B. Miles

Variation in functional pelvic tilt in patients undergoing total hip arthroplasty

Aims The pelvis rotates in the sagittal plane during daily activities. These rotations have a direct effect on the functional orientation of the acetabulum. The aim of this study was to quantify changes in pelvic tilt between different functional positions. Patients and Methods Pre‐operatively, pelvic tilt was measured in 1517 patients undergoing total hip arthroplasty (THA) in three functional positions ‐ supine, standing and flexed seated (the moment when patients initiate rising from a seated position). Supine pelvic tilt was measured from CT scans, standing and flexed seated pelvic tilts were measured from standardised lateral radiographs. Anterior pelvic tilt was assigned a positive value. Results The mean pelvic tilt was 4.2° (‐20.5° to 24.5°), ‐1.3° (‐30.2° to 27.9°) and 0.6° (‐42.0° to 41.3°) in the three positions, respectively. The mean sagittal pelvic rotation from supine to standing was ‐5.5° (‐21.8° to 8.4°), from supine to flexed seated was ‐3.7° (‐48.3° to 38.6°) and from standing to flexed seated was 1.8° (‐51.8° to 39.5°). In 259 patients (17%), the extent of sagittal pelvic rotation could lead to functional malorientation of the acetabular component. Factoring in an intra‐operative delivery error of ± 5° extends this risk to 51% of patients. Conclusion Planning and measurement of the intended position of the acetabular component in the supine position may fail to predict clinically significant changes in its orientation during functional activities, as a consequence of individual pelvic kinematics. Optimal orientation is patient‐specific and requires an evaluation of functional pelvic tilt pre‐operatively.

Functional orientation of the acetabular component in ceramic-on-ceramic total hip arthroplasty and its relevance to squeaking

AIMS Long-term clinical outcomes for ceramic-on-ceramic (CoC) bearings are encouraging. However, there is a risk of squeaking. Guidelines for the orientation of the acetabular component are defined from static imaging, but the position of the pelvis and thus the acetabular component during activities associated with edge-loading are likely to be very different from those measured when the patient is supine. We assessed the functional orientation of the acetabular component. PATIENTS AND METHODS A total of 18 patients with reproducible squeaking in their CoC hips during deep flexion were investigated with a control group of 36 non-squeaking CoC hips. The two groups were matched for the type of implant, the orientation of the acetabular component when supine, the size of the femoral head, ligament laxity, maximum hip flexion and body mass index. RESULTS The mean functional anteversion of the acetabular component at the point when patients initiated rising from a seated position was significantly less in the squeaking group than in the control group, 8.1° (-10.5° to 36.0°) and 21.1° (-1.9° to 38.4°) respectively (p = 0.002). CONCLUSION The functional orientation of the acetabular component during activities associated with posterior edge-loading are different from those measured when supine due to patient-specific pelvic kinematics. Individuals with a large anterior pelvic tilt during deep flexion might be more susceptible to posterior edge-loading and squeaking as a consequence of a significant decrease in the functional anteversion of the acetabular component. Cite this article: Bone Joint J 2016;98-B:910-16.

Variability in static alignment and kinematics for kinematically aligned TKA

BACKGROUND Total knee arthroplasty (TKA) significantly improves pain and restores a considerable degree of function. However, improvements are needed to increase patient satisfaction and restore kinematics to allow more physically demanding activities that active patients consider important. The aim of our study was to compare the alignment and motion of kinematically and mechanically aligned TKAs. METHODS A patient specific musculoskeletal computer simulation was used to compare the tibio-femoral and patello-femoral kinematics between mechanically aligned and kinematically aligned TKA in 20 patients. RESULTS When kinematically aligned, femoral components on average resulted in more valgus alignment to the mechanical axis and internally rotated to surgical transepicondylar axis whereas tibia component on average resulted in more varus alignment to the mechanical axis and internally rotated to tibial AP rotational axis. With kinematic alignment, tibio-femoral motion displayed greater tibial external rotation and lateral femoral flexion facet centre (FFC) translation with knee flexion than mechanical aligned TKA. At the patellofemoral joint, patella lateral shift of kinematically aligned TKA plateaued after 20 to 30° flexion while in mechanically aligned TKA it decreased continuously through the whole range of motion. CONCLUSIONS Kinematic alignment resulted in greater variation than mechanical alignment for all tibio-femoral and patello-femoral motion. Kinematic alignment places TKA components patient specific alignment which depends on the preoperative state of the knee resulting in greater variation in kinematics. The use of computational models has the potential to predict which alignment based on native alignment, kinematic or mechanical, could improve knee function for patients undergoing TKA.

