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Dive into the research topics where B. Pieske is active.

Publication


Featured researches published by B. Pieske.


British Journal of Pharmacology | 2012

JTV519 (K201) reduces sarcoplasmic reticulum Ca2+ leak and improves diastolic function in vitro in murine and human non-failing myocardium

Michael Sacherer; Simon Sedej; Paulina Wakula; Markus Wallner; Ma Vos; Jens Kockskämper; P Stiegler; Michael Sereinigg; D. von Lewinski; Gudrun Antoons; B. Pieske; Frank R. Heinzel

BACKGROUND AND PURPOSE Ca2+ leak from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyR2s) contributes to cardiomyocyte dysfunction. RyR2 Ca2+ leak has been related to RyR2 phosphorylation. In these conditions, JTV519 (K201), a 1,4‐benzothiazepine derivative and multi‐channel blocker, stabilizes RyR2s and decrease SR Ca2+ leak. We investigated whether JTV519 stabilizes RyR2s without increasing RyR2 phosphorylation in mice and in non‐failing human myocardium and explored underlying mechanisms.


Cardiovascular Research | 2003

Stretch-elicited Na+/H+ exchanger activation: the autocrine/paracrine loop and its mechanical counterpart

Horacio E. Cingolani; Néstor G. Pérez; B. Pieske; Dirk von Lewinski; María C. Camilión de Hurtado

The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength after which occurs a slow force increase (SFR) that takes several minutes to fully develop. The SFR was detected in a wide variety of experimental preparations including isolated myocytes, papillary muscles and/or trabeculae, left ventricle strips of failing human myocardium, in vitro isovolumic and in vivo volume-loaded hearts. It was established that the initial increase in force is due to an increase in myofilament Ca2+ responsiveness, whereas the SFR results from an increase in the Ca2+ transient. However, the mechanism(s) for this increase in the Ca2+ transient has remained undefined until the proposal of Na+/H+ exchanger (NHE) activation by stretch. Studies in multicellular cardiac muscle preparations from cat, rabbit, rat and failing human heart have shown evidence that the stretch induces a rise in intracellular Na+ ([Na+]i) through NHE activation, which subsequently leads to an increase in Ca2+ transient via reverse-mode Na+/Ca2+ (NCX) exchange. These experimental data agree with a theoretical ionic model of cardiomyocytes that predicted an increased Na+ influx and a concurrent increase in Ca2+ entry through NCX as the cause of the SFR to muscle stretch. However, there are aspects that await definitive demonstration, and perhaps subjected to species-related differences like the possibility of an autocrine/paracrine loop involving angiotensin II and endothelin as the underlying mechanism for stretch-induced NHE activation leading to the rise in [Na+]i and reverse-mode NCX.


Frontiers in bioscience (Elite edition) | 2013

Relevance of stretch-induced phosphorylation of MAPK and p90rsk in human myocardium.

Anke Kockskämper; von Lewinski D; Danan Zhu; Jens Kockskämper; Mounir Khafaga; Albrecht Schmidt; Heiner Post; B. Pieske


Cardiovascular Research | 2014

P388Reduced pressure overload-induced myocardial remodeling in K201-treated mice with the R4496C cardiac ryanodine receptor mutation

Simon Sedej; M Matovina; Albrecht Schmidt; Senka Ljubojevic; Frank R. Heinzel; Sara Negri; Carlo Napolitano; M A Vos; Silvia G. Priori; B. Pieske


Cardiovascular Research | 2014

P680Na+/Ca2+ exchanger (NCX) function and diastolic Ca2+ leak in a model of heart failure with preserved ejection fraction

Uwe Primessnig; A. Hoell; Paulina Wakula; B. Pieske; Frank R. Heinzel


Journal of clinical and basic cardiology | 2012

Immunological Implications in Experimental Myocardial Ischaemia: MPO (Myeloperoxidase) Expression Is Differentially Regulated by Beta-Blockers, While CD80 Expression Remains Unaffected

Robert Gasser; Pätzold S; Holzwart E; Klemens Ablasser; Kraigher-Krainer E; Friehs I; Lewinski D; B. Pieske; Heinrich Mächler; Trantiner-Yates A; Tscheliessnig Kh; Harald Mangge; Porta S; Gasser S


Journal of clinical and basic cardiology | 2011

Effect of Betablockers on the Regulation of PDK (Pyruvate Dehydrogenase Kinase) Gene Expression in Both Normoxic and Hypoxic Myocardium

Holzwart E; Gasser S; Roessl U; Buehner A; Klemens Ablasser; Friehs I; B. Pieske; Heinrich Mächler; Yates A; Tscheliessnig Kh; Harald Mangge; Porta S; Robert Gasser


Intensivmedizin Und Notfallmedizin | 2011

„Cooling“ nach kardiopulmonaler Reanimation im Jahr 2011 : Indikationen und Durchführung (Leitthema)

D. von Lewinski; B. Pieske


Intensivmedizin Und Notfallmedizin | 2011

Cooling nach kardiopulmonaler Reanimation im Jahr 2011: Indikationen und Durchführung

D. von Lewinski; B. Pieske


Journal of clinical and basic cardiology | 2010

Shift from Adult to Fetal Metabolic Phenotype During Prolonged Experimental Myocardial Ischemia: A Study on the Effect of Beta Blockers upon Gene Expression of Transmembrane Glucose Transporters

S. Gasser; U. Roessl; E. Holzwart; Klemens Ablasser; I. Friehs; D. von Lewinski; B. Pieske; Heinrich Mächler; Trantiner-Yates A; Harald Mangge; Robert Gasser

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Albrecht Schmidt

Medical University of Graz

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Harald Mangge

Medical University of Graz

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Heinrich Mächler

Medical University of Graz

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Holzwart E

Medical University of Graz

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