B.S.P. Anil Kumar

Recyclable Ru/C catalyzed oxidative cyanation of tertiary amines with TBHP

The recyclable Ru/C catalyzed oxidative α-cyanation of tertiary amines with ethyl cyanoformate by using TBHP as an oxidant under ambient conditions has been developed. Utilizing this protocol, α-aminonitrile derivatives were synthesized in good to excellent yields with high selectivity. The cyanide source (ethyl cyanoformate) employed herein was relatively cheap and less toxic, which would be beneficial. The catalyst was also inexpensive and commercially available as well as recyclable up to four cycles, without significant loss of its catalytic activity.

Synthesis of β-hydroxy-1,4-disubstituted-1,2,3-triazoles catalyzed by copper ferrite nanoparticles in tap water using click chemistry

A novel one pot synthesis of β-hydroxy-1,4-disubstituted-1,2,3-triazoles has been developed by using CuFe2O4 magnetic nanoparticles. This methodology involves additive free, easily recyclable catalyst in water medium and avoids the handling of organic azides as they are generated in situ.

Ru/C: a simple heterogeneous catalyst for the amination of azoles under ligand free conditions

A ligand free Ru/C-catalyzed amination of 2-halo azoles with a broad scope of aminating reagents has been developed. A variety of 2-aminoazole derivatives were synthesized in moderate to good yields by utilizing this protocol. The methodology is operationally simple and not sensitive to air and moisture. It provides potentially useful products by using an inexpensive and recyclable catalytic system under ligand free conditions without significant loss of its catalytic activity up to four cycles.

A novel one pot four-component reaction for the efficient synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-3′-carboxylate and trifluoromethylated spiro[indole-3,4′-pyrano[2,3-c]pyrazole] derivatives using recyclable PEG-400

A novel, simple and efficient synthetic protocol has been developed for the synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-3′-carboxylate and trifluoromethylated spiro[indole-3,4′-pyrano[2,3-c]pyrazole] derivatives via a one pot, four-component reaction using recyclable polyethylene glycol (PEG-400). This new protocol produces novel spiro pyranopyrazole derivatives in good to excellent yields, with operational simplicity and recycling of PEG-400. The remarkable features of this methodology are high yields, an easy work-up process, and a greener method that avoids toxic catalyst and hazardous solvents.