Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where B.P. Rajlawat is active.

Publication


Featured researches published by B.P. Rajlawat.


Oral Oncology | 2012

The clinical determinants of malignant transformation in oral epithelial dysplasia

Michael Ho; Janet M. Risk; Julia A. Woolgar; E.A. Field; John K. Field; J. C. Steele; B.P. Rajlawat; Asterios Triantafyllou; Simon N. Rogers; Derek Lowe; Richard Shaw

BACKGROUND While the size and clinical appearance are known risk factors for malignant transformation of potentially malignant oral the importance of site, grade of dysplasia and exposure to environmental carcinogens remains controversial. We aim to report the clinical determinants of malignant progression in a series of patients with histopathologically graded oral epithelial dysplasia (OED). METHODS We recruited patients with a histopathological diagnosis of OED to a longitudinal observational study in a tertiary oral dysplasia clinic. Clinical, histopathological and risk factor data were recorded at baseline. One of three clinical endpoints were determined: malignant transformation, progression of dysplasia grade, remission/stable dysplasia grade. RESULTS Ninety-one patients meeting the criteria gave consent for inclusion to the cohort, with outcomes reported after a median follow up of 48 months. An estimated 22% (SE 6%) of patients underwent malignant transformation within 5 years, with significant predictors being: non-smoking status (χ(2)=15.1, p=0.001), site (χ(2)=15.3, p=0.002), non-homogeneous appearance (χ(2)=8.2, p=0.004), size of lesion >200 mm(2) (χ(2)=4.7, p=0.03) and, of borderline significance, high grade (χ(2)=5.8, p=0.06). Gender, age, number of lesions and alcohol history did not predict for malignant transformation. CONCLUSIONS Although a number of these clinical determinants have previously been associated with higher malignant transformation in OED, the high-risk nature of lesions in non-smokers is of particular note and requires a greater emphasis and recognition amongst clinicians dealing with OED. It suggests that those non-smokers with OED, have an inherited or acquired predisposition and should be treated more aggressively; these should form the focus for further investigation.


British Journal of Oral & Maxillofacial Surgery | 2013

Outcomes of oral squamous cell carcinoma arising from oral epithelial dysplasia: rationale for monitoring premalignant oral lesions in a multidisciplinary clinic.

Michael Ho; E.A. Field; John K. Field; Janet M. Risk; B.P. Rajlawat; Simon N. Rogers; J. C. Steele; Asterios Triantafyllou; Julia A. Woolgar; Derek Lowe; Richard Shaw

Surveillance of oral epithelial dysplasia results in a number of newly diagnosed cases of oral squamous cell carcinoma (SCC). The clinical stage of oral SCC at diagnosis influences the magnitude of treatment required and the prognosis. We aimed to document the stage, treatment, and outcome of oral SCC that arose in patients who were being monitored for oral epithelial dysplasia in a dedicated multidisciplinary clinic. Those with histologically diagnosed lesions were enrolled on an ethically approved protocol and molecular biomarker study. Details of clinical and pathological TNM, operation, radiotherapy, recurrence, second primary tumour, and prognosis, were recorded in patients whose lesions underwent malignant transformation. Of the 91 patients reviewed (median follow-up 48 months, IQR 18-96), 23 (25%) had malignant transformation. All were presented to the multidisciplinary team with stage 1 disease (cT1N0M0). Of these, 21 were initially treated by wide local excision, 2 required resection of tumour and reconstruction, and 2 required adjuvant radiotherapy. At follow-up 3 had local recurrence, one had regional recurrence, one had metachronous lung cancer, and 5 had second primary oral SCC. There were further diagnoses of oral dysplasia in 5 during follow-up, and it is estimated that 76% of patients will have one or other event in 5 years. Disease-specific survival was 100% and overall survival was 96% (22/23). Median follow-up after diagnosis of oral SCC was 24 months (IQR 11-58). Specialist monitoring of oral epithelial dysplasia by a multidisciplinary team allows oral SCC to be detected at an early stage, and enables largely curative treatment with simple and usually minor surgical intervention. The high incidence of second primary oral SCC in high-risk patients with oral epithelial dysplasia further supports intensive targeted surveillance in this group.


Head and Neck-journal for The Sciences and Specialties of The Head and Neck | 2006

COMPARISON OF THE DOMAINS OF ANXIETY AND MOOD OF THE UNIVERSITY OF WASHINGTON HEAD AND NECK CANCER QUESTIONNAIRE (UW-QOL V4) WITH THE CES-D AND HADS

Simon N. Rogers; B.P. Rajlawat; Janaki Goru; Derek Lowe; Gerry Humphris

Version 4 of the University of Washington Head and Neck Cancer Questionnaire (UW‐QOLv4) includes items on mood and anxiety. The aim of this study was to compare the responses to these single items with the Centre for Epidemiology Studies Depression Scale (CES‐D) and the Hospital Anxiety Depression Scale (HADS).


