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Barbara Dalie

Schering-Plough

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Featured researches published by Barbara Dalie.

FEBS Letters | 1997

Purification of ADAM 10 from bovine spleen as a TNFα convertase

Charles A. Lunn; Xuedong Fan; Barbara Dalie; Kenneth Miller; Paul J. Zavodny; Satwant K. Narula; Daniel Lundell

We have purified a protease with characteristics of TNFα convertase from bovine spleen membranes. Peptide sequencing of the purified protein identified it as ADAM 10 (Genbank accession no. Z21961). This metalloprotease cleaves a recombinant proTNFα substrate to mature TNFα, and can cleave a synthetic peptide substrate to yield the mature TNFα amino terminus in vitro. The enzyme is sensitive to a hydroxamate inhibitor of MMPs, but insensitive to phosphoramidon. In addition, cloned ADAM 10 mediates proTNFα processing in a processing‐incompetent cell line.

Archive | 1995

Humanized monoclonal antibodies against human interleukin-4

Barbara Dalie; Kenneth Miller; Nicholas J. Murgolo; Stephen Tindall

Archive | 1993

Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4

Barbara Dalie; Hung V. Le; Kenneth Miller; Nicholas J. Murgolo; Hanh Nguyen; Stephen Tindall; Paul J. Zavodny

Protein Expression and Purification | 1997

Expression, purification, and characterization of an activated cytokine-suppressive anti-inflammatory drug-binding protein 2 (CSBP2) kinase from baculovirus-infected insect cells.

Xiao-Yan Cai; Mary Shanahan; Kenneth Miller; Carl Gommoll; Dan Lundell; Paul J. Zavodny; Barbara Dalie

Archive | 2002

Mammalian TNF-alpha convertases

Barbara Dalie; Xuedong Fan; Daniel Lundell; Charles A. Lunn; Jimmy C. Tan; Paul J. Zavodny

Protein Expression and Purification | 1995

Expression and purification of two recombinant sterol-carrier proteins: SCPX and SCP2.

D.J. Manfra; C.L. Baum; E. Reschley; Daniel Lundell; Paul J. Zavodny; Barbara Dalie

Archive | 2006

Nucleic acids encoding human TNF-α convertase

Barbara Dalie; Xuedong Fan; Daniel Lundell; Charles A. Lunn; Jimmy C. Tan; Paul J. Zavodny

Archive | 1999

MAMMALIAN TNF--g(a) CONVERTASES

Barbara Dalie; Xuedong Fan; Daniel Lundell; Charles A. Lunn; Jimmy C. Tan; Paul J. Zavodny

Archive | 1997

Mammalian TNF-α convertases

Barbara Dalie; Xuedong Fan; Daniel Lundell; Charles A. Lunn; Jimmy C. Tan; Paul J. Zavodny

Archive | 1995

Humanisierte monoklonale antikörper gegen humanes interleukin - 4 Humanized monoclonal antibody against human interleukin - 4

Barbara Dalie; Kenneth Miller; Nicholas J. Murgolo; Stephen Tindall

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Collaboration

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Paul J. Zavodny

Schering-Plough

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Kenneth Miller

Schering-Plough

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Nicholas J. Murgolo

Merck

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Stephen Tindall

Schering-Plough

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Daniel Lundell

Schering-Plough

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Charles A. Lunn

Schering-Plough

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Hanh Nguyen

Schering-Plough

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Xuedong Fan

Schering-Plough

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Jimmy C. Tan

Schering-Plough

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John S. Abrams

Schering-Plough

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