Benjamin K. Potter

Heterotopic ossification following traumatic and combat-related amputations. Prevalence, risk factors, and preliminary results of excision.

BACKGROUND Although infrequently reported in amputees previously, heterotopic ossification has proven to be a common and problematic clinical entity in our recent experience in the treatment of traumatic and combat-related amputations related to Operation Enduring Freedom and Operation Iraqi Freedom. The purpose of the present study was to report the prevalence of and risk factors for heterotopic ossification following trauma-related amputation as well as the preliminary results of operative excision. METHODS We identified 330 patients with a total of 373 traumatic and combat-related amputations who had been managed at our centers between September 11, 2001 and November 30, 2005. We reviewed the medical records and radiographs of 187 patients with 213 amputations who had adequate radiographic follow-up. Additional analysis was performed for twenty-four patients with twenty-five limbs that required excision of symptomatic lesions. The mechanism and zone of injury, amputation level, timing of excision, use of prophylaxis against recurrence, and other confounding variables were examined. Outcomes were assessed by determining clinical and radiographic recurrence rates, perioperative complications, preoperative and follow-up pain medication requirements, and the ability to be fit with a functional prosthesis. RESULTS Heterotopic ossification was present in 134 (63%) of 213 residual limbs, with twenty-five lesions requiring excision. A final amputation level within the zone of injury was a risk factor for both the development and the grade of heterotopic ossification (p < 0.05). A blast mechanism was predictive of occurrence (p < 0.05) but did not correlate with grade. All patients who had been managed with excision were tolerating the prosthetic limb at an average of twelve months of follow-up. Twenty-three limbs demonstrated no evidence of recurrence, and two limbs had development of clinically asymptomatic, radiographically minimal recurrences. Six patients experienced wound-related complications that required reoperation, and two patients required subsequent minor revision surgery. There was a significant decrease in the use of pain medication following surgery (p < 0.05). CONCLUSIONS Heterotopic ossification following trauma-related amputation is more common than the literature would suggest, particularly following amputations that are performed within the initial zone of injury and those that are due to blast injuries. Many patients are asymptomatic or can be successfully managed with modification of the prosthesis. For patients with refractory symptoms, surgical excision is associated with low recurrence rates and decreased medication requirements, with acceptable complication rates.

Transforaminal lumbar interbody fusion: Clinical and radiographic results and complications in 100 consecutive patients

Objective: We retrospectively reviewed the results of 100 consecutive transforaminal lumbar interbody fusions (TLIFs) performed at one institution. The preoperative diagnoses included degenerative disk disease (55), spondylolisthesis (41; 22 isthmic, 19 degenerative), and degenerative adult scoliosis (4). There were 64 single-level, 33 two-level, 2 three-level, and 1 four-level TLIF (140 levels). Methods: The fusion mass was assessed by an independent observer using biplanar radiography, whereas clinical outcomes were assessed by means of several established outcome measures. Results: By level, the posterolateral fusion was judged to be probably or definitely solid in 78% of levels, whereas the interbody fusion was radiographically solid in 88% of levels, for an overall 93% fusion success/patient (94%/level). All patients had >24 months of postoperative clinical follow-up, and 82 patients (82%) were available for outcome measure assessment at an average follow-up of 34 months (range 24-61 months) postoperatively. Eighty-one percent of these patients reported a >50% decrease in their symptoms, and 76% of patients were satisfied with their results to the degree that they would have the procedure again. However, a large percentage of patients experienced incomplete relief of their symptoms. Twenty patients sustained minor complications, and there were no major complications. Conclusions: We conclude that TLIF is a safe and effective method of achieving lumbar fusion with a 93% radiographic fusion success and a nearly 80% rate of overall patient satisfaction but frequently results in incomplete relief of symptoms. Complications resulting from the procedure are uncommon and generally minor and transient.

Radiographic Outcomes of Anterior Spinal Fusion Versus Posterior Spinal Fusion With Thoracic Pedicle Screws for Treatment of Lenke Type I Adolescent Idiopathic Scoliosis Curves

