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Dive into the research topics where Bert Vogelstein is active.

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Featured researches published by Bert Vogelstein.


Archive | 2001

ArticleSecurin Is Required for Chromosomal Stability in Human Cells

Prasad V. Jallepalli; Irene Waizenegger; Fred Bunz; Sabine Langer; Michael R. Speicher; Jan-Michael Peters; Kenneth W. Kinzler; Bert Vogelstein; Christoph Lengauer

Abnormalities of chromosome number are the most common genetic aberrations in cancer. The mechanisms regulating the fidelity of mitotic chromosome transmission in mammalian cells are therefore of great interest. Here we show that human cells without an hSecurin gene lose chromosomes at a high frequency. This loss was linked to abnormal anaphases during which cells underwent repetitive unsuccessful attempts to segregate their chromosomes. The abnormal mitoses were associated with biochemical defects in the activation of separin, the sister-separating protease, rendering it unable to cleave the cohesin subunit Scc1 efficiently. These results illuminate the function of mammalian securin and show that it is essential for the maintenance of euploidy.


JAMA | 1989

Allelic loss in colorectal carcinoma

Scott E. Kern; Eric R. Fearon; Kasper W F Tersmette; John P. Enterline; M. Leppert; Yusuke Nakamura; Ray White; Bert Vogelstein; Stanley R. Hamilton


JAMA | 1989

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected].

Scott E. Kern; Eric R. Fearon; Tersmette Kw; Enterline Jp; M. Leppert; Yusuke Nakamura; Ray White; Bert Vogelstein; Hamilton


Archive | 1992

INHERITED AND SOMATIC MUTATIONS OF APC GENE IN COLORECTAL CANCER OF HUMANS

Kenneth W. Kinzler; Bert Vogelstein; Rakesh Anand; Philip John Hedge; Alexander Fred Markham; Hans Albertsen; Mary Carlson; Joanna Groden; Geoff Joslyn; Andrew Thliveris; Raymond L. White; Yusuke Nakamura


Archive | 2003

Secreted and cytoplasmic tumor endothelial markers

Brad St. Croix; Kenneth W. Kinzler; Bert Vogelstein


Archive | 2001

Serial analysis of transcript expression using long tags

Victor Velculescu; Andrew Sparks; Kenneth W. Kinzler; Bert Vogelstein


Archive | 1994

Tumor suppressor WAF1

Bert Vogelstein; Kenneth W. Kinzler


Archive | 2001

Jfy1 protein induces rapid apoptosis

Jian Yu; Kenneth W. Kinzler; Bert Vogelstein


Archive | 2001

Genome-based personalized medicine

Nickolas Papadopoulos; Hai Yan; Bert Vogelstein; Kenneth W. Kinzler


Archive | 2002

Non-invasive approach for assessing tumors in living animals

Bert Vogelstein; Kenneth W. Kinzler; Le-ming Shih

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Kenneth W. Kinzler

University of Wisconsin-Madison

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Frank Diehl

Johns Hopkins University

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Tong-Chuan He

Johns Hopkins University School of Medicine

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Ming Li

Johns Hopkins University

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