B. S. Sudha

Synthesis, spectral characterization and antihaemostatic activity of 1,2,4-triazoles incorporating 1,2,4-triazine rings

A simple and high yielding method for the integration of a 1,2,4-triazole ring with 1,2,4-triazine-5-one (4a-j) has been developed starting from 3-arylsydnones (1a-d). The structures were proved by their spectral data and screened for antihaemostatic activity.

Synthesis and Pharmacological Evaluation of 1,5-Benzothiazepine Derivatives

A simple method for the synthesis of 1,5-benzothiazepines integrated with 5-methyl-2-oxo-3-phenyl-Δ 4-1,3,4-oxadiazoles in 75–95% yield is devised. A comparison of microwave-accelerated reaction with conventional heating is also illustrated. Structures of all the newly synthesised compounds were characterised by physical, analytical and spectral (UV, IR, 1H NMR, and MS) data. Title compounds were screened for their antimicrobial, anticonvulsant, anti-inflammatory, and diuretic activities.

Photochemical synthesis and antimicrobial activity of dihydrobenzofuranols from 2-alkoxy substituted benzophenones and ethyl-2-aroyl aryloxy acetates

Upon UV irradiation 2-alkoxy substituted benzophenones 2a–f and ethyl-2-aroyl aryloxy acetates 7a–c, in acetonitrile under went intramolecular δ hydrogen abstraction and led to synthesis of solely dihydrobenzofuranols 6a–f and 11a–c in excellent yield with potent antimicrobial activity.