Study Design. Analysis of radiographic outcomes following surgical correction of scoliosis. Objectives. To compare the curve correction and derotation following anterior spinal fusion (ASF) versus posterior spinal fusion (PSF) with thoracic pedicle screws. Summary of Background Data. The benefits of ASF in adolescent idiopathic scoliosis include saving distal fusion levels and historically greater correction and derotation compared with PSF. However, comparative studies between ASF and PSF have generally consisted only of posterior hook instrumentation or hybrid constructs, with no direct comparisons between anterior fusion and thoracic pedicle screw (TPS) series. Methods. We performed a retrospective review of the radiographic and medical records of 40 patients (two curve-matched groups) with Lenke Type I main thoracic adolescent idiopathic scoliosis. There were 20 patients who underwent open ASF with single-rod instrumentation with a mean age at surgery of 15 years + 6 months (range, 12–20 years) and 20 patients who underwent PSF with TPS constructs with a mean age at surgery of 13 + 6 (range, 12–15). Radiographic follow-up averaged 44.1 month (24–80) for the ASF group and 55.1 month (25–83) for the PSF/TPS group. We evaluated the sagittal alignment, Cobb angles, rib hump deformity (RH), apical rib spread difference (ARSD), and apical vertebral body-rib ratio (AVB-R), measures of rotation and thoracic torsion, between both groups. Results. Before surgery, the main thoracic curve was 55.1° (range, 47–66°) for the ASF group and 52.5° (range, 46–68°) for the PSF/TPS group (P = 0.16). Additionally, there was no difference in the pelvic tilt curves, thoracic kyphosis, lumbar lordosis, RH, or ARSD. However, there was a slightly greater preoperative thoracolumbar-lumbar (TL/L) curve (34.6° versus 29.5°, P = 0.04) and AVB-R (1.75 versus 1.5, P = 0.003) in the ASF group. After surgery, an average of 6.5 levels (range, 6–8) were fused in the ASF group, compared with 7.7 levels (range, 5–12) in the PSF/TPS group (P = 0.001) or 1.2 additional levels for PSF/TPS. At final postoperative follow-up, spontaneous pelvic tilt curve correction was greater in the ASF group (47% versus 35%), although this difference did not reach statistical significance (P = 0.07). For the main thoracic and TL/L curves, there was greater correction in the PSF/TPS group (62% versus 52%, P = 0.009; and 56% versus 41%, P = 0.03), respectively. Additionally, the PSF/TPS group demonstrated significantly greater RH correction (51% versus 26%, P = 0.005) and AVB-R ratio improvement (73% versus 32%, P < 0.0001). We also noted a trend towards increased correction of the ARSD in the PSF/TPS group (58% versus 32%, P = 0.07). Further, the postoperative thoracic kyphosis decreased 4.4° in the PSF/TPS group (postop avg. 25.0°) and increased 5.7° (average, 30.6°) in the ASF group (P = 0.04). Conclusions. In this curve-matched cohort of Lenke Type I curves, PSF with TPS provided superior instrumented correction of main thoracic curves and spontaneous correction of TL/L curves. Perhaps more importantly, PSF/TPS demonstrated improved correction of thoracic torsion and rotation as compared with ASF in terms of RH (P = 0.005) and AVB-R ratio (P= 0.0001), with only one additional spinal segment fused on average.

Bioartificial dermal substitute: a preliminary report on its use for the management of complex combat-related soft tissue wounds.

Objective: To report our institutional experience with the use of a bioartificial dermal substitute (Integra) combined with subatmospheric pressure [vacuum-assisted closure (VAC)] dressings followed by delayed split-thickness skin grafting for management of complex combat-related soft tissue wounds secondary to blast injuries. Design: Retrospective review of patients treated December 2004 through November 2005. Setting: Military treatment facility. Patients/Participants: Integra grafting was performed 18 times in 16 wounds at our institution. Indications for Integra placement were wounds not amenable to simple split-thickness skin grafting, specifically those with substantial exposed bone and/or tendon. Intervention: Patients underwent an average of 8.5 irrigation and debridement procedures and concurrent VAC dressings prior to placement of the Integra. Following Integra grafting, all patients were managed with VAC dressings, changed every 3 to 4 days at the bedside or in clinic, with subsequent split-thickness skin grafting an average of 19 days later. Main Outcome Measurements: The mechanism and date of injury, size of residual soft tissue deficit, indication for Integra placement, number of irrigation and debridement procedures prior to Integra placement, days from injury to Integra placement, days from Integra placement to split-thickness skin grafting, and clinical outcome were recorded. Results: Integra placement and subsequent skin grafting was successful in achieving durable and cosmetic definitive coverage in 15 of 16 wounds with two of these patients requiring repeat Integra application. Two patients with difficult VAC dressing placement had early Integra graft failure but successfully healed following repeated Integra application and skin grafting. Conclusions: Bioartificial dermal substitute grafting, when coupled with subatmospheric dressing management and delayed split-thickness skin grafting, is an effective technique for managing complex combat-related soft tissue wounds with exposed tendon. This can potentially lessen the need for local rotational or free flap coverage.

