V. Prakash Reddy

Recyclable Ru/C catalyzed oxidative cyanation of tertiary amines with TBHP

The recyclable Ru/C catalyzed oxidative α-cyanation of tertiary amines with ethyl cyanoformate by using TBHP as an oxidant under ambient conditions has been developed. Utilizing this protocol, α-aminonitrile derivatives were synthesized in good to excellent yields with high selectivity. The cyanide source (ethyl cyanoformate) employed herein was relatively cheap and less toxic, which would be beneficial. The catalyst was also inexpensive and commercially available as well as recyclable up to four cycles, without significant loss of its catalytic activity.

Ru/C: a simple heterogeneous catalyst for the amination of azoles under ligand free conditions

A ligand free Ru/C-catalyzed amination of 2-halo azoles with a broad scope of aminating reagents has been developed. A variety of 2-aminoazole derivatives were synthesized in moderate to good yields by utilizing this protocol. The methodology is operationally simple and not sensitive to air and moisture. It provides potentially useful products by using an inexpensive and recyclable catalytic system under ligand free conditions without significant loss of its catalytic activity up to four cycles.

Ru-Catalyzed highly site-selective C–H bond arylation of 9-(pyrimidin-2-yl)-9H-carbazole

We describe here an efficient ruthenium-catalyzed C–H bond ortho-arylation of 9-(pyrimidin-2-yl)-9H-carbazole by using boronic acids. This methodology exhibits excellent and high site-selectivity, functional group tolerance and was found to give the desired product in moderate to good yields.