B. Rigo

Decarboxylation of pyroglutamic acids with P2O5/CH3SO3H: a general synthesis of 5-aryl-2-pyrrolidinones

Abstract Treatment of pyroglutamic acids with acyl-activating reagents (P 2 O 5 /CH 3 SO 3 H, PPE ...), possibly in the presence of triethylamine, yields acyl iminium salts, that can react in-situ with aromatic compounds to give the corresponding 5-aryl-2-pyrrolidinones with good yields.

Reaction of trimethylsilyl derivatives with Meldrum's acid : A new and easy monofunctionalization of malonic acid

Abstract Treatment of Meldrums acid with silylated derivatives (amines, lactams or alcohols) yields very easily monofunctionalized malonic silyl esters. Hydrolysis of these silyl esters leads to the corresponding monoacids with a very good yield.

Electrochemical synthesis of the vinylogs of N-acyl N,O-acetals and their reactivity

Abstract Vinylogs of N-acyl N,O-acetals are formed in good yields by anodic oxidation, in methanol or water, of β-enaminoesters derived from pyroglutamic acid. These new acetals react easily with nucleophiles or silylated amines.