D. von Lewinski | Researchain

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Featured researches published by D. von Lewinski.

British Journal of Pharmacology | 2012

JTV519 (K201) reduces sarcoplasmic reticulum Ca2+ leak and improves diastolic function in vitro in murine and human non-failing myocardium

Michael Sacherer; Simon Sedej; Paulina Wakula; Markus Wallner; Ma Vos; Jens Kockskämper; P Stiegler; Michael Sereinigg; D. von Lewinski; Gudrun Antoons; B. Pieske; Frank R. Heinzel

BACKGROUND AND PURPOSE Ca2+ leak from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyR2s) contributes to cardiomyocyte dysfunction. RyR2 Ca2+ leak has been related to RyR2 phosphorylation. In these conditions, JTV519 (K201), a 1,4‐benzothiazepine derivative and multi‐channel blocker, stabilizes RyR2s and decrease SR Ca2+ leak. We investigated whether JTV519 stabilizes RyR2s without increasing RyR2 phosphorylation in mice and in non‐failing human myocardium and explored underlying mechanisms.

Journal of Thrombosis and Haemostasis | 2017

Implementation of buffy-coat-derived pooled platelet concentrates for internal quality control of light transmission aggregometry: a proof of concept study

Florian Prüller; K. Rosskopf; Harald Mangge; Elisabeth Mahla; D. von Lewinski; E. C. Weiss; A. Riegler; D. Enko

Essentials In platelet function testing, standardized internal controls (IQC) are not commercially provided. Platelet function testing was performed daily on aliquoted pooled platelet concentrates. Pooled platelet concentrates showed stability for control purposes from Monday to Friday. Pooled platelet concentrates provide the necessary steadiness to serve as IQC material.

Herz | 2012

Fungal endocarditis of a bioprosthetic aortic valve

Markus Wallner; G. Steyer; R. Krause; C. Gstettner; D. von Lewinski

European Heart Journal | 2018

P6417Effects of snowfall and temperature on the incidence of over 18000 acute coronary syndrome cases

Klemens Ablasser; P Zechner; A Muster; V Taucher; Ewald Kolesnik; Nicolas Verheyen; Gabor G. Toth; Herwig Schuchlenz; D. von Lewinski

European Heart Journal | 2018

P2545Association analysis of air polution on acute coronary syndrome and myocardial infarction in a large cohort

V Taucher; Peter Rainer; Klemens Ablasser; T M Berghaus; P Zechner; Wolfgang Weihs; A Muster; D. von Lewinski

European Heart Journal | 2017

P5257The anti-cancer tyrosine kinase inhibitor sorafenib reduces cardiac contractile force by reducing cardiomyocyte calcium transient amplitude

C. Schneider; Markus Wallner; Martin Pichler; D. von Lewinski; Simon Sedej; Peter Rainer

European Heart Journal | 2017

P3560Amino acids kynurenine and quinolinic acid and target organ damage in hypertensive patients - novel insights from the styrian hypertension study

Nicolas Verheyen; M.G. Gaksch; A.M. Andreas; M.G. Gruebler; Christopher Trummer; Verena Schwetz; M.P. Pandis; Klemens Ablasser; Ewald Kolesnik; D. von Lewinski; Helmut Brussee; W.M. Maerz; Andreas Tomaschitz; Stefan Pilz

European Heart Journal | 2017

3116Hypothermia impairs platelet-function in resuscitated patients after myocardial infarction

D. von Lewinski; O.L. Milke; L. Bis; Friedrich M. Fruhwald; Daniel Scherr; Siegfried Altmanninger-Sock; Harald Sourij; S. Paetzold; Jolanta M. Siller-Matula; F. Prueller

European Heart Journal | 2017