Surgical Revision Rates of Hooks versus Hybrid versus Screws versus Combined Anteroposterior Spinal Fusion for Adolescent Idiopathic Scoliosis

Study Design. Multi-institution retrospective review. Objective. To determine the surgical revision rates of hook, hybrid, anteroposterior, and total pedicle screw constructs for adolescent idiopathic scoliosis (AIS). Summary of Background Data. Much debate continues on the safety, efficacy, and cost of thoracic pedicle screws. Nonetheless, there are no large series that have evaluated the revision rate of various constructs in AIS to determine the need for repeat surgery, and therefore, the added indirect costs and risks of additional procedures. Methods. We retrospectively reviewed the surgical case logs of 1428 patients with AIS at 2 institutions from 1990 to 2004, and the clinical records and radiographs of revision cases. Patients were classified into 1 of 4 groups: hook, hybrid hook and screw, all pedicle screw, and combined anteroposterior fusion constructs. Overall, there were 65 (4.6%) returns to the operating room, or 55 (3.9%) cases after excluding infections without concomitant pseudarthrosis. Results. Of the 65 revision cases, there were 52 females and 13 males, at an average age at first surgery of 13.9 years (range, 9–18 years), and an average age at revision of 14.7 years (range, 12–23 years). For the revision cases, the average initial Cobb was 61.9° (range 44°–110°), and this was not statistically different within the cohorts (P > 0.05). In terms of revision rate, all hook constructs had a higher revision rate secondary to instrumentation failure when compared with screws, while both hook and hybrid constructs had an overall higher surgical revision rate when compared with screw constructs or anteroposterior constructs (all P ≤ 0.05). The pseudarthrosis rate trended toward, but did not meet, statistical significance between these same groups. Conclusion. All pedicle screw and anteroposterior constructs have a lower surgical revision rate when compared with hook and hybrid constructs. The hidden patient and financial costs of these findings should be considered when evaluating overall instrumentation efficacy.

Correlation of Short Form–36 and Disability Status With Outcomes of Arthroscopic Acetabular Labral Debridement

Background Arthroscopic debridement is the standard of care for the treatment of acetabular labral tears. The Short Form-36 has not been used to measure hip arthroscopy outcomes, and the impact of disability status on hip arthroscopy outcomes has not been reported. Hypothesis Short Form-36 subscale scores will demonstrate good correlation with the modified Harris hip score, but patients undergoing disability evaluation will have significantly worse outcome scores. Study Design Case series; Level of evidence, 4. Methods The records of active-duty soldiers who underwent hip arthroscopy at the authors’ institution were retrospectively reviewed. Forty consecutive patients who underwent hip arthroscopy for the primary indication of labral tear formed the basis of the study group. Patients completed the modified Harris hip score, the Short Form-36 general health survey, and a subjective overall satisfaction questionnaire. Results Thirty-three patients, with a mean age of 34.6 years, were available for follow-up at a mean of 25.7 months postoperatively. Fourteen (43%) patients were undergoing medical evaluation boards (military equivalent of workers’ compensation or disability claim). Pearson correlation coefficients for comparing the Short Form-36 Bodily Pain, Physical Function, and Physical Component subscale scores to the modified Harris hip score were 0.73, 0.71, and 0.85, respectively (P <. 001). The mean modified Harris hip score was significantly lower in patients on disability status than in those who were not (92.4 vs 61.1; P <. 0001). The Short Form-36 subscale scores were significantly lower in disability patients (P <. 02). Patient-reported satisfaction rates (70% overall) were 50% for those undergoing disability evaluations and 84% for those who were not (P <. 04). There was no significant difference in outcomes based on patient age, surgically proven chondromalacia, or gender for military evaluation board status. Conclusion The Short Form-36 demonstrated good correlation with the modified Harris hip score for measuring outcomes after arthroscopic partial limbectomy. Arthroscopic debridement yielded a high percentage of good results when patients undergoing disability evaluations were excluded. Disability status may be a negative predictor of success after hip arthroscopy.

