B. P. Bandgar

Molecular iodine-catalyzed efficient and highly rapid synthesis of bis(indolyl)methanes under mild conditions

Highly rapid and efficient electrophilic substitution reactions of indoles with various aldehydes and ketones were carried out using I2 in CH3CN to afford the corresponding bis(indolyl)methanes in excellent yields.

Synthesis of acyl azides from carboxylic acids using cyanuric chloride

A mild, efficient and general method for the preparation of acyl azides from carboxylic acids and sodium azide using cyanuric chloride is described.

Direct synthesis of 2-oxazolines from carboxylic acids using 2-chloro-4,6-dimethoxy-1,3,5-triazine under mild conditions

2-Acyloxy-4,6-dimethoxy-1,3,5-triazines obtained from carboxylic acids and 2-chloro-4,6-dimethoxy-1,3,5-triazine were subsequently treated with 2-amino-2-methyl-1-propanol to afford the corresponding 2-oxazolines in excellent yield at room temperature.

In-vitro evaluation of selected chalcones for antioxidant activity

Synthetic chalcones (SCs) having different side chains on the 1-(2-Hydroxy-3-(2-hydroxy-cyclohexyl)-4,6 dimethoxy-phenyl(-methanone structure were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine) radical scavenging activity, reducing ability, OH radical scavenging activity, inhibition of polyphenol oxidase (PPO) and formation of diene conjugates. Overall, with few exceptions, all the SCs showed moderate biological activity in all the parameters examined. The SCs were found to be reactive towards DPPH radical and had considerable reducing ability. With few exceptions, all the test compounds under study were found to possess moderate to poor OH radical scavenging activity and inhibited PPO significantly and all were found to be effective inhibitors of hydroperoxide formation. These findings suggest that these SCs can be considered as potential antioxidant agents which might be further explored for the design of lead antioxidant drug candidates.

Reduction of sulfur with borohydride exchange resin in methanol: application to rapid and selective synthesis of disulfides

Abstract A convenient and rapid method for the synthesis of symmetrical disulfides from alkyl or aryl alkyl halides using sulfurated borohydride exchange resin (SBER) under anhydrous conditions is described. Selective transfer of sulfur to an alkyl group rather than an aryl group is achieved using this methodology.

Molecular Iodine Catalyzed Highly Rapid Synthesis of 1,5‐Benzodiazepine Derivatives Under Mild Conditions

Abstract Rapid reaction of o‐phenylenediamines with both cyclic and acyclic ketones in the presence of catalytic amount of iodine afforded 1,5‐benzodiazepine derivatives in excellent yields at room temperature.

An expedient and highly selective iodination of alcohols using a KI/BF3·Et2O system

Alkyl iodides are prepared in high yields by treatment of allylic and benzylic alcohols with an equimolar amount of KI in the presence of BF3·Et2O in dioxane under mild conditions.

Montmorillonite K-10 catalyzed synthesis of β-keto esters: condensation of ethyl diazoacetate with aldehydes under mild conditions

A simple and efficient synthesis of β-keto esters using montmorillonite K-10 catalyzed condensation of ethyl diazoacetate with various aldehydes at room temperature is described.

Organic Reactions in Water: Transformation of Aldehydes to Nitriles using NBS under Mild Conditions

Abstract Aliphatic, aromatic, heterocyclic, conjugated, and polyhydroxy aldehydes gave corresponding nitriles in high yields at 0°C using NBS and ammonia in water.

A mild procedure for rapid and selective deprotection of aryl acetates using natural kaolinitic clay as a reusable catalyst

Abstract A variety of aryl acetates are selectively cleaved to the corresponding phenols using natural kaolinitic clay in methanol under mild conditions (25°C).