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Featured researches published by Audrey M. Nelson.


Mayo Clinic Proceedings | 1995

Classification of Morphea (Localized Scleroderma)

Lynne S. Peterson; Audrey M. Nelson; W.P. Daniel Su

OBJECTIVE To classify and describe morphea (localized scleroderma). DESIGN A review of morphea and its subtypes is presented. RESULTS The current classification of morphea is incomplete and confusing. As knowledge of the spectrum of disease continues to evolve, the controversy and confusing nature of its multiple subtypes present a challenge for the physician who encounters a patient with this condition. Thus, we propose that morphea be classified into the following five groups: plaque, generalized, bullous, linear, and deep. This classification, based on clinical morphologic findings, will simplify the diagnostic and therapeutic approach. CONCLUSION Morphea represents a wide variety of clinical entities that seen to be on the opposite end of the scleroderma spectrum from systemic sclerosis. The cutaneous lesions eventually evolve from a sclerotic stage to a nonindurated stage, and residual hypopigmentation or hyperpigmentation follows. The histologic pattern in patients with morphea is similar to that in patients with progressive systemic sclerosis. Although treatment is nonstandardized, hydroxychloroquine sulfate may be beneficial.


Arthritis & Rheumatism | 2001

Increased mortality in adults with a history of juvenile rheumatoid arthritis: A population-based study

Anthony R. French; Thomas Mason; Audrey M. Nelson; W. Michael O'Fallon; Sherine E. Gabriel

OBJECTIVE To assess mortality in a population-based cohort of adults with a history of juvenile rheumatoid arthritis (JRA). METHODS The Rochester Epidemiology Project database was used to identify all cases of JRA diagnosed among Rochester, Minnesota residents under the age of 16 between January 1, 1960 and December 31, 1993. Fifty-seven patients in this cohort are now adults (ages 18-53 years, mean age 34.3 years), and this subgroup was contacted for a long-term followup study. The average length of followup from the time of diagnosis was 25.6 years. RESULTS Four deaths occurred in this cohort of 57 adults with a history of JRA. All 4 deceased patients had other autoimmune illnesses and died of complications of these diseases. The observed frequency of 4 deaths was significantly greater (P < 0.0026 by one-sample log-rank test) than the 1 death that would be expected among Minnesota whites of similar age and sex, and corresponds to a mortality rate of 0.27 deaths per 100 years of patient followup compared with an expected mortality rate of 0.068 deaths per 100 years of followup in the general population. CONCLUSION The results indicate a significant, unexpected increase in mortality in this population-based cohort of adults with a history of JRA in comparison with the rate in the general population. The deaths in this group were all associated with other autoimmune disorders, suggesting that special emphasis should be given to the diagnosis and treatment of other autoimmune diseases, including immunodeficiencies, in JRA patients. The frequency of deaths in this cohort suggests that JRA patients are at substantial risk for mortality, and highlights the need for longitudinal followup and care into adulthood.


International Journal of Dermatology | 2006

Antihistone antibodies in linear scleroderma variants.

Rokea A. el-Azhary; Carole C. Aponte; Audrey M. Nelson; Amy L. Weaver; Henry A. Homburger

Background  Linear scleroderma occurs as two clinically distinct variants: the frontoparietal en coup de sabre type, and the torso‐extremity type. Antihistone antibodies (AHAs), which traditionally are markers for drug‐induced lupus, may also be linked to linear scleroderma.


Arthritis & Rheumatism | 1984

Fractures after rheumatoid arthritis. A population-based study.

Joseph R. Hooyman; L. Joseph Melton; Audrey M. Nelson; W. Michael O'Fallon; B. Lawrence Riggs


The Journal of Rheumatology | 1997

The epidemiology of morphea (localized scleroderma) in Olmsted County 1960-1993

L. S. Peterson; Audrey M. Nelson; W. P. Daniel Su; T. Mason; W. M. O'fallon; S. E. Gabriel


Arthritis & Rheumatism | 2004

Prognostic markers of radiographic progression in early rheumatoid arthritis

Jörg J. Goronzy; Eric L. Matteson; James W. Fulbright; Kenneth J. Warrington; April Chang-Miller; Gene G. Hunder; Thomas Mason; Audrey M. Nelson; Robert M. Valente; Cynthia S. Crowson; Henry A. Erlich; Rebecca Reynolds; Ronald G. Swee; W. Michael O'Fallon; Cornelia M. Weyand


Arthritis & Rheumatism | 1997

Psychosocial outcomes and health status of adults who have had juvenile rheumatoid arthritis. A controlled, population‐based study

Lynne S. Peterson; Thomas Mason; Audrey M. Nelson; W. Michael O'Fallon; Sherine E. Gabriel


Arthritis & Rheumatism | 1996

Juvenile rheumatoid arthritis in Rochester, Minnesota 1960-1993 : Is the epidemiology changing ?

Lynne S. Peterson; Thomas Mason; Audrey M. Nelson; W. Michael O'Fallon; Sherine E. Gabriel


Arthritis & Rheumatism | 1983

The epidemiology of juvenile arthritis in rochester, minnesota 1960–1979

Steven R. Towner Ba; Clement J. Michet; W. M. O'Fallon; Audrey M. Nelson


The Journal of Rheumatology | 2002

Osteopenia in adults with a history of juvenile rheumatoid arthritis. A population based study

Anthony R. French; Thomas Mason; Audrey M. Nelson; Cynthia S. Crowson; W. Michael O'Fallon; Sundeep Khosla; Sherine E. Gabriel

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Anthony R. French

Washington University in St. Louis

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