Monaxial versus multiaxial thoracic pedicle screws in the correction of adolescent idiopathic scoliosis

Study Design. Radiographic outcome analysis following thoracic fusion of Lenke Type I adolescent idiopathic scoliosis (AIS) curves with segmental pedicle screw fixation. Objective. To compare the correctional capacity of monaxial versus multiaxial pedicle screws in a matched cohort of AIS patients. Summary of Background Data. Thoracic pedicle screws provide improved curve correction over hook and wire or hybrid constructs for AIS. Further, both monaxial and multiaxial screws are available, with each offering certain advantages over the other. However, different screw types have not been evaluated against each other. Methods. We retrospectively reviewed the preoperative and final postoperative follow-up radiographs of an age- and curve-matched cohort of 35 consecutive Lenke Type I AIS patients. Fifteen were treated with monaxial and 20 were treated with multiaxial pedicle screw constructs. All patients had a minimum 2-year follow-up. The average age at surgery was 14 years 4 months (range, 12–17 years) in the monaxial group and 13 years 8 months (12–16 years) in the multiaxial group. Evaluation included coronal proximal thoracic (PT), main thoracic (MT), and thoracolumbar/lumbar (TL/L) Cobb angles and flexibility indexes, regional sagittal curvature, the sagittal apical rib hump (RH) deformity, the apical vertebral body-rib ratio (AVB-R: ratio of linear measures from left and right apical body to lateral rib), and the apical rib spread distance (ARSD, difference of the sums of the intercostal distances at the five periapical segments measured at the lateral transverse process). Results. There was no statistically significant difference with regard to the preoperative PT curves, MT curves, TL/L curves, flexibility indexes, regional sagittal curvature, AVB-R, or ARSD. The preoperative rib humps were significantly greater in the monaxial screw group (42.4 mm vs. 34.7 mm; P = 0.02). Postoperative follow-up averaged 59.9 months (range, 24–98 months) for the monaxial group and 38.0 months (range, 24–55 months) for the multiaxial group (P < 0.0001). An average of 7.7 vertebral levels were fused in the monaxial group compared with 7.2 levels in the multiaxial group (P = 0.39). After surgery, both constructs provided excellent instrumented correction of the MT curves (64.9% vs. 60.0% for the monaxial and multiaxial groups, respectively; P = 0.33), as well as good spontaneous correction of the PT (41.3% vs. 40.5%; P = 0.92) and TL/L curves (55.4% vs. 51.7%; P = 0.66). Monaxial screws demonstrated significantly greater absolute (13.9 mm vs. 25.2 mm; P < 0.0001) and relative (66.1% vs. 24.7%; P < 0.0001) correction of the apical RH. Additionally, AVB-R (77.9% vs. 54.1%; P = 0.0007) and ARSD (82.8% vs. 69.9%; P = 0.04) corrections were significantly greater in the monaxial group. There were no neurologic deficits or major complications in either group. Conclusion. Both monaxial and multiaxial thoracic pedicle screws provide excellent coronal deformity correction for thoracic fusion of main thoracic AIS. Monaxial screws provide superior derotation and restoration of thoracic symmetry as noted by significantly greater correction of the AVB-R, RH, and ARSD.

Volumetric Spinal Canal Intrusion : A Comparison Between Thoracic Pedicle Screws and Thoracic Hooks

Study Design. A computer-aided design analysis. Objectives. To introduce the concept of volumetric spinal canal intrusion and report the relative intrusion volumes for thoracic pedicle screws compared to thoracic laminar and pedicle hooks. Summary of Background Data. Thoracic pedicle screws are being used more frequently; however, there is concern about neurologic risk from medial misplacement. The accepted alternative to screws is hooks. Laminar and pedicle hooks also have significant obligatory spinal canal intrusion. To date, there have been no comparison studies. Methods. Volumetric analysis of canal intrusion of pedicle screws and hooks was performed by computer-aided design CAM. All implants were of a single product line by a single manufacturer (CD Horizon M8, Medtronic Sofamor Danek). Intrusion of pedicle screws with medial positioning was analyzed in 0.5-mm increments, including a calculation of the “screw shadow,” representing additional space not available for the spinal cord between screw threads and lateral to a medially positioned screw with intrusion greater than the screw radius. The length of screw intrusion was determined from postoperative CT scans in patients with thoracic pedicle screw instrumentation. All hook styles were analyzed. The volume of the footplate in line with the dorsal surface of the footplate was considered the intruding volume for laminar hooks, with increasing offset in 0.25-mm increments to representimperfect fit. Half of the volume of the footplate was considered to be the intruding volume for pedicle hooks since a properly positioned pedicle hook straddles the pedicle. Results. Volumetric intrusion for a 4.5-mm screw ranged from 2.2 mm3 (0.5 mm medial perforation) to 83.4 mm3 (3.0 mm perforation). For a 5.5-mm screw, intrusion volume range was from 1.3 mm3 to 83.2 mm3. Accounting for the “screw shadow,” the volumetric intrusion was 9.83 mm3 to 116.3 mm3 and 10.88 mm3 to 134.89 mm3, respectively. Hook volumetric intrusion ranged from 21.15 mm3 for a pediatric narrow-blade ramped pedicle hook to 113.9 mm3 for a wide-blade laminar hook with 1.0 mm of step-off. Conclusions. A 4.5-mm or 5.5-mm thoracic pedicle screw must have a medial perforation of ≥1.5 mm to have the same volumetric spinal canal intrusion as a pediatric narrow-blade pedicle hook, the smallest hook footplate. Further, the medial violation must be >3 mm to approach the same volumetric intrusion as the largest hook. Accounting for the “screw shadow,” a thoracic pedicle screw must have a medial perforation of >2 mm to approach the same intrusion volume as a standard pedicle hook. In the absence of direct neural injury, this explains the clinical finding of medial perforation of up to 4 mm without neurologic compromise.

