Vinod T. Kamble

Eco-friendly polyethylene glycol-400: a rapid and efficient recyclable reaction medium for the synthesis of thiazole derivatives

Abstract An efficient and convenient procedure for the synthesis of thiazole derivatives from α-haloketone, thiourea and substituted acetophenones using polyethylene glycol-400 as a green and recyclable solvent is described. Significant rate enhancement and improved yields have been observed.

An Efficient and Green Procedure for the Preparation of 2-{2-[N′-(2-Hydroxybenzylidene)hydrazino]thiazol-4-yl}phenols

An efficient and convenient approach for the synthesis of thiazole derivatives from α-halo ketones, thiosemicarbazide, and o-hydroxybenzaldehydes in poly(ethylene glycol) (PEG-400) is described. The preparation procedure presented is operationally simple and environmentally benign. Some of the major advantages of this procedure are high yields and ease of operation.

Iron(III) fluoride : A highly efficient and versatile catalyst for the protection of carbonyl compounds under solvent-free conditions

Carbonyl compounds are successfully converted into oxathioacetals and dithioacetals with 2-mercaptoethanol and ethane-1,2-dithiol using a catalytic amount of iron(iii) fluoride under solvent-free conditions. The catalysts were recovered and reused in various runs without affecting the efficiency of the process.

Convenient and Efficient Synthesis of Thiol Esters using Zinc Oxide as a Heterogeneous and Eco-Friendly Catalyst

A catalytic method was developed to synthesize thiol esters from the reaction of acyl chlorides and thiols using zinc oxide as a catalyst under solvent-free conditions at room temperature. Mild reaction conditions, short reaction time, excellent yields of products and recyclability of the catalyst are noteworthy features of this methodology.

Cyanuric Chloride : an Efficient Catalyst for Ring Opening of Epoxides with Thiols Under Solvent-Free Conditions

2,4,6-Trichloro-1,3,5-triazine-catalyzed convenient and efficient ring opening of epoxides with thiols under solvent-free conditions is described. Short reaction time, mild reaction conditions, inexpensive and readily available catalyst, and excellent yields of products are attractive features of this methodology.

Green Protocol for Synthesis of Bis-indolylmethanes and Bis-indolylglycoconjugates in the Presence of Iron(iii) Fluoride as a Heterogeneous, Reusable, and Eco-Friendly Catalyst

An efficient method for the preparation of bis-indolylmethanes and bis-indolylglycoconjugates from carbonyl compounds with indoles in the presence of a catalytic amount of iron(iii) fluoride under solvent-free conditions is reported. The desired products were obtained in high yields with a simple and environmentally benign procedure. The use of iron(iii) fluoride is feasible because of its stability, easy handling, easy recovery, reusability, and good activity.

Synthesis of β-amino alcohols by ring opening of epoxides with amines catalyzed by cyanuric chloride under mild and solvent-free conditions

Abstract The 2,4,6-trichloro-1,3,5-triazine catalyzed synthesis of β-amino alcohols by aminolysis of epoxide under solvent-free condition is described. Mild reaction conditions, short reaction times, inexpensive and readily available catalysts, and excellent yields of the products with high regioselectivity are attractive features of this methodology.

Multicomponent One-Pot Synthesis of Substituted Hantzsch Thiazole Derivatives Under Solvent Free Conditions

Thiazole derivatives were prepared by one-pot procedure by the reaction of α-haloketones, thiourea and substituted o-hydroxybenzaldehyde under environmentally solvent free conditions.

Synthesis and Evaluation of New 4-Chloro-2-(3-chloro-4-fluorophenyl)-5-(aliphatic/cyclic saturated amino)pyridazin-3(2H)-one Derivatives as Anticancer, Antiangiogenic, and Antioxidant Agents

Pyridazinones are widely recognized as versatile scaffolds with a wide spectrum of biological activities. In the present work, a series of new 4‐chloro‐2‐(3‐chloro‐4‐fluorophenyl)‐5‐(aliphatic/cyclic saturated amino)pyridazin‐3(2H)‐one derivatives 4a–i were synthesized and characterized by spectral techniques. The inhibitory effects of the synthesized compounds 4a–i on the viability of three human cancer cell lines, HEP3BPN 11 (liver), MDA 453 (breast), and HL 60 (leukemia), were assessed using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) reduction assay. Among the compounds 4a–i screened, 4g and 4i exhibited inhibitory activity very close to the standard methotrexate; therefore, these lead compounds were further tested for their potential to inhibit the proangiogenic cytokines involved in tumor progression. Compound 4g was found to be a potent antiangiogenic agent against TNFα, VEGF, FGFb, and TGFβ, whereas 4i showed potent antiangiogenic activity against TNFα, VEGF, FGFb, and leptin. All the compounds 4a–i were screened for their antioxidant activities using 2,2‐diphenyl‐1‐picryl hydrazine (DPPH), OH, and superoxide anion radicals. Compound 4f showed better OH radical scavenging activity than the standard ascorbic acid.

Magnesium perchlorate : an efficient catalyst for selective sulfonylation of arenes under neutral conditions

Magnesium perchlorate is found to be an extremely efficient catalyst for the sulfonylation of activated, unactivated and heterocyclic aromatics under almost neutral conditions.