Aya Shoda
Mitsubishi Tanabe Pharma
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Publication
Featured researches published by Aya Shoda.
Bioorganic & Medicinal Chemistry Letters | 2013
Fumiaki Uehara; Aya Shoda; Keiichi Aritomo; Kenji Fukunaga; Kazutoshi Watanabe; Ryoichi Ando; Masaki Shinoda; Hiroaki Ueno; Hideo Kubodera; Shinji Sunada; Kenichi Saito; Takahide Kaji; Shoichi Asano; Jun-ichi Eguchi; Satoshi Yuki; Shinji Tanaka; Yukimi Yoneyama
The discovery of a series of 6-(4-pyridyl)pyrimidin-4(3H)-ones derived from a hit compound with low molecular weight and sufficient chemical space is reported. Transformation of substituents led to subnanomolar potent inhibitors with in vivo tau phoshorylation lowering activity.
Bioorganic & Medicinal Chemistry Letters | 2013
Kenji Fukunaga; Fumiaki Uehara; Keiichi Aritomo; Aya Shoda; Shinsuke Hiki; Masahiro Okuyama; Yoshihiro Usui; Kazutoshi Watanabe; Koichi Yamakoshi; Toshiyuki Kohara; Tokushi Hanano; Hiroshi Tanaka; Susumu Tsuchiya; Shinji Sunada; Kenichi Saito; Jun-ichi Eguchi; Satoshi Yuki; Shoichi Asano; Shinji Tanaka; Akiko Mori; Keiji Yamagami; Hiroshi Baba; Takashi Horikawa; Masatake Fujimura
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with good in vitro PK profiles. 21 demonstrated significant decrease of tau phosphorylation after oral administration in mice and excellent PK profiles.
Archive | 2002
Fumiaki Uehara; Keiichi Aritomo; Aya Shoda; Shinsuke Hiki; Masahiro Okuyama; Yoshihiro Usui; Mitsuru Ooizumi; Kazutoshi Watanabe
Archive | 2001
Garcia Antonio Almario; Ryoichi Ando; Jonathan Reid Frost; Adrien Tak Li; Aya Shoda
Archive | 2004
Kazutoshi Watanabe; Fumiaki Uehara; Shinsuke Hiki; Satoshi Yokoshima; Yoshihiro Usui; Masahiro Okuyama; Aya Shoda; Keiichi Aritomo; Toshiyuki Kohara; Kenji Fukunaga
Archive | 2001
Garcia Antonio Almario; Ryoichi Ando; Keiichi Aritomo; Jonathan Reid Frost; Adrien Tak Li; Aya Shoda; Fumiaki Uehara; Kazutoshi Watanabe
Archive | 2005
Antonio Almario Carcia; Ryoichi Ando; Keiichi Arimoto; Fumiaki Uehara; Adrien Tak Li; Aya Shoda; Jonathan Reid Frost; Kazutoshi Watanabe
Archive | 2004
Kazutoshi Watanabe; Fumiaki Uehara; Shinsuke Hiki; Satoshi Yokoshima; Toshiyuki Kohara; Kenji Fukunaka; Yoshihiro Usui; Masahiro Okuyama; Aya Shoda; Keiichi Aritomo
Archive | 2002
Kazutoshi Watanabe; Aya Shoda; Ryoichi Ando; Kenichi Saito; Rie Kawamoto
Archive | 2002
Fumiaki Uehara; Keiichi Aritomo; Aya Shoda; Shinsuke Hiki; Masahiro Okuyama; Yoshihiro Usui; Mitsuru Ooizumi; Kazutoshi Watanabe
