per 100 years of followup in the general population. CONCLUSION The results indicate a significant, unexpected increase in mortality in this population-based cohort of adults with a history of JRA in comparison with the rate in the general population. The deaths in this group were all associated with other autoimmune disorders, suggesting that special emphasis should be given to the diagnosis and treatment of other autoimmune diseases, including immunodeficiencies, in JRA patients. The frequency of deaths in this cohort suggests that JRA patients are at substantial risk for mortality, and highlights the need for longitudinal followup and care into adulthood.
International Journal of Dermatology | 2006
Rokea A. el-Azhary; Carole C. Aponte; Audrey M. Nelson; Amy L. Weaver; Henry A. Homburger
Background Linear scleroderma occurs as two clinically distinct variants: the frontoparietal en coup de sabre type, and the torso‐extremity type. Antihistone antibodies (AHAs), which traditionally are markers for drug‐induced lupus, may also be linked to linear scleroderma.
Arthritis & Rheumatism | 1984
Joseph R. Hooyman; L. Joseph Melton; Audrey M. Nelson; W. Michael O'Fallon; B. Lawrence Riggs
The Journal of Rheumatology | 1997
L. S. Peterson; Audrey M. Nelson; W. P. Daniel Su; T. Mason; W. M. O'fallon; S. E. Gabriel
Arthritis & Rheumatism | 2004
Jörg J. Goronzy; Eric L. Matteson; James W. Fulbright; Kenneth J. Warrington; April Chang-Miller; Gene G. Hunder; Thomas Mason; Audrey M. Nelson; Robert M. Valente; Cynthia S. Crowson; Henry A. Erlich; Rebecca Reynolds; Ronald G. Swee; W. Michael O'Fallon; Cornelia M. Weyand
Arthritis & Rheumatism | 1997
Lynne S. Peterson; Thomas Mason; Audrey M. Nelson; W. Michael O'Fallon; Sherine E. Gabriel
Arthritis & Rheumatism | 1996
Lynne S. Peterson; Thomas Mason; Audrey M. Nelson; W. Michael O'Fallon; Sherine E. Gabriel
Arthritis & Rheumatism | 1983
Steven R. Towner Ba; Clement J. Michet; W. M. O'Fallon; Audrey M. Nelson
The Journal of Rheumatology | 2002
Anthony R. French; Thomas Mason; Audrey M. Nelson; Cynthia S. Crowson; W. Michael O'Fallon; Sundeep Khosla; Sherine E. Gabriel