Comparison of manual and digital measurements in adolescent idiopathic scoliosis.

Study Design. Comparison of manual and digital measurement of radiographic parameters in patients with adolescent idiopathic scoliosis (AIS). Objective. To assess the reliability of digital measures as compared to manual measures in the evaluation of AIS. Summary of Background Data. Radiographic parameters are critical to the evaluation of patients with AIS, and are frequently used to monitor curve progression and guide treatment decisions. The reliability of many of the more common radiographic measures has only recently been elucidated for both manual and digital measures. However, a comparative analysis of manual versus digital measures has been performed only for coronal Cobb angles. The inter-technique reliability of these parameters will have increasing importance as digital radiographic viewing and analysis become commonplace. Methods. There were 2 independent, blinded observers that measured 30 complete sets of preoperative (posterior-anterior, lateral, and both side-bending) and postoperative (posterior-anterior and lateral) radiographs on 4 different occasions. For the first 2 iterations, manual measurements were taken using the same pencil and protractor. For the last 2 iterations, measurements of digitized radiographs were taken on a software measurement program (PhDx, Albuquerque, NM). Coronal measures included the main thoracic and thoracolumbar/lumbar standing and side-bending Cobb angles, apical vertebral translation, coronal balance, T1 tilt angle, lowest instrumented vertebrae angle, angulation of the disc inferior to the lowest instrumented vertebrae, apical Nash-Moe vertebral rotation, and Risser grade. Sagittal parameters included T2–T5 and T5–T12 regional thoracic kyphosis, T2–T12 thoracic kyphosis, T10–L2 thoracolumbar junction sagittal curvature, T12–S1 lumbar lordosis, and global sagittal balance. The technique-dependent measurement variability and the inter-technique (manual vs. digital), intraobserver reliability were evaluated for each radiographic parameter (within 3°). Results. Digital measurement showed decreased intraobserver variability for many (9 of 15) of the radiographic parameters assessed. Likewise, digital measures indicated good or excellent correlation with the absolute values obtained with manual measurement for many (10 of 15) parameters. All but 1 of those parameters having moderate-to-poor correlation had been previously shown to have poor reliability, regardless of measurement technique. Statistically significant differences between measurement variability were noted for 6 measures, including 2 favoring digital and 4, manual. Significant differences in the absolute values were noted for 5 measures, determined at a difference of 3°. However, the differences in both parameter variability and absolute values tended to be small and of little clinical significance for manual versus digital measurement. Conclusions. Digital measurement showed improved measurement precision and good correlation with manual measurements for the majority of AIS parameters. Absolute differences between manual and digital measurements were generally small. Therefore, digital measures are acceptable as a valid technique for scoliosis evaluation. The importance of digital versus manual measurement reliability will increase as digital radiographic viewing becomes more prevalent.

Prevention and Management of Iatrogenic Flatback Deformity

The most common cause of iatrogenic flatback syndrome is Harrington distraction instrumentation extending into the lower lumbar spine. Other common causes and exacerbating factors include failure to enhance regional lordosis during lumbar fusion for degenerative spondylosis, development of pseudarthrosis or postoperative loss of correction, development of kyphosis at the thoracolumbar junction, development of degeneration and decompensation cephalad or caudad to a prior fusion, and hip flexion contractures. Prevention of flatback syndrome involves preoperative assessment of sagittal balance, avoidance of distraction instrumentation and extension of long fusions into the lower lumbar spine, enhancement of physiologic lordosis during lumbar fusions, and intraoperative positioning with the hips extended. Treatment of flatback syndrome involves corrective pedicle subtraction or Smith-Petersen osteotomies with segmental instrumentation. Polysegmental osteotomies and vertebral column resection may be utilized in cases of sloping global sagittal imbalance and related severe coronal imbalance, respectively. Following surgical treatment, sagittal balance is generally improved with fair-to-good clinical outcomes, high patient satisfaction, and moderately high perioperative complication rates.