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Advances in Applied Microbiology | 1971

Modification of Lincomycin

Barney J. Magerlein

Publisher Summary The chapter gives an account of the modification of lincomycin. The fermentation broth of streptomyces lincolnensis var. lincolnensis, a new species of streptomycete isolated from a soil sample collected in Gering, Nebraska, was found to contain a new antibiotic, named lincomycin. The announcement by Mason and coworkers of the discovery of lincomycin coincided with chemical and physical characterization of the crystalline hydrochloride. Initial reports indicated that lincomycin possessed good in vitro and in vivo potency against a variety of gram-positive microorganisms. The chapter lists lincomycin-related antibiotics, such as Celesticetin and Lincomycins. It describes the clinical modification of lincomycins and microbial modification of lincomycins and clindamycin, giving details of sulfoxide formation and phosphorylation. Chemical and microbial modifications of lincomycin have succeeded in producing derived antibiotics possessing greater potency, extended spectrum including antiparasitic activity, improved taste, and varied absorption characteristics.


Tetrahedron | 1958

The synthesis of aromatic a ring 9//10- secosteroids from unsaturated 3,11-diketo steroids

Barney J. Magerlein; John A. Hogg

Abstract The preparation of aromatic A ring 9//10 secosteroids via the pyrolysis of unsaturated 3,11-diketosteroids is described.


Journal of the American Chemical Society | 1945

The Chemical Composition of Technical DDT1

H. L. Haller; Paul D. Bartlett; Nathan L. Drake; Melvin S. Newman; Stanley J. Cristol; Charles M. Eaker; Robert A. Hayes; Glen W. Kilmer; Barney J. Magerlein; George P. Mueller; Abraham Schneider; William B. Wheatley


Journal of the American Chemical Society | 1964

Chemical Studies on Lincomycin. I. The Structure of Lincomycin

Herman Hoeksema; Brian Bannister; Robert D. Birkenmeyer; Barney J. Magerlein; F. A. MacKellar; W. Schroeder; G. Slomp; Ross R. Herr


Archive | 1958

6-fluoro steroids and process

George B Spero; Barney J. Magerlein; William P. Schneider; John A. Hogg


Journal of the American Chemical Society | 1956

ADRENAL HORMONES AND RELATED COMPOUNDS. IV. 6-METHYL STEROIDS1

George B Spero; J. L. Thompson; Barney J. Magerlein; A. R. Hanze; H. C. Murray; O. K. Sebek; John A. Hogg


Journal of the American Chemical Society | 1967

Lincomycin. V. Amino acid fragment.

Barney J. Magerlein; Robert D. Birkenmeyer; Ross R. Herr


Journal of the American Chemical Society | 1953

The Cleavage of Sulfonamides1

David I. Weisblat; Barney J. Magerlein; D. R. Myers


Archive | 1968

7-MERCAPTO-7-DEOXYLINCOMYCINS AND PROCESS FOR PREPARING THE SAME

Barney J. Magerlein


Antimicrobial Agents and Chemotherapy | 1966

Chemical modification of lincomycin

Barney J. Magerlein; Robert D. Birkenmeyer

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