B. V. Ashalatha

Synthesis and Characterization of Some Novel 3-Bromo-2-acetylthiophene Chalcones and Biological Evaluation of Their Ethyl-4-(3-bromothien-2-yl)-2-oxo-6-(aryl)cyclohex-3-ene-1-carboxylate Derivatives

Novel chalcones 1-(3-bromothien-2-yl)-3-(aryl)prop-2-en-1-ones derived from 3-bromo-2-acetylthiophene and their cyclization product with ethylacetoacetate such as 4-(3-bromothien-2-yl)-2-oxo-6-(aryl)cyclohex-3-ene-1-carboxylate derivatives were synthesized and studied by X-ray, analytical, and spectral methods. Compounds were screened for their anti-inflammatory, analgesic, and antimicrobial activities. The compound ethyl-4-(3-bromothien-2-yl)-2-oxo-6-(4-propoxyphenyl) cyclohex-3-ene-1-carboxylate 5c exhibited promising anti-inflammatory, analgesic and antibacterial activities.

Ethyl 4-(3-bromo-2-thien­yl)-2-oxo-6-phenyl­cyclo­hex-3-ene-1-carboxyl­ate

The title compound, C19H17BrO3S, crystallizes with two molecules in the asymmetric unit. The methyl group of one molecule is disordered approximately equally over two positions. The dihedral angles between the thiophene and phenyl groups are 68.5 (2) and 67.5 (2)° in the two molecules.

Synthesis of Some New 4-{2-[(Aryl)amino]-1,3-thiazol4-yl}benzene-1,2-diols as Possible Antibacterial and Antifungal Agents

Some new 4-{2-[(aryl) amino]-1,3-thiazol-4-yl}benzene-1,2-diols are prepared and characterized by spectral analysis. The newly prepared compounds are studied for their antibacterial and antifungal activity. Interestingly, almost all the compounds are found to possess promising antibacterial and antifungal activity against all tested microorganisms.

1-(3-Bromo-2-thienyl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one

The title compound, C18H13BrO2S, is chiral due to the twist of the naphthalene and thienyl rings about the chalcone backbone dihedral angle = 17.75 (10)degrees]. There are weak C - H center dot center dot center dot O interactions which link the molecules into chains in the b direction.

1-(3-bromo-2-thienyl)-3-(4-butoxyphenyl)prop-2-en-1-one

The title compound, C17H17BrO2S, forms centrosymmetric dimers linked by weak C - H center dot center dot center dot O hydrogen bonding generating an R-2(10) ring. The dihedral angle between the thienyl and benzene rings is 5.79 ( 10)degrees.

5-Bromo­pyrimidin-2(1H)-one

The geometric parameters of the title compound, C4H3BrN2O, are in the usual ranges. The crystal packing is characterized by N-H center dot center dot center dot N and C-H center dot center dot center dot O hydrogen bonds and short O center dot center dot center dot Br contacts.

Synthesis and Biological Activity of Novel 4-/5-/6-/7-Nitro-N ′-(4-Aryl-1,3-Thiazol-2-yl)1H-Indole-2-Carbohydrazide Derivatives

New 4-/5-/6-/7-nitro-N′-(4-aryl-1,3-thiazol-2-yl)-1H-indole-2-carbohydrazides (4a–t) were prepared by treating respective nitroindole thiosemicarbazide with aromatic acylbromides. The newly synthesized compounds were characterized by analytical and spectral data. The compounds were also screened for antifungal and antibacterial activity. Some of the compounds exhibited promising antimicrobial activity.

(2E)-3-(1,3-Benzodioxol-5-yl)-1-(3-bromo-2-thien-yl)prop-2-en-1-one.

In the title molecule, C14H9BrO3S, the the prop-2-en-1-one (enone) fragment is close to planar [C—C—C—O = 2.5 (7)°] and it subtends dihedral angles of 12.5 (3) and 5.3 (4)° with respect to the thiophene and benzene rings, respectively. The dihedral angle between the aromatic ring systems is 12.60 (18)°. Two C—H⋯O interactions help to consolidate the non-centrosymmetic crystal packing, which features undulating (100) sheets incorporating C(11) and C(12) chain motifs.

Synthesis of Some New 4-(2-Chloropyridin-4-yl)-N-Aryl-1,3-Thiazol-2-Amine Derivatives as Possible Antifungal and Antibacterial Agents

Novel 4-(2-chloropyridin-4-yl)-N-aryl-1,3-thiazol-2-amines have been prepared by reacting (4-bromoacetyl)-2-chloropyridine with thiourea and substituted thioureas. The newly synthesized compounds have been characterized by analytical and spectral data. All the compounds have been screened for their antifungal and antibacterial activities. Almost all the compounds were found to possess excellent antifungal and antibacterial activities.

Synthesis of 4-, 5-, 6- and 7-nitroindole-2-methanols and 4-, 5-, 6- and 7-nitroindole-2-carbaldehydes

The synthesis of 4-, 5-, 6- and 7-nitroindole-2-methanols and the corresponding 2-aldehydes is described. The nitroindole-2-methanols were prepared by the reduction of ethyl 4-, 5-, 6- and 7-nitroindole-2-carboxylates with sodium borohydride in methanol/tetrahydrofuran. 4-, 5-, 6- and 7-Nitroindole-2-aldehydes were prepared from the nitroindole-2-methanols using PCC (pyridinium chlorochromate) and with chromium trioxide–pyridine prepared in situ.