Bajram Zeqiri

A novel sensor for monitoring acoustic cavitation. Part I: Concept, theory, and prototype development

This paper describes a new concept for an ultrasonic cavitation sensor designed specifically for monitoring acoustic emissions generated by small microbubbles when driven by an applied acoustic field. Its novel features include a hollow, open-ended, cylindrical shape, with the sensor being a right circular cylinder of height 32 mm and external diameter 38 mm. The internal diameter of the sensor is 30 mm; its inner surface is fabricated from a 110 /spl mu/m layer of piezoelectrically active film whose measurement bandwidth is sufficient to enable acoustic emissions up to and beyond 10 MHz to be monitored. When in use, the sensor is immersed within the liquid test medium and high frequency (megahertz) acoustic emissions occurring within the hollow body of the sensor are monitored. In order to shield the sensor response from events occurring outside the cylinder, the outer surface of the sensor cylinder is encapsulated within a special 4 mm thick polyurethane-based cavitation shield with acoustic properties specifically developed to be minimally perturbing to the 40 kHz applied acoustic field but attenuating to ultrasound generated at megahertz frequencies (plane-wave transmission loss >30 dB at 1 MHz). This paper introduces the rationale behind the new sensor, describing details of its construction and the materials formulation program undertaken to develop the cavitation shield.

The influence of waveform distortion on hydrophone spatial‐averaging corrections—Theory and measurement

A significant source of error in measurements of the acoustic output of medical ultrasonic equipment can arise from spatial averaging of the acoustic pressure over the active area of the hydrophone. Although criteria exist that quantify the maximum permissible effective hydrophone diameter, these are frequently violated for measurements on medical diagnostic systems, even for 0.4‐mm‐diam hydrophones that currently constitute the smallest commercially available device. In such circumstances, corrections have to be applied to the measured acoustical parameters. In the past, these correction procedures have been based on idealized models of the transducer pressure field distribution and have not taken account of finite amplitude effects which lead to nonlinearly distorted waveforms. This paper presents a systematic study of the influence of nonlinear distortion on spatial‐averaging corrections. A 5‐MHz focused transducer has been used to generate a range of acoustic waveforms suffering from varying degrees o...

A NEW ANECHOIC MATERIAL FOR MEDICAL ULTRASONIC APPLICATIONS

This paper describes a newly developed material with acoustic properties that make it ideal for applications as radiation force balance-absorbing targets. The material is now commercially available from National Physical Laboratory (NPL) and is based on a polyurethane rubber. It exhibits an echo reduction of 45 dB, and single-pass transmission loss of 30 dB, both determined at an acoustic frequency of 1 MHz. The composition and structure of the new NPL absorber are presented, along with values for the frequency and temperature variation of the echo reduction and transmission loss. Over the frequency range 1 to 10 MHz, its acoustic properties comply with the requirements for force balance-absorbing targets specified in IEC 61161.

Validated ultrasonic power measurements up to 20 w

A project has been completed to develop reference methods for the measurement of ultrasonic power with a validated measurement uncertainty of < 7% at power levels of 1 to 20 W over the frequency range 1 to 3 MHz of collimated beams. The project is the result of collaborative research between the Physikalisch-Technische Bundesanstalt, Germany (PTB, DE), the National Physical Laboratory, UK (NPL, UK) and the Netherlands Organisation for Applied Scientific Research, Prevention and Health (TNO-PG, NL). The work has been undertaken under the 4th Framework Programme of the European Community (EC). Primary standard designs of radiation force balances based on both absorbing and reflecting targets have been constructed. To avoid heating effects, the measurements should be done relatively quickly (10 to 20 s). The methods have been validated using ultrasound (US) transducers that demonstrated an adequate short and long-term stability; a method to detect cavitation based on monitoring the acoustic signals produced by bubble oscillation and collapse has been confirmed. It has been shown that only the detection of the subharmonic can be used in practice as cavitation detector. Different procedures for obtaining degassed water have been investigated. A method showing significant promise to be used in a clinical or manufacturers environment involves the addition of sodium sulphite (Na2SO3). During the validation process, commercially available radiation force balances and ultrasonic physiotherapy devices have also been evaluated. Limitations of current measurement methods and practices, including power measurements made on transducers exhibiting a diverging beam, have been identified. It has been shown that a reflecting target is not appropriate to measure powers of transducers with a ka-value < 30. Based on beam shape and target distance, it has been shown also that proper power measurements using a 45 degrees convex-conical reflecting target can never be performed for transducers with a ka-value < 17.4.

Toward a reference ultrasonic cavitation vessel: Part 2-investigating the spatial variation and acoustic pressure threshold of inertial cavitation in a 25 kHz ultrasound field

As part of an ongoing project to establish a reference facility for acoustic cavitation at the National Physical Laboratory (NPL), carefully controlled studies on a 25 kHz, 1.8 kW cylindrical vessel are described. Using a patented high-frequency acoustic emission detection method and a sonar hydrophone, results are presented of the spatial variation of inertial acoustic cavitation with increasing peak-negative pressure. Results show that at low operating levels, inertial acoustic cavitation is restricted to, and is strongly localized on, the vessel axis. At intermediate power settings, inertial acoustic cavitation also occurs close to the vessel walls, and at higher settings, a complex spatial variation is seen that is not apparent in measurements of the 25 kHz driving field alone. At selected vessel locations, a systematic investigation of the inertial cavitation threshold is described. This was carried out by making simultaneous measurements of the peak-negative pressures leading to inertial cavitation and the resultant MHz-frequency emissions, and indicates an inertial cavitation threshold of 101 kPa plusmn 14% (estimated expanded uncertainty). However, an intermediate threshold at 84 kPa plusmn 14% (estimated expanded uncertainty) is also seen. The results are discussed alongside theoretical predictions and recent experimental findings.

