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B. Singer

Lawrence Berkeley National Laboratory

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Encyclopedia of Biological Chemistry | 2004

DNA Damage: Alkylation

Anton B. Guliaev; B. Singer

Author(s): Guliaev, Anton B.; Singer, B. | Abstract: Alkylation is the reaction of electrophilic chemical compounds or alkylating agents with the nucleophilic centers in organic macromolecules. Alkylating agents include a large variety of chemicals, some of which are potent mutagens or carcinogens.

DNA Repair | 2005

The p-benzoquinone DNA adducts derived from benzene are highly mutagenic.

Zhongwen Xie; Yangbin Zhang; Anton B. Guliaev; Huiyun Shen; Bo Hang; B. Singer; Zhigang Wang

Nucleic Acids Research | 2002

Structural insights by molecular dynamics simulations into differential repair efficiency for ethano‐A versus etheno‐A adducts by the human alkylpurine‐DNA N‐glycosylase

Anton B. Guliaev; Bo Hang; B. Singer

Nucleic Acids Research | 2004

Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene‐derived DNA adduct, pBQ‐C

Anton B. Guliaev; Bo Hang; B. Singer

Biochemistry | 2001

15-mer DNA duplexes containing an abasic site are thermodynamically more stable with adjacent purines than with pyrimidines.

Jianos Sagi; Anton B. Guliaev; B. Singer

Mutation Research | 2003

Miscoding properties of 1,N6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea

Bo Hang; Ahmed Chenna; Anton B. Guliaev; B. Singer

DNA Repair | 2004

Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts

Anton B. Guliaev; B. Singer; Bo Hang

Carcinogenesis | 2000

Sequence-dependent conformational perturbation in DNA duplexes containing an ϵA•T mismatch using molecular dynamics simulation

Anton B. Guliaev; János Sági; B. Singer

Chemical Research in Toxicology | 2000

Differential destabilization of the DNA oligonucleotide double helix by a T.G mismatch, 3,N(4)-ethenocytosine, 3,N(4)-ethanocytosine, or an 8-(hydroxymethyl)-3,N(4)-ethenocytosine adduct incorporated into the same sequence contexts.

Janos Sagi; Alex Perry; Bo Hang; B. Singer

Chemical Research in Toxicology | 2000

Synthesis of 8-(hydroxymethyl)-3,N(4)-etheno-2'-deoxycytidine, a potential carcinogenic glycidaldehyde adduct, and its site-specific incorporation into DNA oligonucleotides.

Ahmed Chenna; and Alex Perry; B. Singer

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Anton B. Guliaev

Lawrence Berkeley National Laboratory

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Bo Hang

Lawrence Berkeley National Laboratory

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Ahmed Chenna

Lawrence Berkeley National Laboratory

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Huiyun Shen

University of Kentucky

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Yangbin Zhang

University of Kentucky

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Zhigang Wang

University of Kentucky

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Zhongwen Xie

University of Kentucky

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