B. Craige

THE THERAPEUTIC EFFECTIVENESS OF LARGE DOSES OF PALUDRINE IN ACUTE ATTACKS OF SPOROZOITE-INDUCED VIV AX MALARIA (CHESSON STRAIN)

1 This investigation was carried out under contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the University of Chicago. The studies were planned in cooperation with the Panel on Clinical Testing of Antimalarials of the Board for the Coordination of Malarial Studies. This work was further aided by the participation of Army Medical Officers assigned to the project by the Surgeon General, U. S. Army. Through a cooperative arrangement between Professor Clay G. Huff and Dr. Frederick Coulston, Department of Bacteriology and Parasitology, and the Malarial Research Unit, Department of Medicine, the former group bred Anopheles quadrimaculatus mosquitoes, supervised their infection and the inoculation of volunteers, and determined the intensity of infection in the salivary glands of the mosquitoes. The latter group assumed the responsibility for clinical care of patients studied by both groups. The authors express their thanks to the Malaria Study Section of the National Institute of Health for editorial assistance and for arrangements in regard to the publication of this paper. They are also grateful to the Abbott Laboratories, E. I. du Pont de Nemours and Company, Inc., E. R. Squibb and Sons, Eli Lilly and Company, Sharp and Dohme, Inc., and Wyeth, Inc., for contributing toward the publication costs. 2 Captain, M.C., A.U.S. produce clinical cure of relapses and delayed primary attacks of naturally acquired zivax malaria. The drug is well tolerated in doses as high as 1.5 grams a day for 14 to 28 days. In 157 cases of vivax malaria treated with paludrine in doses of 20 to 1,500 mgm. per day for 14 to 28 days, however, the effect on the relapse rate was no greater than that of quinacrine. Wehave studied the effect of paludrine against a standardized infection of a Southwest Pacific strain of vivax malaria in order to compare it with suppressive agents, and have attempted to determine whether or not it exhibits synergistic action with quinine or pentaquine.