Measurement of physical activity in the pre- and early post-operative period after total knee arthroplasty for Osteoarthritis using a Fitbit Flex device

Total knee arthroplasty (TKA) is a standard treatment for patients with end stage knee Osteoarthritis (OA) to reduce pain and restore function. The aim of this study was to assess pre- and early post-operative physical activity (PA) with Fitbit Flex devices for patients with OA undergoing TKA and determine any benchmarks for expected post-operative activity. Significant correlations of pre-operative step count, post-operative step count, Body Mass Index (BMI) and Short Form 12 Physical Component Summaries (SF-12 PCS) were found. Mean step counts varied by 3,203 steps per day between obese and healthy weight patients, and 3,786 steps per day between those with higher and lower SF-12 PCS scores, suggesting the need for benchmarks for recovery that vary by patient pre-operative factors. A backwards stepwise regression model developed to provide patient specific step count predictions at 6 weeks had an R2 of 0.754, providing a robust patient specific benchmark for post-operative recovery, while population means from BMI and SF-12 subgroups provide a clinically practical alternative.

Subject specific finite element modeling of periprosthetic femoral fracture using element deactivation to simulate bone failure

Subject-specific finite element (FE) modeling methodology could predict peri-prosthetic femoral fracture (PFF) for cementless hip arthoplasty in the early postoperative period. This study develops methodology for subject-specific finite element modeling by using the element deactivation technique to simulate bone failure and validate with experimental testing, thereby predicting peri-prosthetic femoral fracture in the early postoperative period. Material assignments for biphasic and triphasic models were undertaken. Failure modeling with the element deactivation feature available in ABAQUS 6.9 was used to simulate a crack initiation and propagation in the bony tissue based upon a threshold of fracture strain. The crack mode for the biphasic models was very similar to the experimental testing crack mode, with a similar shape and path of the crack. The fracture load is sensitive to the friction coefficient at the implant-bony interface. The development of a novel technique to simulate bone failure by element deactivation of subject-specific finite element models could aid prediction of fracture load in addition to fracture risk characterization for PFF.

A plasma-sprayed titanium proximal coating reduces the risk of periprosthetic femoral fracture in cementless hip arthroplasty.

BACKGROUND The design of femoral component used in total hip arthroplasty is known to influence the incidence of periprosthetic femoral fractures (PFFs) in cementless hip arthroplasty. OBJECTIVE This study was undertaken to determine if 2 potential changes to an existing ABG II-standard cementless implant - addition of a roughened titanium plasma-sprayed proximal coating (ABG II-plasma) and lack of medial scales (ABG II-NMS) could decrease the risk of PFF in the intraoperative and early postoperative periods. METHODS Six pairs of human cadaveric femurs were harvested and divided into 2 groups, each receiving either of the altered implants and ABG II-standard (control). Each implant was tested in a biomechanical setup in a single-legged stance orientation. Surface strains were measured in intact femurs, during implant insertion, cyclic loading of the bone with the implant, and loading to failure. Strains with the ABG II-standard and the altered implants were compared. FINDINGS ABG II-plasma showed better load-bearing capacity, with an average 42% greater failure load than that of ABG II-standard. The cortical hoop, axial and mean strains ABG II-plasma were less than those of ABG II-standard, demonstrating decreased tensile behaviour and better load transfer to the proximal femur. The final residual hoop strains in ABG II-plasma were closer to those of intact bone as compared to the standard stem. No differences in strains were observed between the standard stem and ABG II-NMS. CONCLUSION The increased load-bearing capacity and decreased proximal surface strains on femurs implanted with ABG II-plasma stem should reduce the risks of intraoperative and early postoperative PFF.

