Pascal Cauliez

Reaction of trimethylsilyl derivatives with Meldrum's acid : A new and easy monofunctionalization of malonic acid

Abstract Treatment of Meldrums acid with silylated derivatives (amines, lactams or alcohols) yields very easily monofunctionalized malonic silyl esters. Hydrolysis of these silyl esters leads to the corresponding monoacids with a very good yield.

Reaction of Hexamethyldisilazane with Diacylhydrazines : An Easy 1,3,4-Oxadiazole Synthesis

Abstract The reaction of diacylhydrazines with hexamethyldisilazane in the presence of tetrabutylammonium fluoride as catalyst results in cyclisation to give 1,3,4-oxadiazoles in good yield.

Disilylated Compounds as Precursors of Heterocycles: A New and Easy Oxadiazole Synthesis

Abstract Silyl diacylhydtazines have been synthesized. When they are treated with 3 slight amount of a uariety of catalyst (nucleophiles, F, true or Lewis acids, Pd, Pt.), 1,3,4-oxadiazoles are obtained. This cyclization can be performed in one step by using hexamethyldisilazane or dimethyldichlorosilane as the silylation agent.

Electrochemical synthesis of the vinylogs of N-acyl N,O-acetals and their reactivity

Abstract Vinylogs of N-acyl N,O-acetals are formed in good yields by anodic oxidation, in methanol or water, of β-enaminoesters derived from pyroglutamic acid. These new acetals react easily with nucleophiles or silylated amines.