International Journal of Oncology | 2015

Trends and regional variation in the incidence of head and neck cancers in England: 2002 to 2011.

Caroline E. McCarthy; John K. Field; B.P. Rajlawat; Anne Field; Michael W. Marcus

Recent studies show an increased incidence of head and neck cancers worldwide. The present study evaluated the trend in the incidence of head and neck cancers in England during 2002-2011. Data were extracted from the database of Office for National Statistics. The study population was categorised according to age, residential area, gender and cancer sub-types. Overall trend in incidence of head and neck cancer and some subtypes were examined using Poisson regression models. In total, 71,457 head and neck cancers were registered in England between 2002 and 2011 and 68% of patients were males. Statistically significant increases in incidence of 27.0 and 32.4% were documented in males and females, respectively (p<0.001) with the largest increase in the 60+ age category. Potentially HPV-associated cancers, oral cavity cancers and laryngeal cancers increased by 47.1, 24.1 and 1.7% in males and 37.5, 25.5 and 7.7% in females, respectively (p<0.001). Regional differences were also noted with the highest incidence (18.0 and 17.0 per 100,000, respectively) in the North East and North West of England. Our results for England showed an increase in the incidence of both oral cavity and oropharyngeal cancer in both genders, whilst laryngeal cancer incidence remained stable.


British Dental Journal | 2017

The development and implementation of a biopsy safety strategy for oral medicine

D. J. Finn; B.P. Rajlawat; D. J. Holt; S. R. L. Adair; K. Kent; E. A. Field

The development and implementation of a biopsy safety strategy is described in this article. Analysis of previous adverse incidents relating to biopsies acted as a catalyst to review our biopsy pathway at Liverpool University Dental Hospital. Input from all staff involved enabled us to develop a biopsy safety strategy which was divided into five stages: preoperative assessment of patient and procedure, team briefings, biopsy surgical safety checklist, surgical removal and handling of biopsy specimens, and post-biopsy follow-up. It is hoped that other clinical teams will take the opportunity to review their own biopsy processes, in the light of our experience.


Innovait | 2013

Facial pain: trigeminal neuralgia

Francis O’Neill; B.P. Rajlawat

Trigeminal neuralgia (TN) is a debilitating condition characterised by attacks of sharp, shooting, severe pain in the orofacial region. It can be triggered by activities of daily living such as eating, speaking, washing the face, shaving and brushing teeth. It therefore has a significant impact on a patient’s social interaction, mood and well-being. Other causes for facial pain need to be effectively excluded prior to establishing a diagnosis of TN. It is important to establish a diagnosis promptly. Often patients can see many practitioners including their general dental practitioner, GP and various secondary referral practitioners before a diagnosis is made. This can add significantly to distress and delays treatment. This article describes the clinical features of TN, differential diagnosis, initial management options and presents guidance on referral to secondary care.


British Dental Journal | 2010

HARD TO SWALLOW

J. C. Steele; B.P. Rajlawat; E.A. Field

Sir, the majority of your readers will be aware of the ability of a certain proportion of the population to roll or fold their tongue. This is often a source of amusement and a useful party trick! Your readers may also wish to be made aware of a third sub-group with the ability to ‘swallow’ their tongue. Figure 1 shows a patient who was referred for a routine appointment to the Department of Oral Medicine at Liverpool University Dental Hospital. As part of the intra-oral examination, the patient was instructed to roll her tongue and touch the roof of her mouth in order for the ventral surface and fl oor of mouth to be examined effectively. To our astonishment and amazement, we were presented with a ‘tongue-less’ oral cavity that was momentarily disorientating. This is an oral physiological phenomenon that is rarely seen.


Oral Oncology | 2015

The management of oral epithelial dysplasia: The Liverpool algorithm

E.A. Field; Caroline E. McCarthy; Michael Ho; B.P. Rajlawat; D. Holt; Simon N. Rogers; Asterios Triantafyllou; John K. Field; Richard Shaw


Graefes Archive for Clinical and Experimental Ophthalmology | 2012

Ocular and oral grading of Mucous Membrane Pemphigoid

Graham M. B. Reeves; Marianne Lloyd; B.P. Rajlawat; Gillian L. Barker; E. Anne Field; Stephen B. Kaye


Oral Surgery | 2014

Warty dyskeratoma of the buccal mucosa

J. C. Steele; A.R. Dutton; Asterios Triantafyllou; B.P. Rajlawat

Collaboration


Dive into the B.P. Rajlawat's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar

E.A. Field

University of Liverpool

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Richard Shaw

University of Liverpool

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

J. C. Steele

University of Liverpool

View shared research outputs
Top Co-Authors

Avatar

Michael Ho

University of Liverpool

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

D. Holt

University of Liverpool

View shared research outputs
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge