Babette-Yvonne Koegel
Grünenthal GmbH
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Publication
Featured researches published by Babette-Yvonne Koegel.
Bioorganic & Medicinal Chemistry Letters | 2014
HyungChul Ryu; Sejin Seo; Myeong Seop Kim; Mi-Yeon Kim; Ho Shin Kim; Jihyae Ann; Phuong-Thao Tran; Van-Hai Hoang; Jieun Byun; Minghua Cui; Karam Son; Pankaz Kumar Sharma; Sun Choi; Peter M. Blumberg; Robert Frank-Foltyn; Gregor Bahrenberg; Babette-Yvonne Koegel; Thomas Christoph; Sven Frormann; Jeewoo Lee
A series of 2-aryl pyridine C-region derivatives of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were investigated as hTRPV1 antagonists. Multiple compounds showed highly potent TRPV1 antagonism toward capsaicin comparable to previous lead 7. Among them, compound 9 demonstrated anti-allodynia in a mouse neuropathic pain model and blocked capsaicin-induced hypothermia in a dose-dependent manner. Docking analysis of 9 with our hTRPV1 homology model provided insight into its specific binding mode.
Archive | 2009
Claudia Hinze; Otto Aulenbacher; Bernd Sundermann; Stefan Oberboersch; Elmar Friderichs; Werner Englberger; Babette-Yvonne Koegel; Klaus Linz; Hans Schick; Helmut Sonnenschein; Birgitta Henkel; Valerie Sarah Rose; Michael Jonathan Lipkin
Archive | 2002
Bernd Sundermann; Hagen-Heinrich Hennies; Werner Englberger; Babette-Yvonne Koegel
Archive | 2000
Bernd Sundermann; Babette-Yvonne Koegel; Helmut Buschmann
Archive | 1997
Helmut Heinrich Dipl Buschmann; Wolfgang Werner Alfred Strassburger; Elmar Josef Friderichs; Babette-Yvonne Koegel
Archive | 2007
Elmar Friderichs; Babette-Yvonne Koegel; Klaus Linz
Archive | 2003
Bernd Sundermann; Hagen-Heinrich Hennies; Werner Englberger; Babette-Yvonne Koegel
Archive | 2003
Elmar Josef Friderichs; Bernd Sundermann; Claudia Hinze; Babette-Yvonne Koegel
Archive | 2011
Claudia Hinze; Otto Aulenbacher; Bernd Sundermann; Stefan Oberboersch; Elmar Friderichs; Werner Englberger; Babette-Yvonne Koegel; Klaus Linz; Hans Schick; Helmut Sonnenschein; Birgitta Henkel; Valerie Sarah Rose; Michael Jonathan Lipkin
Archive | 2010
Klaus Schiene; Guenther Haase; Babette-Yvonne Koegel; Elmar Friderichs; Ulrich Jahnel