The effect of seated pelvic tilt on posterior edge-loading in total hip arthroplasty: A finite element investigation

Edge-loading of a ceramic-on-ceramic total hip replacement can lead to reproducible squeaking and revision. A patient’s functional acetabular cup orientation, driven by their pelvic tilt, has been shown to be a significant factor in squeaking during hip flexion. The aim of this study was to investigate the effect of seated pelvic tilt on the contact mechanics at the ceramic bearing surface. A finite element model of a ceramic-on-ceramic total hip replacement was created. The cup was orientated at 40° inclination and 15° anteversion relative to the anterior pelvic plane. The stem was flexed 90° to replicate sitting in a chair. The model was loaded using data from in vivo measurements taken during a sit-to-stand activity. The pelvis was modelled in seven different sagittal positions, ranging from −30° to 30° of pelvic tilt, where a positive value denotes anterior pelvic tilt. Three different head sizes were investigated: 32, 36 and 40 mm. The maximum contact pressure and contact patch to rim distance were determined for each of the 21 simulations. Edge-loading (contact patch to rim distance < 0 mm) occurred with all head sizes when seated pelvic tilt was ≥10° and induced a large increase in contact pressure on the liner, with a maximum pressure exceeding 500 MPa. Edge-loading initiated at seated pelvic tilts of 7°, 9° and 5° for the 32, 36 and 40 mm heads, respectively. Patients with anterior pelvic tilts in the seated position are susceptible to posterior edge-loading. As the position of the pelvis when seated is patient specific, cup orientation should be adjusted on an individual basis to minimise edge-loading.

Patient Variation Limits Use of Fixed References for Femoral Rotation Component Alignment in Total Knee Arthroplasty

BACKGROUND Optimal rotational alignment of the femoral component is a common goal during total knee arthroplasty. The posterior condylar axis (PCA) is thought to be the most reproducible reference in surgery, while the transepicondylar axis (TEA) seems to better approximate the native kinematic flexion axis. This study sought to determine if rules based on patient gender or coronal alignment could allow reliable reproduction of the TEA from the PCA. METHODS Three-dimensional models based on preoperative computed tomography were made representing a patients arthritic knee joint. The landmarks were defined and angular relationships determined. RESULTS The population group of 726 patients contained large anatomic variation. When applying the standard reference rule of 3° external rotation from the PCA, 36.9% of patients would have a rotational target greater than ±2° from their TEA. When applying the mean external rotation of the TEA from the PCA (1.85°) from this population, this proportion dropped to 26.0% of patients. The use of statistically significant gender and coronal alignment relationships to define the femoral rotation did not reduce the proportion of patients in ±2° error. CONCLUSION This study shows that gender and coronal alignment relationships to the TEA to PCA angle are not clinically significant as a quarter of patients would still have a target for rotation greater than ±2° from the TEA using these relationships. Superior tools for orienting rotational cuts directly to the TEA in surgery or preoperative identification of relevant patient-specific angles might capture the proportion of patients for whom standard reference angles are not appropriate.

Biomechanical optimization of subject-specific implant positioning for femoral head resurfacing to reduce fracture risk

Peri-prosthetic femoral neck fracture after femoral head resurfacing can be either patient-related or surgical technique-related. The study aimed to develop a patient-specific finite element modelling technique that can reliably predict an optimal implant position and give minimal strain in the peri-prosthetic bone tissue, thereby reducing the risk of peri-prosthetic femoral neck fracture. The subject-specific finite element modelling was integrated with optimization techniques including design of experiments to best possibly position the implant for achieving minimal strain for femoral head resurfacing. Sample space was defined by varying the floating point to find the extremes at which the cylindrical reaming operation actually cuts into the femoral neck causing a notch during hip resurfacing surgery. The study showed that the location of the maximum strain, for all non-notching positions, was on the superior femoral neck, in the peri-prosthetic bone tissue. It demonstrated that varus positioning resulted in a higher strain, while valgus positioning reduced the strain, and further that neutral version had a lower strain.

Subject-specific finite element model with an optical tracking system in total hip replacement surgery

Intra-operative peri-prosthetic femoral fractures are a significant concern in total hip arthroplasty and can occur at any time during surgery, with the highest incidence during implant insertion. This study combines subject-specific finite element analysis modeling with an optical tracking system to characterize the resultant strain in the bone and results of impaction during total hip replacement surgery. The use of ABG II femoral stem (Stryker Orthopaedics, Mahwah, NJ, USA) in the model yielded the following results. Hammer velocity was measured experimentally using a three-dimensional optical tracking system and these data were input into the finite element analysis model so that intra-operative loading scenario could be simulated. A quasi-static explicit simulation and a dynamic loading step using two implant–bone interface friction (0.1 and 0.4 friction coefficients) states were simulated. The maximum swing velocity of a mallet was experimentally measured at 1.5 m/s and occurred just before impaction of the hammer with implant introducer. Two friction states resulted in different results with the lower friction coefficient generating higher strains in the anterior regions of the model and higher displacement of the implant with respect to the femur when compared to the high friction state.