A strategy for the development and standardisation of measurement methods for high power/cavitating ultrasonic fields : review of high power field measurement techniques

This review was compiled as part of a project to formulate a UK strategy for the development and standardisation of measurement methods for high power/cavitating ultrasonic fields. It reviews the scientific literature relating to various methods of measuring high power fields which have been developed for application in health care, sonochemistry and industrial ultrasonics, and compares these methods in terms of attributes such as spatial resolution, bandwidth and sensitivity.

Primary calibration of membrane hydrophones in the frequency range 0.5 MHz to 60 MHz

A laser interferometer designed to measure acoustic displacements at megahertz frequencies, which has been the basis of a primary standard for the calibration of ultrasonic hydrophones for over ten years, is described. The interferometer is of the Michelson type and is designed to measure the acoustic particle displacement by sensing the movement of a thin plastic membrane placed in the field of an ultrasonic transducer. The acoustic pressure is derived from the measurement of displacement and the hydrophone is calibrated by substituting it for the pellicle. Various sources of uncertainty are described, including acoustooptic corrections, the frequency response of the interferometer, the acoustic properties of the thin membrane, and the lack of ideal plane-wave conditions. Highest calibration accuracy is achievable for membrane hydrophones, with a relative standard uncertainty, for a confidence level of 95%, of 0.040 at 0.5 MHz, 0.035 from 1 MHz to 7 MHz, 0.046 at 20 MHz and increasing to 0.250 at 60 MHz. The dissemination of the primary standard calibration method, which uses membrane hydrophones as secondary standards, is also described. These hydrophones are shown to have predictable performance properties and long-term stability, making them ideal secondary standards and choice as gold-standard reference devices worldwide.

Measurement and testing of the acoustic properties of materials: a review

A review is presented of methods of measurement for a range of key acoustic properties of materials, spanning three application areas: airborne sound, underwater acoustics and ultrasound. The acoustic properties considered, primarily transmission loss (damping) and echo-reduction, are specifically important to the end application of any material. The state-of-the-art in measurement and likely future challenges are described in detail.

REFERENCE CHARACTERISATION OF SOUND SPEED AND ATTENUATION OF THE IEC AGAR-BASED TISSUE-MIMICKING MATERIAL UP TO A FREQUENCY OF 60 MHz

To support the development of clinical applications of high-frequency ultrasound, appropriate tissue-mimicking materials (TMMs) are required whose acoustic properties have been measured using validated techniques. This paper describes the characterisation of the sound speed (phase velocity) and attenuation coefficient of the International Electrotechnical Commission (IEC) agar-based TMM over the frequency range 1 to 60 MHz. Measurements implemented a broadband through-transmission substitution immersion technique over two overlapping frequency ranges, with co-axially aligned 50 MHz centre-frequency transducers employed for characterisation above 15 MHz. In keeping with usual practice employed within the technical literature, thin acoustic windows (membranes) made of 12-μm-thick Mylar protected the TMM from water damage. Various important sources of uncertainty that could compromise measurement accuracy have been identified and evaluated through a combination of experimental studies and modelling. These include TMM sample thickness, measured both manually and acoustically, and the influence of interfacial losses that, even for thin protective membranes, are significant at the frequencies of interest. In agreement with previous reports, the attenuation coefficient of the IEC TMM exhibited non-linear frequency dependence, particularly above 20 MHz, yielding a value of 0.93 ± 0.04 dB cm(-1) MHz(-1) at 60 MHz, derived at 21 ± 0.5°C. For the first time, phase velocity, measured with an estimated uncertainty of ±3.1 m s(-1), has been found to be dispersive over this extended frequency range, increasing from 1541 m s(-1) at 1 MHz to 1547 m s(-1) at 60 MHz. This work will help standardise acoustic property measurements, and establishes a reference measurement capability for TMMs underpinning clinical applications at elevated frequencies.

Errors in attenuation measurements due to nonlinear propagation effects

An investigation into the influence of finite amplitude distortion on narrow‐band ultrasonic attenuation measurements is described. Measurements have been made using a through‐transmission substitution technique in the nonlinear field of a 5‐MHz plane‐piston transducer driven under tone‐burst conditions. Various transducer excitation levels were used to generate a range of shock parameters σ at the position of the measuring hydrophone up to a maximum of 3. The influence of the resulting loss in amplitude at the fundamental frequency has been studied by measuring the transmission properties of reference attenuators consisting of Dow Corning‐710 fluid‐filled cells of various thickness. The presence of nonlinear distortion in the acoustic waveform produces overestimates of the measured transmission coefficients. The magnitude of the error has been shown to depend on the value of σ, the small signal transmission loss of the sample and its position in the acoustic field. In some situations, the error was as hi...