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Dive into the research topics where Balekudru Devadas is active.

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Featured researches published by Balekudru Devadas.


Bioorganic & Medicinal Chemistry Letters | 1997

Replacements for lysine in l-seryl-l-lysyl dipeptide amide inhibitors of candida albicans myristoyl-CoA:protein N-myristoyltransferase

David L. Brown; Balekudru Devadas; Hwang-Fun Lu; Srinivasan Nagarajan; Mark E. Zupec; Sandra K. Freeman; Charles A. McWherter; Daniel P. Getman; James A. Sikorski

Abstract A survey of potential cyclic and acyclic lysine replacements in known l -seryl- l -lysyl dipeptide inhibitors of C. albicans NMT identified the thioether 16 and glycinamide 18 as submicromolar inhibitors of C. albicans NMT, which retained good selectivity over the human enzyme. All of the heterocyclic lysine mimetics that were examined exhibited dramatically weaker affinity with the fungal enzyme.


Synthetic Communications | 1995

Syntheses of Novel 3-Substituted-2′-deoxy-3-deazauridine Nucleosides

Balekudru Devadas; Thomas E. Rogers; Steven H. Gray

Abstract Syntheses of novel 3-ethynyl (8), 3-vinyl (10) and 3-acetoxy (13)-2′-deoxy-3-deazauridine analogs starting from the protected 2′-deoxy-3-deazauridine derivative 4 are described.


Archive | 1998

Substituted benzopyran derivatives for the treatment of inflammation

Jeffery S. Carter; Mark G. Obukowicz; Balekudru Devadas; John J. Talley; David L. Brown; Matthew J. Graneto; Stephen R. Bertenshaw; Donald J. Rogier; Srinivasan Nagarajan; Cathleen E Hanau; Susan J. Hartmann; Cindy L Ludwig; Suzanne Metz


Archive | 1999

Substituted benzopyran analogs for the treatment of inflammation

Jeffery S. Carter; Mark G. Obukowicz; Balekudru Devadas; John J. Talley; David L. Brown; Matthew J. Graneto; Stephen R. Bertenshaw; Donald J. Rogier; Srinivasan Nagarajan; Cathleen E Hanau; Susan J. Hartmann; Cindy L Ludwig; Suzanne Metz; Donald E. Korte


Archive | 1996

Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors

John J. Talley; James A. Sikorski; Bryan H. Norman; Roland S. Rogers; Balekudru Devadas; Matthew J. Graneto; Jeffery S. Carter


Biopolymers | 1997

Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.

James A. Sikorski; Balekudru Devadas; Mark E. Zupec; Sandra K. Freeman; David L. Brown; Hwang-Fun Lu; Srinivasan Nagarajan; Pramod P. Mehta; Arlene C. Wade; Nandini S. Kishore; Martin L. Bryant; Daniel P. Getman; C A McWherter; Jeffrey I. Gordon


Archive | 1996

Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Daniel P. Getman; Gary A. DeCrescenzo; John N. Freskos; Michael L. Vazquez; James A. Sikorski; Balekudru Devadas; Srinivasan Nagarajan; David L. Brown; Joseph J. McDonald


Archive | 1996

Substituted oxazoles for the treatment of inflammation

John J. Talley; Stephen R. Bertenshaw; Donald J. Rogier; Matthew J. Graneto; David L. Brown; Balekudru Devadas; L U Hwang-fun; James A. Sikorski


Archive | 1996

Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors

Daniel P. Getman; Gary A. DeCrescenzo; John N. Freskos; Michael L. Vazquez; James A. Sikorski; Balekudru Devadas; Srinivasan Nagarajan; Joseph J. McDonald


Archive | 1996

Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors

James A. Sikorski; Daniel P. Getman; Gary A. DeCrescenzo; Balekudru Devadas; John N. Freskos; Hwang-Fun Lu; Joseph J. McDonald

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C A McWherter

Washington University in St. Louis

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Jeffrey I. Gordon

Washington University in St. Louis

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